Nordic OCD and Related Disorders Consortium: Rationale, design, and methods
Program in Bioinformatics and Integrative Biology; Program in Molecular Medicine
Computational Biology | Genomics | Integrative Biology | Medical Genetics | Mental Disorders | Nervous System Diseases | Psychiatry and Psychology
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is unknown and treatment outcomes could be improved if biological targets could be identified. Unfortunately, genetic findings for OCD are lagging behind other psychiatric disorders. Thus, there is a pressing need to understand the causal mechanisms implicated in OCD in order to improve clinical outcomes and to reduce morbidity and societal costs. Specifically, there is a need for a large-scale, etiologically informative genetic study integrating genetic and environmental factors that presumably interact to cause the condition. The Nordic countries provide fertile ground for such a study, given their detailed population registers, national healthcare systems and active specialist clinics for OCD. We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases. Our specific aims are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD. This article describes and discusses the rationale, design, and methodology of NORDiC, including details on clinical measures and planned genomic analyses.
Denmark, GWAS, Norway, OCD, Sweden, genetic
DOI of Published Version
Am J Med Genet B Neuropsychiatr Genet. 2019 Aug 19. doi: 10.1002/ajmg.b.32756. [Epub ahead of print] Link to article on publisher's site
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Mataix-Cols, David; Hansen, Bjarne; Mattheisen, Manuel; Karlsson, Elinor K.; Addington, Anjene M.; Boberg, Julia; Djurfeldt, Diana R.; Halvorsen, Matthew; Lichtenstein, Paul; Solem, Stian; Lindblad-Toh, Kerstin; Haavik, Jan; Kvale, Gerd; Ruck, Christian; and Crowley, James J., "Nordic OCD and Related Disorders Consortium: Rationale, design, and methods" (2019). Program in Bioinformatics and Integrative Biology Publications and Presentations. 152.