Title
Mapping Billions of Short Reads to a Reference Genome
UMMS Affiliation
Program in Bioinformatics and Integrative Biology; Department of Biochemistry and Molecular Pharmacology
Publication Date
2016-01-03
Document Type
Article
Disciplines
Bioinformatics | Computational Biology | Genomics | Molecular Biology
Abstract
Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.
DOI of Published Version
10.1101/pdb.top093153
Source
Cold Spring Harb Protoc. 2017 Jan 3;2017(1):pdb.top093153. doi: 10.1101/pdb.top093153. Link to article on publisher's site
Journal/Book/Conference Title
Cold Spring Harbor protocols
Related Resources
PubMed ID
27574203
Repository Citation
Hung, Jui-Hung and Weng, Zhiping, "Mapping Billions of Short Reads to a Reference Genome" (2016). Program in Bioinformatics and Integrative Biology Publications and Presentations. 90.
https://escholarship.umassmed.edu/bioinformatics_pubs/90