This collection showcases the books, journal articles, book reviews, and other publications and presentations written by faculty and researchers of the Department of Biochemistry and Molecular Pharmacology.

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Publications from 2021

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The Adaptive Potential of the Middle Domain of Yeast Hsp90, Pamela A. Cote-Hammarlof, Ines Fragata, Julia M. Flynn, David Mavor, Konstantin B. Zeldovich, Claudia Bank, and Daniel N. Bolon

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Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses, Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, and Wayne A Marasco

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Long wavelength single photon like driven photolysis via triplet triplet annihilation, Ling Huang, Le Zeng, Yongzhi Chen, Nuo Yu, Lei Wang, Kai Huang, Yang Zhao, and Gang Han

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Inhibiting HTLV-1 Protease: A Viable Antiviral Target, Gordon J. Lockbaum, Mina Henes, Nathaniel Talledge, Linah Rusere, Klajdi Kosovrasti, Ellen A. Nalivaika, Mohan Somasundaran, Akbar Ali, Louis M. Mansky, Nese Kurt Yilmaz, and Celia A. Schiffer

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Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188, Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, and Celia A. Schiffer

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Insights into the Role of SARM1 in Pathological Neuron Death, Heather S. Loring

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines, Jeremy Luban, Caterina Strambio-De-Castilla, Yetao Wang, Allan Jacobson, and Stuart W. Peltz

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Interactions of APOBEC3s with DNA and RNA, Atanu Maiti, Shurong Hou, Celia A. Schiffer, and Hiroshi Matsuo

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Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond, Ashley N. Matthew, Florian Leidner, Gordon J. Lockbaum, Mina Henes, Jacqueto Zephyr, Shurong Hou, Nageswara Rao Desaboini, Jennifer Timm, Linah N. Rusere, Debra A. Ragland, Janet L. Paulsen, Kristina L. Prachanronarong, Djade I. Soumana, Ellen A. Nalivaika, Nese Kurt Yilmaz, Akbar Ali, and Celia A. Schiffer

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Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System [preprint], Michael P. Moazami, Julia M. Rembetsy-Brown, Feng Wang, Pranathi Meda Krishnamurthy, Alexandra Weiss, Miklos G. Marosfoi, Robert M. King, Mona Motwani, Heather L. Gray-Edwards, Katherine A. Fitzgerald, Robert H. Brown Jr., and Jonathan K. Watts

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Site-specific incorporation of citrulline into proteins in mammalian cells, Santanu Mondal, Shu Wang, Yunan Zheng, Sudeshna Sen, Abhishek Chatterjee, and Paul R. Thompson

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Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies [preprint], Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, and Paul Bieniasz

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NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP), Jeffry C. Nichols, Celia A. Schiffer, and William E. Royer

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Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection [preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, and Jeremy Luban

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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML, Zuzana Tothova, Anne-Laure Valton, Sergey V. Venev, Job Dekker, and Benjamin L. Ebert

Publications from 2020

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Deconstructing bioluminescence: from molecular detail to in vivo imaging., Spencer T. Adams Jr.

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Systematic evaluation of chromosome conformation capture assays [preprint], Betul Akgol-Oksuz, Liyan Yang, Sergey V. Venev, Nils Krietenstein, Krishna M. Parsi, Hakan Ozadam, Marlies E. Oomen, Ankita Nand, Hui Mao, Ryan M.J. Genga, Rene Maehr, Oliver J. Rando, Johan H. Gibcus, and Job Dekker

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In-Vitro Sorbent-Mediated Removal of Edoxaban from Human Plasma and Albumin Solution, Alexandra A. Angheloiu, Yanglan Tan, Cristian Ruse, Scott A. Shaffer, and George O. Angheloiu

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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding, Chen Bao, Sarah Loerch, Clarence Ling, Andrei A. Korostelev, Nikolaus Grigorieff, and Dmitri N. Ermolenko

