Title

Ancestry-inclusive dog genomics challenges popular breed stereotypes

UMMS Affiliation

Program in Bioinformatics and Integrative Biology; Morningside Graduate School of Biomedical Sciences; Program in Molecular Medicine

Publication Date

2022-04-29

Document Type

Article

Disciplines

Biochemistry, Biophysics, and Structural Biology | Bioinformatics | Computational Biology | Ecology and Evolutionary Biology | Genetics and Genomics | Integrative Biology | Systems Biology

Abstract

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h(2)) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.

DOI of Published Version

10.1126/science.abk0639

Source

Morrill K, Hekman J, Li X, McClure J, Logan B, Goodman L, Gao M, Dong Y, Alonso M, Carmichael E, Snyder-Mackler N, Alonso J, Noh HJ, Johnson J, Koltookian M, Lieu C, Megquier K, Swofford R, Turner-Maier J, White ME, Weng Z, Colubri A, Genereux DP, Lord KA, Karlsson EK. Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science. 2022 Apr 29;376(6592):eabk0639. doi: 10.1126/science.abk0639. Epub 2022 Apr 29. PMID: 35482869. Link to article on publisher's site

Journal/Book/Conference Title

Science (New York, N.Y.)

Comments

Full author list omitted for brevity. For the full list of authors, see article.

Related Resources

Link to Article in PubMed

PubMed ID

35482869

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