This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2020

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Deconstructing bioluminescence: from molecular detail to in vivo imaging., Spencer T. Adams Jr.

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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding, Chen Bao, Sarah Loerch, Clarence Ling, Andrei A. Korostelev, Nikolaus Grigorieff, and Dmitri N. Ermolenko

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Understanding the Production and Stability of Mouse PIWI-Interacting RNAs, Cansu Colpan

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Flexibility and constraint in preimplantation gene regulation in mouse, Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts, Stephen S. Gisselbrecht, Alexandre Palagi, Jesse V. Kurland, Julia M. Rogers, Hakan Ozadam, Ye Zhan, Job Dekker, and Martha L. Bulyk (Molecular cell, 2020-01-16)

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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry, Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

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STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells, Magdalena M. Kordon, Miroslaw Zarebski, Kamil Solarczyk, Hanhui Ma, Thoru Pederson, and Jurek W. Dobrucki

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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways, Carrie A. Kovalak

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Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures, Gordon J. Lockbaum, Florian Leidner, William E. Royer, Nese Kurt Yilmaz, and Celia A. Schiffer

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Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1, Heather S. Loring, Janneke D. Icso, Venkatesh V. Nemmara, and Paul R. Thompson

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Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases, Heather S. Loring and Paul R. Thompson

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Detecting chromatin interactions along and between sister chromatids with SisterC, Marlies E. Oomen, Adam K. Hedger, Jonathan K. Watts, and Job Dekker

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Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans, Deniz M. Ozata, Tianxiong Yu, Haiwei Mou, Ildar Gainetdinov, Cansu Colpan, Katharine Cecchini, Yasin Kaymaz, Pei-Hsuan Wu, Kaili Fan, Alper Kucukural, Zhiping Weng, and Phillip D. Zamore

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CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis, Teresita Padilla-Benavides, Dominic T. Haokip, Yeonsoo Yoon, Pablo Reyes-Gutierrez, Jaime A. Rivera, and Anthony N. Imbalzano

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An atlas of cell types in the mammalian epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors, Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, and Xin Zhiguo Li

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Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir, Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines, Pinar Uysal-Onganer, Amy MacLatchy, Rayan Mahmoud, Igor Kraev, Paul R. Thompson, Jameel M. Inal, and Sigrun Lange

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Performance of ZDOCK and IRAD in CAPRI rounds 39-45, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Jennifer C. Gaines, and Zhiping Weng

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HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

Publications from 2019

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase, Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker

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A chromosome folding intermediate at the condensin-to-cohesin transition during telophase, Kristin Abramo, Anne-Laure Valton, Sergey V. Venev, Hakan Ozadam, A. Nicole Fox, and Job Dekker (Nature cell biology, 2019-11-01)

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Highly structured homolog pairing reflects functional organization of the Drosophila genome, Jumana AlHaj Abed, Jelena Erceg, Anton Goloborodko, Son C. Nguyen, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Bryan R. Lajoie, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

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Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses, Aniuska Becerra Artiles, John Cruz, John D. Leszyk, John Sidney, Alessandro Sette, Scott A. Shaffer, and Lawrence J. Stern

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Aquatic adaptation and depleted diversity: a deep dive into the genomes of the sea otter and giant otter, Annabel C. Beichman, Klaus-Peter Koepfli, Gang Li, William Murphy, Pasha Dobrynin, Sergei Kilver, M. Tim Tinker, Michael J. Murray, Jeremy Johnson, Kerstin Lindblad-Toh, Elinor K. Karlsson, Kirk E. Lohmueller, and Robert K. Wayne

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Mechanistic Basis for Control of Early Embryonic Development by a 5’ tRNA Fragment, Xin Y. Bing

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Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon

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HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation, Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Charles G. Sagerstrom, Kimberley A. Mace, Magnus Rattray, and Nicoletta Bobola