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mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding [preprint], Chen Bao, Sarah Loerch, Clarence Ling, Andrei A. Korostelev, Nikolaus Grigorieff, and Dmitri N. Ermolenko

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Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress, L M. Bogomolnaya, Ronak Tilvawala, J. R. Elfenbein, J. D. Cirillo, and H. L. Andrews-Polymenis

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HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation, Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Syed Murtuza Baker, Charles G. Sagerstrom, Kimberly A. Mace, Magnus Rattray, and Nicoletta Bobola

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Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain, Caroline Brossas, Anne-Laure Valton, Sergey V. Venev, Sabarinadh Chilaka, Antonin Counillon, Marc Laurent, Coralie Goncalves, Benedicte Duriez, Franck Picard, Job Dekker, and Marie-Noelle Prioleau

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Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP, Uriel Bulow, Ramesh Govindan, and James B. Munro

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Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes, Erica P. Cai, Yuki Ishikawa, Wei Zhang, Nayara C. Leite, Jian Li, Shurong Hou, Badr Kiaf, Jennifer Hollister-Lock, Nese Kurt Yilmaz, Celia A. Schiffer, Douglas A. Melton, Stephan Kissler, and Peng Yi

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ArfB can displace mRNA to rescue stalled ribosomes, Christine E. Carbone, Gabriel Demo, Rohini Madireddy, Egor Svidritskiy, and Andrei A. Korostelev

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Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome compaction and individualization [preprint], Pavan Choppakatla, Bastiaan Dekker, Erin E. Cutts, Alessandro Vannini, Job Dekker, and Hironori Funabiki

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Understanding the Production and Stability of Mouse PIWI-Interacting RNAs, Cansu Colpan

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Flexibility and constraint in preimplantation gene regulation in mouse [preprint], Colin C. Conine, Marina Krykbaeva, Lina Song, Robert C. Brewster, Nir Friedman, and Oliver J. Rando

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Investigating Evolutionary Innovation in Yeast Heat Shock Protein 90, Pamela Cote-Hammarlof

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Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding, Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, and James B. Munro

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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation [preprint], Gabriel Demo, Anna B. Loveland, Egor Svidritskiy, Howard B. Gamper, Ya-Ming Hou, and Andrei A. Korostelev

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SPEN integrates transcriptional and epigenetic control of X-inactivation, Francois Dossin, Ines Pinheiro, Jan J. Zylicz, Julia Roensch, Samuel Collombet, Agnes Le Saux, Tomasz Chelmicki, Mikael Attia, Varun Kapoor, Ye Zhan, Florent Dingli, Damarys Loew, Thomas Mercher, Job Dekker, and Edith Heard (Nature, 2020-02-05)

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Competition for MCM Loading at Origins Establishes Replication Timing Patterns [preprint], Livio Dukaj and Nicholas R. Rhind

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Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription, Ying Feng, Yao Wang, Xiangnan Wang, Xiaohui He, Chen Yang, Ardalan Naseri, Thoru Pederson, Jing Zheng, Shaojie Zhang, Xiao Xiao, Wei Xie, and Hanhui Ma

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Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription [preprint], Ying Feng, Yao Wang, Xiangnan Wang, Xiaohui He, Chen Yang, Ardalan Naseri, Thoru Pederson, Jing Zheng, Shaojie Zhang, Xiao Xiao, Wei Xie, and Hanhui Ma

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Large domains of heterochromatin direct the formation of short mitotic chromosome loops, Maximilian H. Fitz-James, Pin Tong, Alison L. Pidoux, Hakan Ozadam, Liyan Yang, Sharon A. White, Job Dekker, and Robin C. Allshire

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence, Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Ines Fragata, David Mavor, Carl Hollins III, Claudia Bank, and Daniel N. Bolon

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Early life lessons: The lasting effects of germline epigenetic information on organismal development, Carolina Galan, Marina Krykbaeva, and Oliver J. Rando

