UMMS Affiliation
Department of Microbiology and Physiological Systems; Program in Bioinformatics and Integrative Biology
Publication Date
2022-06-01
Document Type
Article
Disciplines
Diagnosis | Infectious Disease | Pediatrics | Virus Diseases | Viruses
Abstract
Rapid diagnostic tools for children with Ebola virus disease (EVD) are needed to expedite isolation and treatment. To evaluate a predictive diagnostic tool, we examined retrospective data (2014-2015) from the International Medical Corps Ebola Treatment Centers in West Africa. We incorporated statistically derived candidate predictors into a 7-point Pediatric Ebola Risk Score. Evidence of bleeding or having known or no known Ebola contacts was positively associated with an EVD diagnosis, whereas abdominal pain was negatively associated. Model discrimination using area under the curve (AUC) was 0.87, which outperforms the World Health Organization criteria (AUC 0.56). External validation, performed by using data from International Medical Corps Ebola Treatment Centers in the Democratic Republic of the Congo during 2018-2019, showed an AUC of 0.70. External validation showed that discrimination achieved by using World Health Organization criteria was similar; however, the Pediatric Ebola Risk Score is simpler to use.
Keywords
Ebola virus disease, West Africa, children, risk prediction score, viruses
Rights and Permissions
Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
DOI of Published Version
10.3201/eid2806.212265
Source
Genisca AE, Chu TC, Huang L, Gainey M, Adeniji M, Mbong EN, Kennedy SB, Laghari R, Nganga F, Muhayangabo RF, Vaishnav H, Perera SM, Colubri A, Levine AC, Michelow IC. Risk Prediction Score for Pediatric Patients with Suspected Ebola Virus Disease. Emerg Infect Dis. 2022 Jun;28(6):1189-1197. doi: 10.3201/eid2806.212265. PMID: 35608611; PMCID: PMC9155869. Link to article on publisher's site
Journal/Book/Conference Title
Emerging infectious diseases
Related Resources
PubMed ID
35608611
Repository Citation
Genisca AE, Chu T, Huang L, Gainey M, Adeniji M, Mbong EN, Kennedy SB, Laghari R, Nganga F, Muhayangabo RF, Vaishnav H, Perera SM, Colubri A, Levine AC, Michelow IC. (2022). Risk Prediction Score for Pediatric Patients with Suspected Ebola Virus Disease. Program in Bioinformatics and Integrative Biology Publications. https://doi.org/10.3201/eid2806.212265. Retrieved from https://escholarship.umassmed.edu/bioinformatics_pubs/172
Included in
Diagnosis Commons, Infectious Disease Commons, Pediatrics Commons, Virus Diseases Commons, Viruses Commons