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Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals, Nicholas R. Casewell, Elinor K. Karlsson, Daniel Petras, Daren C. Card, Vivek Suranse, Alexis M. Mychajliw, David Richards, Ivan Koludarov, Laura-Oana Albulescu, Julien Slagboom, Benjamin-Florian Hempel, Neville M. Ngum, Rosalind J. Kennerley, Jorge L. Brocca, and Gareth Whiteley

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Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis, Laura Cau, Hidenari Takahara, Paul R. Thompson, Guy Serre, Marie-Claire Mechin, and Michel Simon

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The Plasticity and Variation in Gene Expression during Development in C. elegans, Io Long Chan

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Exploring the Complex Folding Free Energy Landscapes of a Series of β-rich Proteins, Noah R. Cohen

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Nonnative structure in a peptide model of the unfolded state of SOD1: Implications for ALS-linked aggregation, Noah R. Cohen, Jill A. Zitzewitz, Osman Bilsel, and C. Robert Matthews

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MicroRNAs Absent in Caput Sperm Are Required for Normal Embryonic Development, Colin C. Conine, Fengyun Sun, Lina Song, Jaime A. Rivera-Perez, and Oliver J. Rando

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The adaptive potential of the M-domain of yeast Hsp90, Pamela A. Cote-Hammarlof, Inês Fragata, Julia M. Flynn, Konstantin B. Zeldovich, Claudia Bank, and Daniel N. Bolon

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Control of cellular responses to mechanical cues through YAP/TAZ regulation, Ishani Dasgupta and Dannel McCollum

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes, Sanchaita Das, Andrew W. Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C. Irving, Osman Bilsel, Jacqueline Cherfils, and David G. Lambright

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Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study, Kristina M. Deligiannidis, Christina L. Fales, Aimee Kroll-Desrosiers, Scott A. Shaffer, Vanessa Villamarin, Yanglan Tan, Janet E. Hall, Blaise B. Frederick, Elif M. Sikoglu, Richard A. Edden, Anthony J. Rothschild, and Constance M. Moore

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Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy, Alec M. DeSimone; John D. Leszyk; Kathryn Wagner; and Charles P. Emerson, Jr.

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Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment, Vishnu Dileep, Rachel Patton McCord, Job Dekker, and David M. Gilbert

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TRAPPing a Rab GTPase by the Tail, Jianjun Duan and David G. Lambright

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Modulating MCM Levels Causes Differential Loading at Origins of Replication and Changes Replication Timing, Livio Dukaj

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The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos, Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, and C-Ting Wu (Nature communications, 2019-10-03)

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Heterochromatin drives compartmentalization of inverted and conventional nuclei, Martin Falk, Yana Feodorova, Natalia Naumova, Maxim Imakaev, Bryan R. Lajoie, Heinrich Leonhardt, Boris Joffe, Job Dekker, Geoffrey Fudenberg, Irina Solovei, and Leonid A. Mirny (Nature, 2019-06-05)

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Multimodal quantitative imaging of brain cancer in cultured cells, Xin Feng, Alona Muzikansky, Alonzo H. Ross, Michael R. Hamblin, Peter R. Jermain, and Anna N. Yaroslavsky

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Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization, Elizabeth H. Finn, Gianluca Pegoraro, Hugo B. Brandao, Anne-Laure Valton, Marlies E. Oomen, Job Dekker, Leonid Mirny, and Tom Misteli (Cell, 2019-03-07)

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Investigating the influence of environment on the evolution of Hsp90 using comprehensive fitness maps, Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Ines Fragata, David Mavor, Carl Hollins III, Claudia Bank, and Daniel N. Bolon

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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer, A. J. Fritz, Jeffrey A. Nickerson, Anthony N. Imbalzano, and Gary S. Stein

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The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome, Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, and Neil Brockdorff

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The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria, Daniel Tianfang Ge, Wei Wang, Cindy Tipping, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore

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Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons, Fedor E. Gusev, Anastasia P. Grigorenko, Elena Filippova, Zhiping Weng, Schahram Akbarian, and Evgeny I. Rogaev

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Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects, Omar Hamdani, Tsung-Han S. Hsieh, Oliver J. Rando, and Rohinton T. Kamakaka

