The Program in Bioinformatics and Integrative Biology (BIB) was established in 2008 at the University of Massachusetts Medical School to address one of the most dynamic and central areas in biomedical research—the ever-increasing quantity of molecular information available to scientists. Research in the BIB Program will include systems biology, computational modeling of regulatory and metabolic networks, docking, comparative genomics, protein design, genomic and proteomic biotechnology, microarray engineering and analysis, pharmacogenomics, structural biology, large scale modeling of biological systems, RNA, computational studies of cancer and neurological disorders and functional genomics, synthetic gene networks and molecular computing and genetics. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Program in Bioinformatics and Integrative Biology.
Publications from 2022
Factorbook: an updated catalog of transcription factor motifs and candidate regulatory motif sites, Henry E. Pratt, Gregory Andrews, Nishigandha Phalke, Michael J. Purcaro, Arjan van der Velde, Jill E. Moore, and Zhiping Weng
Containing the spread of mumps on college campuses, Mirai Shah, Gabrielle Ferra, Susan Fitzgerald, Paul J. Barreira, Pardis C. Sabeti, and Andres Colubri
The case for altruism in institutional diagnostic testing, Ivan Specht, Kian Sani, Yolanda Botti-Lodovico, Michael Hughes, Kristin Heumann, Amy Bronson, John Marshall, Emily Baron, Eric Parrie, Olivia Glennon, Ben Fry, Andres Colubri, and Pardis C. Sabeti
Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing, I-Hao Wang, Gregory Andrews, Elisa Donnard, Violeta Duran-Laforet, Travis E. Faust, Manuel Garber, Christina E. Baer, Dorothy P. Schafer, Zhiping Weng, and Paul L. Greer
Publications from 2021
Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics, Houda Belaghzal, Tyler M. Borrman, Andrew D. Stephens, Denis L. Lafontaine, Sergey V. Venev, Zhiping Weng, John F. Marko, and Job Dekker
Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science, Frances L. Chen, Madeline Zimmermann, Jessica P. Hekman, Kathryn A. Lord, Brittney Logan, Jane Russenberger, Eldin A. Leighton, and Elinor K. Karlsson
Genetic and epigenetic features of promoters with ubiquitous chromatin accessibility support ubiquitous transcription of cell-essential genes, Kaili Fan, Jill E. Moore, Xiao-Ou Zhang, and Zhiping Weng
Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK, Michael P. Gallagher, James M. Conley, Pranitha Vangala, Manuel Garber, Andrea Reboldi, and Leslie J. Berg
Network analysis of human vitiligo scRNA-seq data reveals complex mechanisms of immune activation, Kyle Gellatly
scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function, Kyle Gellatly, James P. Strassner, Kingsley I. Essien, Maggi Ahmed Refat, Rachel L. Murphy, Anthony Coffin-Schmitt, Michael L. Frisoli, Xueli Fan, Evangeline E. Kim, Zainab Abbas, Patrick McDonel, Manuel Garber, and John E. Harris
Simultaneous profiling of multiple chromatin proteins in the same cells, Sneha Gopalan, Yuqing Wang, Nicholas W. Harper, Manuel Garber, and Thomas G. Fazzio
Simultaneous profiling of multiple chromatin proteins in the same cells [preprint], Sneha Gopalan, Yuqing Wang, Nicholas W. Harper, Manuel Garber, and Thomas G. Fazzio
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants, Johnathan D. Guest, Thom Vreven, Jing Zhou, Iain Moal, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Zhiping Weng, and Brian G. Pierce
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation, Lizhi He, Henry E. Pratt, Mingshi Gao, Fengxiang Wei, Zhiping Weng, and Kevin Struhl
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation [preprint], Lizhi He, Henry E. Pratt, Fengxiang Wei, Mingshi Gao, Zhiping Weng, and Kevin Struhl
Complex feline disease mapping using a dense genotyping array [preprint], Isabel Hernandez, Jessica J. Hayward, and Michelle E. White
March Mammal Madness and the power of narrative in science outreach, Katie Hinde and Elinor K. Karlsson
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders, Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind, PsychENCODE Consortium, Eugenio Mattei, Michael J. Purcaro, Zhiping Weng, Jill E. Moore, Henry E. Pratt, Jack Huey, and Tyler M. Borrman
Deletion and replacement of long genomic sequences using prime editing, Tingting Jiang, Xiao-Ou Zhang, Zhiping Weng, and Wen Xue
Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions, Jong Hyuk Kim, Kate Megquier, Rachael Thomas, Aaron L. Sarver, Jung Min. Song, Yoon Tae Kim, Nuojin Cheng, Ashley J. Schulte, Michael A. Linden, Paari Murugan, LeAnn Oseth, Colleen L. Forster, Ingegerd Elvers, Ross Swofford, Jason Turner-Maier, Elinor K. Karlsson, Matthew Breen, Kerstin Lindblad-Toh, and Jaime F. Modiano
Sciviewer enables interactive visual interrogation of single-cell RNA-Seq data from the python programming environment, Dylan Kotliar and Andres Colubri
Sciviewer enables interactive visual interrogation of single-cell RNA-Seq data from the Python programming environment [preprint], Dylan Kotliar and Andres Colubri
Gaining Insight into Vitiligo Genetics through the Lens of a Large Epidemiologic Study, Ken Okamura, Manuel Garber, and John E. Harris
The testis-specific transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in placental mammals [preprint], Deniz M. Ozata, Tianxiong Yu, Katharine Cecchini, Haiwei Mou, Amena Arif, Cansu Colpan, Adriano Biasini, Ildar Gaitendinov, Dirk G. de Rooij, Zhiping Weng, and Phillip D. Zamore
Factorbook: an Updated Catalog of Transcription Factor Motifs and Candidate Regulatory Motif Sites [preprint], Henry E. Pratt, Gregory Andrews, Nishigandha Phalke, Michael J. Purcaro, Arjan van der Velde, Jill E. Moore, and Zhiping Weng
Type I IFN-Driven Immune Cell Dysregulation in Rat Autoimmune Diabetes, Natasha Qaisar, Adediwura Arowosegbe, Alan G. Derr, Alper Kucukural, Basanthi Satish, Riccardo Racicot, Zhiru Guo, Melanie I. Trombly, and Jennifer P. Wang
Multi-tissue integrative analysis of personal epigenomes [preprint], Joel Rozowsky, Jill E. Moore, Henry E. Pratt, Zhiping Weng, and Mark Gerstein
The Case for Altruism in Institutional Diagnostic Testing [preprint], Ivan Specht, Kian Sani, Yolanda Botti-Lodovico, Michael Hughes, Kristin Heumann, Amy Bronson, John Marshall, Emily Baron, Eric Parrie, Olivia Glennon, Ben Fry, Andres Colubri, and Pardis C. Sabeti
Genome-wide association study identifies new locus associated with OCD [preprint], Nora I. Strom, Elinor K. Karlsson, and Manuel Mattheisen
Annotation of chromatin states in 66 complete mouse epigenomes during development, Arjan van der Velde, Kaili Fan, Junko Tsuji, Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, and Zhiping Weng
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes, Tianxiong Yu, Kaili Fan, Deniz M. Ozata, Gen Zhang, Yu Fu, William E. Theurkauf, Phillip D. Zamore, and Zhiping Weng
A benchmark and an algorithm for detecting germline transposon insertions and measuring de novo transposon insertion frequencies, Tianxiong Yu, Xiao Huang, Shengqian Dou, Xiaolu Tang, Shiqi Luo, William E. Theurkauf, Jian Lu, and Zhiping Weng
piRNA-independent transposon silencing by the Drosophila THO complex, Gen Zhang, Tianxiong Yu, Swapnil Parhad, Samantha Ho, Zhiping Weng, and William E. Theurkauf
Investigating the Potential Roles of SINEs in the Human Genome, Xiao-Ou Zhang, Henry E. Pratt, and Zhiping Weng
Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs, Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G. Clohessy, and Pier Paolo Pandolfi
Publications from 2020
Progressive Cactus is a multiple-genome aligner for the thousand-genome era, Joel Armstrong, Elinor K. Karlsson, Guojie Zhang, and Benedict Paten
Measuring Stability of 3D Chromatin Conformations and Identifying Neuron Specific Chromatin Loops Associated with Schizophrenia Risk, Tyler M. Borrman
High-throughput modeling and scoring of TCR-pMHC complexes to predict cross-reactive peptides, Tyler M. Borrman, Brian G. Pierce, Thom Vreven, Brian M. Baker, and Zhiping Weng
Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults [preprint], Yuming Cao, Zhiru Guo, Pranitha Vangala, Elisa Donnard, Ping Liu, Patrick McDonel, Jose Ordovas Montanes, Alex K. Shalek, Robert W. Finberg, Jennifer P. Wang, and Manuel Garber
Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal, Alison P. Casserly, Junko Tsuji, Rubing Zhao-Shea, Ciearra B. Smith, Susanna Molas-Casacuberta, Andrew R. Tapper, Zhiping Weng, and Paul D. Gardner
Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution, Gaurav Chauhan, Jesse McClure, Jessica Hekman, Patrick W. Marsh, Jeffrey A. Bailey, Rachel F. Daniels, Diane P. Genereux, and Elinor K. Karlsson
ORAN: A meta-modeling platform to drive real-life and online outbreak simulations, Andres Colubri
Preventing Outbreaks through Interactive, Experiential Real-Life Simulations, Andres Colubri, Molly Kemball, Kian Sani, Chloe Boehm, Karen Mutch-Jones, Ben Fry, Todd Brown, and Pardis C. Sabeti
The meadow jumping mouse genome and transcriptome suggest mechanisms of hibernation [preprint], Qian Cong, Ethan A. Brem, Jing Zhang, Jessica Alfoldi, Jeremy Johnson, Elinor K. Karlsson, Kerstin Lindblad-Toh, Jason L. Malaney, and William J. Israelsen
