Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
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Authors
Carone, Benjamin R.Fauquier, Lucas
Habib, Naomi
Shea, Jeremy
Hart, Caroline E.
Li, Ruowang
Bock, Christoph
Li, Chengjian
Gu, Hongcang
Zamore, Phillip D.
Meissner, Alexander
Weng, Zhiping
Hofmann, Hans A.
Friedman, Nir
Rando, Oliver J.
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Bioinformatics and Integrative Biology
Document Type
Journal ArticlePublication Date
2010-12-23Keywords
AnimalsBiosynthetic Pathways
Cholesterol
Cytosine
*DNA Methylation
*Diet, Protein-Restricted
Gene Expression Profiling
Gene Expression Regulation, Developmental
*Genomic Imprinting
Humans
*Lipid Metabolism
Liver
Male
Mice
Biochemical Phenomena, Metabolism, and Nutrition
Bioinformatics
Computational Biology
Genetic Phenomena
Genetics and Genomics
Systems Biology
Metadata
Show full item recordAbstract
Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased levels of cholesterol esters, relative to the offspring of males fed a control diet. Epigenomic profiling of offspring livers revealed numerous modest ( approximately 20%) changes in cytosine methylation depending on paternal diet, including reproducible changes in methylation over a likely enhancer for the key lipid regulator Ppara. These results, in conjunction with recent human epidemiological data, indicate that parental diet can affect cholesterol and lipid metabolism in offspring and define a model system to study environmental reprogramming of the heritable epigenome.Source
Cell. 2010 Dec 23;143(7):1084-96. doi: 10.1016/j.cell.2010.12.008. Link to article on publisher's site
DOI
10.1016/j.cell.2010.12.008Permanent Link to this Item
http://hdl.handle.net/20.500.14038/25886PubMed ID
21183072Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2010.12.008