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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The Mechanism and Regulation of Bacteriophage DNA Packaging Motors, Janelle A. Hayes

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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry, Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

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Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance, Mina Henes, Klajdi Kosovrasti, Gordon J. Lockbaum, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer, and Troy W. Whitfield

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Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance, Mina Henes, Gordon J. Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Sook-Kyung Lee, Ean Spielvogel, Shuntai Zhou, Ronald Swanstrom, Daniel N. Bolon, Nese Kurt Yilmaz, and Celia A. Schiffer

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RUNX1-dependent mechanisms in biological control and dysregulation in cancer, Deli Hong, Andrew J. Fritz, Jonathan A. Gordon, Coralee E. Tye, Joseph R. Boyd, Kirsten M. Tracy, Seth E. Frietze, Frances E. Carr, Jeffrey A. Nickerson, Andre J. Van Wijnen, Anthony N. Imbalzano, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations, Rieko Ishima, Nese Kurt Yilmaz, and Celia A. Schiffer

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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A DNA-guided Argonaute Protein Functions in DNA Replication in Thermus thermophilus, Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, and Phillip D. Zamore

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A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness, Utsav Joshi, Lawrence J. Stern, and Laila Abdullah

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Leptin induces cell migration and invasion in a FAK-Src- dependent manner in breast cancer cells, Juan Carlos Juarez-Cruz, Miriam Daniela. Zuniga-Eulogio, Monserrat Olea-Flores, Eduardo Castaneda-Saucedo, Miguel Angel. Mendoza-Catalan, Carlos Ortuno-Pineda, Ma Elena. Moreno-Godinez, Socrates Villegas-Comonfort, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia, Daria A. Khrabrova, Andrei G. Loiko, Anastasia A. Tolkacheva, Natalia A. Cherepanova, Maria I. Zvereva, Olga V. Kirsanova, and Elizaveta S. Gromova

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Cyclophilin A protects HIV-1 from restriction by human TRIM5alpha, Kyusik Kim, Ann Dauphin, Sevnur Komurlu, Sean M. McCauley, Leonid Yurkovetskiy, Claudia Carbone, William E. Diehl, Caterina Strambio-De-Castilla, Edward M. Campbell, and Jeremy Luban

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Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing, Elsenoor Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph Contessa, and Richard Steet

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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways, Carrie Kovalak, Mihir Metkar, and Melissa J. Moore

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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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Ste5 Membrane Localization Allows MAPK Pathway Signaling in trans Between Kinases on Separate Scaffold Molecules, Rachel E. Lamson, Matthew J. Winters, and Peter M. Pryciak

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Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints, Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer

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Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment, Marc F. Lensink, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Zhiping Weng, and Shoshana J. Wodak

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Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells, Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, and Xuesen Zhang

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley

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Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae, Yuqian Ma, Jin Bao, Yuanwei Zhang, Zhan Jun Li, Xiangyu Zhou, Changlin Wan, Ling Huang, Yang Zhao, Gang Han, and Tian Xue

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Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma, Kate Megquier, Elinor K. Karlsson, and Kerstin Lindblad-Toh

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Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages, Neha Mishra, Lidja Schwerdtner, Kelly Sams, Santanu Mondal, Fareed Ahmad, Reinhold E. Schmidt, Scott A. Coonrod, Paul R. Thompson, Markus M. Lerch, and Lukas Bossaller

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Halogen Bonding Increases the Potency and Isozyme-selectivity of Protein Arginine Deiminase 1 Inhibitors, Santanu Mondal, Xuefeng Gong, Xiaoqian Zhang, Ari J. Salinger, Li Zheng, Sudeshna Sen, Eranthie Weerapana, Xuesen Zhang, and Paul R. Thompson

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Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination, Santanu Mondal and Paul R. Thompson

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BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer, Rohini Muthuswami, LeeAnn Bailey, Radhakrishnan Rakesh, Anthony N. Imbalzano, Jeffrey A. Nickerson, and Joel W. Hockensmith

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Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination, Mitesh Nagar, Ronak Tilvawala, and Paul R. Thompson

