Program in Bioinformatics and Integrative Biology; Graduate School of Biomedical Sciences
Amino Acids, Peptides, and Proteins | Biochemistry, Biophysics, and Structural Biology | Bioinformatics | Computational Biology | Genetics and Genomics
MafB (a bZIP transcription factor), ss-catenin (the ultimate target of the Wnt signal transduction pathway that acts as a transcriptional co-activator of LEF/TCF proteins), and WDR77 (a transcriptional co-activator of multiple hormone receptors) are important for breast cellular transformation. Unexpectedly, these proteins interact directly with each other, and they have similar genomic binding profiles. Furthermore, while some of these common target sites coincide with those bound by LEF/TCF, the majority are located just downstream of transcription initiation sites at a position near paused RNA polymerase (Pol II) and the +1 nucleosome. Occupancy levels of these factors at these promoter-proximal sites are strongly correlated with the level of paused Pol II and transcriptional activity.
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Copyright © 2022 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
He L, Gao M, Pratt H, Weng Z, Struhl K. MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles. PLoS One. 2022 Apr 28;17(4):e0264799. doi: 10.1371/journal.pone.0264799. PMID: 35482762; PMCID: PMC9049301. Link to article on publisher's site
He L, Gao M, Pratt HE, Weng Z, Struhl K. (2022). MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles. Program in Bioinformatics and Integrative Biology Publications. https://doi.org/10.1371/journal.pone.0264799. Retrieved from https://escholarship.umassmed.edu/bioinformatics_pubs/176
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