This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2019

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase, Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker

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Highly structured homolog pairing reflects functional organization of the Drosophila genome, Jumana AlHaj Abed, Jelena Erceg, Anton Goloborodko, Son C. Nguyen, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Bryan R. Lajoie, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

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Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses, Aniuska Becerra Artiles, John Cruz, John D. Leszyk, John Sidney, Alessandro Sette, Scott A. Shaffer, and Lawrence J. Stern

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Aquatic adaptation and depleted diversity: a deep dive into the genomes of the sea otter and giant otter, Annabel C. Beichman, Klaus-Peter Koepfli, Gang Li, William Murphy, Pasha Dobrynin, Sergei Kilver, M. Tim Tinker, Michael J. Murray, Jeremy Johnson, Kerstin Lindblad-Toh, Elinor K. Karlsson, Kirk E. Lohmueller, and Robert K. Wayne

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Mechanistic Basis for Control of Early Embryonic Development by a 5’ tRNA Fragment, Xin Y. Bing

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis, Laura Cau, Hidenari Takahara, Paul R. Thompson, Guy Serre, Marie-Claire Mechin, and Michel Simon

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The Plasticity and Variation in Gene Expression during Development in C. elegans, Io Long Chan

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Exploring the Complex Folding Free Energy Landscapes of a Series of β-rich Proteins, Noah R. Cohen

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Nonnative structure in a peptide model of the unfolded state of SOD1: Implications for ALS-linked aggregation, Noah R. Cohen, Jill A. Zitzewitz, Osman Bilsel, and C. Robert Matthews

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MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

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Control of cellular responses to mechanical cues through YAP/TAZ regulation, Ishani Dasgupta and Dannel McCollum

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Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study, Kristina M. Deligiannidis, Christina L. Fales, Aimee Kroll-Desrosiers, Scott A. Shaffer, Vanessa Villamarin, Yanglan Tan, Janet E. Hall, Blaise B. Frederick, Elif M. Sikoglu, Richard A. Edden, Anthony J. Rothschild, and Constance M. Moore

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Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment, Vishnu Dileep, Rachel Patton McCord, Job Dekker, and David M. Gilbert

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos, Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

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Heterochromatin drives compartmentalization of inverted and conventional nuclei, Martin Falk, Yana Feodorova, Natalia Naumova, Maxim Imakaev, Bryan R. Lajoie, Heinrich Leonhardt, Boris Joffe, Job Dekker, Geoffrey Fudenberg, Irina Solovei, and Leonid A. Mirny (Nature, 2019-06-05)

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Multimodal quantitative imaging of brain cancer in cultured cells, Xin Feng, Alona Muzikansky, Alonzo H. Ross, Michael R. Hamblin, Peter R. Jermain, and Anna N. Yaroslavsky

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Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization, Elizabeth H. Finn, Gianluca Pegoraro, Hugo B. Brandao, Anne-Laure Valton, Marlies E. Oomen, Job Dekker, Leonid Mirny, and Tom Misteli (Cell, 2019-03-07)

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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer, A. J. Fritz, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Gary S. Stein

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The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome, Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, and Neil Brockdorff

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The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria, Daniel Tianfang Ge, Wei Wang, Cindy Tipping, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore

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Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons, Fedor E. Gusev, Anastasia P. Grigorenko, Elena Filippova, Zhiping Weng, Schahram Akbarian, and Evgeny I. Rogaev

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Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects, Omar Hamdani, Tsung-Han S. Hsieh, Oliver J. Rando, and Rohinton T. Kamakaka

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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The Mechanism and Regulation of Bacteriophage DNA Packaging Motors, Janelle A. Hayes

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Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance, Mina Henes, Klajdi Kosovrasti, Gordon J. Lockbaum, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer, and Troy W. Whitfield

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Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance, Mina Henes, Gordon J. Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Sook-Kyung Lee, Ean Spielvogel, Shuntai Zhou, Ronald Swanstrom, Daniel N. Bolon, Nese Kurt Yilmaz, and Celia A. Schiffer

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RUNX1-dependent mechanisms in biological control and dysregulation in cancer, Deli Hong, Andrew J. Fritz, Jonathan A. Gordon, Coralee E. Tye, Joseph R. Boyd, Kirsten M. Tracy, Seth E. Frietze, Frances E. Carr, Jeffrey A. Nickerson, Andre J. Van Wijnen, Anthony N. Imbalzano, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations, Rieko Ishima, Nese Kurt Yilmaz, and Celia A. Schiffer

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness, Utsav Joshi, Lawrence J. Stern, and Laila Abdullah

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Leptin induces cell migration and invasion in a FAK-Src- dependent manner in breast cancer cells, Juan Carlos Juarez-Cruz, Miriam Daniela. Zuniga-Eulogio, Monserrat Olea-Flores, Eduardo Castaneda-Saucedo, Miguel Angel. Mendoza-Catalan, Carlos Ortuno-Pineda, Ma Elena. Moreno-Godinez, Socrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing, Elsenoor Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph Contessa, and Richard Steet