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Cytosine methylation dynamics during post-testicular sperm maturation in mammals [preprint], Carolina Galan, Ryan W. Serra, Fengyun Sun, Vera Rinaldi, Colin C. Conine, and Oliver J. Rando

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Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism [preprint], Christl Gaubitz, Xingchen Liu, Joseph Magrino, Nicholas P. Stone, Jacob Landeck, Mark Hedglin, and Brian A. Kelch

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Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts, Stephen S. Gisselbrecht, Alexandre Palagi, Jesse V. Kurland, Julia M. Rogers, Hakan Ozadam, Ye Zhan, Job Dekker, and Martha L. Bulyk (Molecular cell, 2020-01-16)

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A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry, Janelle A. Hayes, Brendan J. Hilbert, Christl Gaubitz, Nicholas P. Stone, and Brian A. Kelch

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Mechanisms and Functions of Chromosome Compartmentalization, Erica M. Hildebrand and Job Dekker

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Structural Mechanism of Substrate Specificity In Human Cytidine Deaminase Family APOBEC3s, Shurong Hou

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Highly Effective Near-Infrared Activating Triplet-Triplet Annihilation Upconversion for Photoredox Catalysis, Ling Huang, Wenting Wu, Yang Li, Kai Huang, Le Zeng, Wenhai Lin, and Gang Han

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Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly, Shijie Huang, Nikolay A. Aleksashin, Anna B. Loveland, Dorota Klepacki, Kaspar Reier, Amira Kefi, Teresa Szal, Jaanus Remme, Luc Jaeger, Nora Vazquez-Laslop, Andrei A. Korostelev, and Alexander S. Mankin

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Succination inactivates gasdermin D and blocks pyroptosis, Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Carolina Ionete, Paul R. Thompson, and Katherine A. Fitzgerald

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The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation [preprint], Anthony N. Imbalzano, Hanna Witwicka, and Tapan Sharma

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CryoEM Structure of CtBP2 Confirms Tetrameric Architecture [preprint], Anne M. Jecrois, M. Michael Dcona, Xiaovan Deng, Dipankar Bandyopadhyay, Steven R. Grossman, Celia A. Schiffer, and William E. Royer

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Cryo-EM Structure of CtBP2 Confirms Tetrameric Architecture, Anne M. Jecrois, M. Michael Dcona, Xiaoyan Deng, Dipankar Bandyopadhyay, Steven R. Grossman, Celia A. Schiffer, and William E. Royer Jr.

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Thermus thermophilus Argonaute Functions in the Completion of DNA Replication, Samson M. Jolly, Ildar Gainetdinov, , Han Zhang, Lara Strittmatter, Shannon M. Bailey, Gregory M. Hendricks, Avantika Dhabaria, Beatrix Ueberheide, and Phillip D. Zamore

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Histone exchange is associated with activator function at transcribed promoters and with repression at histone loci, Sari Kassem, Paolo Ferrari, Amanda L. Hughes, Julien Soudet, Oliver J. Rando, and Michel Strubin

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STRIDE-a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells, Magdalena M. Kordon, Miroslaw Zarebski, Kamil Solarczyk, Hanhui Ma, Thoru Pederson, and Jurek W. Dobrucki

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Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways, Carrie A. Kovalak

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Ultrastructural Details of Mammalian Chromosome Architecture, Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar Abdennur, Johan H. Gibcus, Tsung-Han S. Hsieh, Krishna M. Parsi, Liyan Yang, Rene Maehr, Leonid A. Mirny, Job Dekker, and Oliver J. Rando (Molecular cell, 2020-03-14)

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Deciphering complex mechanisms of resistance and loss of potency through coupled molecular dynamics and machine learning [preprint], Florian Leidner, Nese Kurt Yilmaz, and Celia A. Schiffer