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Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer, Monserrat Olea-Flores, Miriam Daniela Zuniga-Eulogio, Miguel Angel Mendoza-Catalan, Hugo Alberto Rodriguez-Ruiz, Eduardo Castaneda-Saucedo, Carlos Ortuno-Pineda, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells, Monserrat Olea-Flores, Miriam Zuniga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sanchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalan, Eduardo Perez Salazar, Alejandra Garcia-Hernandez, Teresita Padilla-Benavides, and Napoleon Navarro-Tito

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Leptin promotes expression of EMT-related transcription factors and invasion in a Src and FAK-dependent pathway in MCF10A mammary epithelial cells, Monserrat Olea-Flores, Miriam Zuñiga-Eulogio, Arvey Tacuba-Saavedra, Magdalena Bueno-Salgado, Andrea Sánchez-Carvajal, Yovani Vargas-Santiago, Miguel A. Mendoza-Catalán, Eduardo Pérez Salazar, Alejandra García-Hernández, Teresita Padilla-Benavides, and Napoleón Navarro-Tito

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CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning, Marlies E. Oomen, Anders S. Hansen, Yu Liu, Xavier Darzacq, and Job Dekker (Genome research, 2019-02-01)

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Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex, Lovely Jael Paul Solomon Devakumar, Christl Gaubitz, Victoria Lundblad, Brian A. Kelch, and Takashi Kubota

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Enhanced Cas12a editing in mammalian cells and zebrafish, Pengpeng Liu, Kevin Luk, Masahiro Shin, Feston Idrizi, Samantha F. Kwok, Benjamin P. Roscoe, Esther Mintzer, Sneha Suresh, Kyle Morrison, Josias B. Frazao, Mehmet Fatih Bolukbasi, Karthikeyan Ponnienselvan, Jeremy Luban, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions, Ivan Peran, Alex S. Holehouse, Isaac S. Carrico, Rohit V. Pappu, Osman Bilsel, and Daniel P. Raleigh

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Spatial genome exploration in the context of cognitive and neurological disease, Prashanth Rajarajan, Tyler M. Borrman, Will Liao, Sergio Espeso-Gil, Sandhya Chandrasekaran, Yan Jiang, Zhiping Weng, Kristen J. Brennand, and Schahram Akbarian

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Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function, Pablo Reyes-Gutierrez, Jake W. Carrasquillo-Rodriguez, and Anthony N. Imbalzano

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Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination, Vera D. Rinaldi, Jordana C. Bloom, and John C. Schimenti

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HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope, Linah N. Rusere, Gordon J. Lockbaum, Sook-Kyung Lee, Mina Henes, Klajdi Kosovrasti, Ean Spielvogel, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, and Akbar Ali

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HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet beta-Cells From Donors With Type 1 Diabetes, Mark A. Russell, Sambra D. Redick, David Blodgett, Jenny Aurielle B. Babon, Chaoxing Yang, Sally C. Kent, Alan G. Derr, Alper Kucukural, Manuel Garber, and David M. Harlan

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Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase, Sudeshna Sen, Santanu Mondal, Li Zheng, Ari J. Salinger, Walter Fast, Eranthie Weerapana, and Paul R. Thompson

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APOBEC3s: DNA-editing human cytidine deaminases, Tania V. Silvas and Celia A. Schiffer

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Structural and Biochemical Studies of Membrane Proteins CFTR and GLUT1 Yield New Insights into the Molecular Basis of Cystic Fibrosis and Biology of Glucose Transport, Kailene S. Simon

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Transient Kinetic Analysis of SWR1C-Catalyzed H2A.Z Deposition Unravels the Impact of Nucleosome Dynamics and the Asymmetry of Histone Exchange, Raushan K. Singh, Jiayi Fan, Nathan Gioacchini, Shinya Watanabe, Osman Bilsel, and Craig L. Peterson

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Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA, William C. Solomon, Wazo Myint, Shurong Hou, Tapan Kanai, Rashmi Tripathi, Nese Kurt Yilmaz, Celia A. Schiffer, and Hiroshi Matsuo