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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Ste5 Membrane Localization Allows MAPK Pathway Signaling in trans Between Kinases on Separate Scaffold Molecules, Rachel E. Lamson, Matthew J. Winters, and Peter M. Pryciak

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Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints, Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer

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Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells, Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, and Xuesen Zhang

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Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley

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Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages, Neha Mishra, Lidja Schwerdtner, Kelly Sams, Santanu Mondal, Fareed Ahmad, Reinhold E. Schmidt, Scott A. Coonrod, Paul R. Thompson, Markus M. Lerch, and Lukas Bossaller

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Halogen Bonding Increases the Potency and Isozyme-selectivity of Protein Arginine Deiminase 1 Inhibitors, Santanu Mondal, Xuefeng Gong, Xiaoqian Zhang, Ari J. Salinger, Li Zheng, Sudeshna Sen, Eranthie Weerapana, Xuesen Zhang, and Paul R. Thompson

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Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination, Santanu Mondal and Paul R. Thompson

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BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer, Rohini Muthuswami, LeeAnn Bailey, Radhakrishnan Rakesh, Anthony N. Imbalzano, Jeffrey A. Nickerson, and Joel W. Hockensmith

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Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination, Mitesh Nagar, Ronak Tilvawala, and Paul R. Thompson

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Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer, Monserrat Olea-Flores, Miriam Daniela Zuniga-Eulogio, Miguel Angel Mendoza-Catalan, Hugo Alberto Rodriguez-Ruiz, Eduardo Castaneda-Saucedo, Carlos Ortuno-Pineda, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells, Monserrat Olea-Flores, Miriam Zuniga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sanchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalan, Eduardo Perez Salazar, Alejandra Garcia-Hernandez, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Leptin promotes expression of EMT-related transcription factors and invasion in a Src and FAK-dependent pathway in MCF10A mammary epithelial cells, Monserrat Olea-Flores, Miriam Zuñiga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sánchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalán, Eduardo Pérez Salazar, Alejandra García-Hernández, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

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CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning, Marlies E. Oomen, Anders S. Hansen, Yu Liu, Xavier Darzacq, and Job Dekker (Genome research, 2019-02-01)

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Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors, Aysegul Ozen, Kristina L. Prachanronarong, Ashley N. Matthew, Djade I. Soumana, and Celia A. Schiffer

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Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex, Lovely Jael Paul Solomon Devakumar, Christl Gaubitz, Victoria Lundblad, Brian A. Kelch, and Takashi Kubota

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions, Ivan Peran, Alex S. Holehouse, Isaac S. Carrico, Rohit V. Pappu, Osman Bilsel, and Daniel P. Raleigh

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Spatial genome exploration in the context of cognitive and neurological disease, Prashanth Rajarajan, Tyler M. Borrman, Will Liao, Sergio Espeso-Gil, Sandhya Chandrasekaran, Yan Jiang, Zhiping Weng, Kristen J. Brennand, and Schahram Akbarian

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Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function, Pablo Reyes-Gutierrez, Jake W. Carrasquillo-Rodriguez, and Anthony N. Imbalzano

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Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination, Vera D. Rinaldi, Jordana C. Bloom, and John C. Schimenti

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HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope, Linah N. Rusere, Gordon J. Lockbaum, Sook-Kyung Lee, Mina Henes, Klajdi Kosovrasti, Ean Spielvogel, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, and Akbar Ali

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HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet beta-Cells From Donors With Type 1 Diabetes, Mark A. Russell, Sambra D. Redick, David Blodgett, Jenny Aurielle B. Babon, Chaoxing Yang, Sally C. Kent, Alan G. Derr, Alper Kucukural, Manuel Garber, and David M. Harlan

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Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase, Sudeshna Sen, Santanu Mondal, Li Zheng, Ari J. Salinger, Walter Fast, Eranthie Weerapana, and Paul R. Thompson

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APOBEC3s: DNA-editing human cytidine deaminases, Tania V. Silvas and Celia A. Schiffer

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Structural and Biochemical Studies of Membrane Proteins CFTR and GLUT1 Yield New Insights into the Molecular Basis of Cystic Fibrosis and Biology of Glucose Transport, Kailene S. Simon

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Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange, Raushan K. Singh, Jiayi Fan, Nathan Gioacchini, Shinya Watanabe, Osman Bilsel, and Craig L. Peterson

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Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, and Hiroshi Matsuo

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Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury, Nicoletta Sorvillo, Daniella M. Mizurini, Carmen Coxon, Kimberly Martinod, Ronak Tilvawala, Deya Cherpokova, Ari J. Salinger, Robert J. Seward, Caleb Staudinger, Eranthie Weerapana, Nathan I. Shapiro, Catherine E. Costello, Paul R. Thompson, and Denisa D. Wagner

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The TALE Factors and Nuclear Factor Y Cooperate to Drive Transcription at Zygotic Genome Activation, William J. Stanney III

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TALE and NF-Y co-occupancy marks enhancers of developmental control genes during zygotic genome activation in zebrafish, William J. Stanney III, Franck Ladam, Ian J. Donaldson, Teagan J. Parsons, Rene Maehr, Nicoletta Bobola, and Charles G. Sagerstrom