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Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome, Guangyuan Li, Coleman H. Young, Bryce Snow, Amanda O. Christensen, M. Kristen Demoruelle, Venkatesh V. Nemmara, Paul R. Thompson, Heather M. Rothfuss, and Brian D. Cherrington

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Molecular Mechanisms of Resistance and Structure-Based Drug Design in Homodimeric Viral Proteases, Gordon J. Lockbaum

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Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures, Gordon J. Lockbaum, Florian Leidner, William E. Royer, Nese Kurt Yilmaz, and Celia A. Schiffer

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The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson

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Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1, Heather S. Loring, Janneke D. Icso, Venkatesh V. Nemmara, and Paul R. Thompson

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Identification of the first noncompetitive SARM1 inhibitors, Heather S. Loring, Sangram Parelkar, Santanu Mondal, and Paul R. Thompson

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Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases, Heather S. Loring and Paul R. Thompson

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Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM [preprint], Anna B. Loveland, Egor Svidritskiy, Denis Susorov, Soojin Lee, Alexander Park, Gabriel Demo, Fen-Biao Gao, and Andrei A. Korostelev

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Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains, Atanu Maiti, Wazo Myint, Krista A. Delviks-Frankenberry, Shurong Hou, Tapan Kanai, Vanivilasini Balachandran, Christina Sierra Rodriguez, Rashmi Tripathi, Nese Kurt Yilmaz, Vinay K. Pathak, Celia A. Schiffer, and Hiroshi Matsuo

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Methods for detecting PER2::LUCIFERASE bioluminescence rhythms in freely moving mice [preprint], B. Martin-Burgos, W. Wang, I. William, S. Tir, I. Mohammad, R. Javed, Smith College, Y. Cui, Ciearra B. Smith, V. van der Vinne, P.C. Molyneux, Stephen C. Miller, David R. Weaver, T.L. Leise, and M.E. Harrington

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Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors, Ashley N. Matthew, Jacqueto Zephyr, Nageswara Rao Desaboini, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity [preprint], Ejemel Monir, Qi Li, Shurong Hou, Zachary Schiller, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Jacqueline R. Toomey, Ryan Schneider, Lisa Cavacini, Mark S. Klempner, Celia A. Schiffer, and Yan Wang

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A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction, Ejemel Monir, Qi Li, Shurong Hou, Zachary Schiller, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Jacqueline R. Toomey, Ryan Schneider, Anudeep S. Ramchetty, Chandrashekar Ganesa, Lisa Cavacini, Mark S. Klempner, Celia A. Schiffer, and Yan Wang

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Chromosome-scale assembly of the coral endosymbiont Symbiodinium microadriaticum genome provides insight into the unique biology of dinoflagellate chromosomes [preprint], Ankita Nand, Ye Zhan, Octavio R. Salazar, Manuel Aranda, Christian R. Voolstra, and Job Dekker

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Genome information processing by the INO80 chromatin remodeler positions nucleosomes [preprint], Elisa Oberbeckmann, Nils Krietenstein, Vanessa Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, Tobias Straub, Remo Rohs, Karl-Peter Hopfner, Philipp Korber, and Sebastian Eustermann

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Detecting chromatin interactions along and between sister chromatids with SisterC [preprint], Marlies E. Oomen, Adam K. Hedger, Jonathan K. Watts, and Job Dekker

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Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans, Deniz M. Ozata, Tianxiong Yu, Haiwei Mou, Ildar Gainetdinov, Cansu Colpan, Katharine Cecchini, Yasin Kaymaz, Pei-Hsuan Wu, Kaili Fan, Alper Kucukural, Zhiping Weng, and Phillip D. Zamore

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CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis, Teresita Padilla-Benavides, Dominic T. Haokip, Yeonsoo Yoon, Pablo Reyes-Gutierrez, Jaime A. Rivera, and Anthony N. Imbalzano

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Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis, Teresita Padilla-Benavides, Pablo Reyes-Gutierrez, and Anthony N. Imbalzano