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Elucidating the structural mechanisms of capsid stability and assembly using a hyperthermophilic bacteriophage, Nicholas P. Stone

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Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure, Nicholas P. Stone, Gabriel Demo, Emily Agnello, and Brian A. Kelch

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Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure, Nicholas P. Stone, Gabriel Demo, Emily Agnello, and Brian A. Kelch

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Extensive ribosome and RF2 rearrangements during translation termination, Egor Svidritskiy, Gabriel Demo, Anna B. Loveland, Chen Xu, and Andrei A. Korostelev

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MTF1, a classic metal sensing transcription factor, promotes myogenesis in response to copper, Cristina Tavera-Montañez, Sarah J. Hainer, Daniella Cangussu, Shellaina J. V. Gordon, Yao Xiao, Pablo Reyes-Gutierrez, Anthony N. Imbalzano, Juan G. Navea, Thomas G. Fazzio, and Teresita Padilla-Benavides

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Peptidyl arginine deiminases: detection and functional analysis of protein citrullination, Ronak Tilvawala and Paul R. Thompson

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Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir, Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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Integrating ab initio and template-based algorithms for protein-protein complex structure prediction, Sweta Vangaveti, Thom Vreven, Yang Zhang, and Zhiping Weng

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Ouabain Enhances Cell-Cell Adhesion Mediated by beta1 Subunits of the Na(+),K(+)-ATPase in CHO Fibroblasts, Claudia Andrea Vilchis-Nestor, Maria Luisa Roldan, Angelina Leonardi, Juan G. Navea, Teresita Padilla-Benavides, and Liora Shoshani

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Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation, Aaron D. Viny, Yu Liu, Job Dekker, and Ross L. Levine (Cell stem cell, 2019-08-30)

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Computational investigation into the fluorescence of luciferin analogues, Thom Vreven and Stephen C. Miller

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Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme, Hanna Witwicka, Jumpei Nogami, Sabriya A. Syed, Kazumitsu Maehara, Teresita Padilla-Benavides, Yasuyuki Ohkawa, and Anthony N. Imbalzano

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Measuring the reproducibility and quality of Hi-C data, Galip Gurkan Yardimci, Hakan Ozadam, Bryan R. Lajoie, Ye Zhan, Job Dekker, and William S. Noble

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Understanding the Role of Prdm12b in Zebrafish Development, Ozge Yildiz

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Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain, Ozge Yildiz, Gerald B. Downes, and Charles G. Sagerstrom

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Genome-wide analysis of polymerase III-transcribed Alu elements suggests cell-type-specific enhancer function, Xiao-Ou Zhang, Thomas R. Gingeras, and Zhiping Weng

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Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2, Li Zheng, Mitesh Nagar, Aaron J. Maurais, Daniel J. Slade, Sangram S. Parelkar, Scott A. Coonrod, Eranthie Weerapana, and Paul R. Thompson

Publications from 2018

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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NmeCas9 is an intrinsically high-fidelity genome-editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes, Robert J. Asaro, Qiang Zhu, Pedro Cabrales, and Anthony Carruthers

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Evaluation of a method to measure HHV-6B infection in vitro based on cell size, Aniuska Becerra, Tessa Santoro, and Lawrence J. Stern

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Assembly of human C-terminal binding protein (CtBP) into tetramers, Andrew G. Bellesis, Anne M. Jecrois, Janelle A. Hayes, Celia A. Schiffer, and William E. Royer

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Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing, Mehmet F. Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, and Scot A. Wolfe

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Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways, Daniel L. Bourque, Diane P. Genereux, Elinor K. Karlsson, Firdausi Qadri, and Jason B. Harris

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Ajulemic acid: potential treatment for chronic inflammation, Sumner Burstein

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Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness, Aneth S. Canale, Sergey V. Venev, Troy W. Whitfield, Daniel R. Caffrey, Wayne A. Marasco, Celia A. Schiffer, Timothy F. Kowalik, Jeffrey D. Jensen, Robert W. Finberg, Konstantin B. Zeldovich, Jennifer P. Wang, and Daniel N. Bolon

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Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster, Timothy Chang, Eugenio Mattei, Ildar Gainetdinov, Cansu Colpan, Zhiping Weng, and Phillip D. Zamore

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Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization, Io Long Chan, Oliver J. Rando, and Colin C. Conine

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Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling, Weijun Chen, Jill E. Moore, Hakan Ozadam, Hennady P. Shulha, Nicholas Rhind, Zhiping Weng, and Melissa J. Moore

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Illuminating Biology with Membrane Penetrating Sulfonate Delivery Scaffolds and Near-Infrared Azasiline Fluorophores, Adam Choi

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Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

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Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

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Immunocontraceptive target repertoire defined by systematic identification of sperm membrane alloantigens in a single species, Nathaly Cormier, John J. McGlone, John D. Leszyk, and Daniel M. Hardy

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The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans, Gregory M. Davis, Shikui Tu, Jacqueline A. Wilce, Julie M. Claycomb, Zhiping Weng, and Peter R. Boag