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Viral Packaging ATPases Utilize a Glutamate Switch to Couple ATPase Activity and DNA Translocation [preprint], Joshua Pajak, Rockney Atz, Brendan J. Hilbert, Marc C. Morais, Brian A. Kelch, and Paul Jardine

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Atomistic Mechanism of Force Generation, Translocation, and Coordination in a Viral Genome Packaging Motor [preprint], Joshua Pajak, Erik Dill, Mark A. White, Brian A. Kelch, Paul Jardine, Gaurav Arya, and Marc C. Morais

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PFN1 phosphorylation marks protein aggregation and white matter pathology in ALS, Sepideh Parsi, Tao Qiao, Lyle Wilfred Ostrow, Marco B. Rust, and Zuoshang Xu

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Coronavirus conversations, in a time of logarithm, Thoru Pederson

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Publishing coronavirology: Peering into peer(less?) review, Thoru Pederson

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The 50th anniversary of reverse transcriptase-and its ironic legacy in the time of coronavirus, Thoru Pederson

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The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility, Pei-Hsuan Wu, Yu Fu, Katharine Cecchini, Deniz M. Ozata, Amena Arif, Tianxiong Yu, Cansu Colpan, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore

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An atlas of cell types in the mammalian epididymis and vas deferens [preprint], Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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An atlas of cell types in the mouse epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando

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Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere, Linah Rusere, Gordon J. Lockbaum, Mina Henes, Sook-Kyung Lee, Ean Spielvogel, Desaboini Nageswara Rao, Klajdi Kosovrasti, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, and Akbar Ali

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Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome [preprint], Sean P. Ryder

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Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice, Fernanda M. C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, and Lut Overbergh

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Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors, Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, and Xin Zhiguo Li

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Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis, Yuzi Tian, Santanu Mondal, Paul R. Thompson, and Yongqing Li

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Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir, Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, and Celia A. Schiffer

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Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines, Pinar Uysal-Onganer, Amy MacLatchy, Rayan Mahmoud, Igor Kraev, Paul R. Thompson, Jameel M. Inal, and Sigrun Lange

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Performance of ZDOCK and IRAD in CAPRI rounds 39-45, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Jennifer C. Gaines, and Zhiping Weng

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Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication Timing [preprint], Weitao Wang, Kyle Klein, Karel Proesmans, Northwestern University, Claire Marchal, Xiaopeng Zhu, Tyler M. Borrman, Alex Hastie, Zhiping Weng, Simon Fraser University, Paris Sciences et Lettres University, Florida State University, and Nicholas R. Rhind

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HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban

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Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock, Zhenyu Wu, Qiufang Deng, Baihong Pan, Hasan B. Alam, Yuzi Tian, Umar F. Bhatti, Baoling Liu, Santanu Mondal, Paul R. Thompson, and Yongqing Li

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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant, Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B Egri, James B. Munro, Pardis C. Sabeti, Christos A. Kyratsous, Natalya V. Dudkina, Kuang Shen, and Jeremy Luban

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SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain [preprint], Leonid Yurkovetskiy, Thomas Nyalile, Yetao Wang, William E. Diehl, Ann Dauphin, Claudia Carbone, Kristen Veinotte, Shawn B. Egri, Pardis C. Sabeti, Christos Kyratsous, James B. Munro, Kuang Shen, and Jeremy Luban

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PAD2 Dysregulation and Abnormal Protein Citrullination in ALS Disease Models, Issa Yusuf, Tao Qiao, Ronak Tilvawala, Paul R. Thompson, and Zuoshang Xu

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rad21 Is Involved in Corneal Stroma Development by Regulating Neural Crest Migration, Bi Ning Zhang, Yu Liu, Qichen Yang, Pui Ying Leung, Chengdong Wang, Thomas Chi Wong Bun, Clement C. Tham, Sun On Chan, Chi Pui Pang, Li Jia Chen, Job Dekker, Hui Zhao, and Wai Kit Chu