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates, Joana Damas, Elinor K. Karlsson, and Harris A. Lewin
Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates [preprint], Joana Damas, Elinor K. Karlsson, and Harris A. Lewin
Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome model [preprint], Elisa Donnard, Huan Shu, and Manuel Garber
Bioinformatics Core Survey Highlights the Challenges Facing Data Analysis Facilities, Julie A. Dragon, Chris Gates, Shannan Ho Sui, John N. Hutchinson, R. Krishna Murthy Karuturi, Alper Kucukural, Shawn Polson, Alberto Riva, Matthew Lee Settles, Jyothi Thimmapuram, and Stuart S. Levine
Expanded encyclopaedias of DNA elements in the human and mouse genomes, ENCODE Project Consortium, Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, Xiao-Ou Zhang, Shaimae I. Elhajjajy, Jack Huey, Job Dekker, J. Michael Cherry, Richard M. Myers, Bing Ren, Brenton R. Graveley, Mark B. Gerstein, Len A. Pennacchio, Michael P. Snyder, Bradley E. Bernstein, Barbara Wold, Ross C. Hardison, Thomas R. Gingeras, John A. Stamatoyannopoulos, and Zhiping Weng
Perspectives on ENCODE, ENCODE Project Consortium, Michael P. Snyder, Jill E. Moore, and Zhiping Weng
A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons, Sergio Espeso-Gil, Tyler M. Borrman, Zhiping Weng, and Schahram Akbarian
Genetic and Epigenetic Features of Promoters with Ubiquitous Chromatin Accessibility Support Ubiquitous Transcription of Cell-essential Genes [preprint], Kaili Fan, Jill E. Moore, Xiao-Ou Zhang, and Zhiping Weng
The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction [preprint], Michael P. Gallagher, James M. Conley, Pranitha Vangala, Andrea Reboldi, Manuel Garber, and Leslie J. Berg
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope, Tingting Jiang, Xiao-Ou Zhang, Yueying Cao, Zhiping Weng, and Wen Xue
Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma, Yasin Kaymaz, Cliff I. Oduor, Ozkan Aydemir, Micah A. Luftig, Juliana A. Otieno, John Michael. Ong'echa, Jeffrey A. Bailey, and Ann M. Moormann
An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu
Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage in the Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, and Andrew B. Leiter
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale, Xihao Li, Jill E. Moore, Zhiping Weng, and Xihong Lin
The History of Farm Foxes Undermines the Animal Domestication Syndrome, Kathryn A. Lord, Greger Larson, Raymond P. Coppinger, and Elinor K. Karlsson
Transcriptomic profiling reveals extraordinary diversity of venom peptides in unexplored predatory gastropods of the genus Clavus, Aiping Lu, Maren Watkins, Qing Li, Samuel D. Robinson, Gisela P. Concepcion, Mark Yandell, Zhiping Weng, Baldomero M. Olivera, Helena Safavi-Hemami, and Alexander E. Fedosov
A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods, Jill E. Moore, Henry E. Pratt, Michael J. Purcaro, and Zhiping Weng
Proteomic and Transcriptional Profiles of Human Stem Cell-Derived beta Cells Following Enteroviral Challenge, Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, and Jennifer P. Wang
Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans, Deniz M. Ozata, Tianxiong Yu, Haiwei Mou, Ildar Gainetdinov, Cansu Colpan, Katharine Cecchini, Yasin Kaymaz, Pei-Hsuan Wu, Kaili Fan, Alper Kucukural, Zhiping Weng, and Phillip D. Zamore
Adaptive Evolution Targets a piRNA Precursor Transcription Network, Swapnil Parhad, Tianxiong Yu, Gen Zhang, Nicholas P. Rice, Zhiping Weng, and William E. Theurkauf
The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility, Pei-Hsuan Wu, Yu Fu, Katharine Cecchini, Deniz M. Ozata, Amena Arif, Tianxiong Yu, Cansu Colpan, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore
LogoJS: a Javascript package for creating sequence logos and embedding them in web applications, Henry E. Pratt and Zhiping Weng
Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice, Sambra D. Redick, Linda Leehy, Ann R. Rittenhouse, David M. Blodgett, Alan G. Derr, Alper Kucukural, Manuel Garber, Leonard D. Shultz, Dale L. Greiner, Jennifer P. Wang, David M. Harlan, Rita Bortell, and Agata Jurczyk
An atlas of cell types in the mammalian epididymis and vas deferens [preprint], Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando
An atlas of cell types in the mouse epididymis and vas deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, and Oliver J. Rando
FMRP Links Optimal Codons to mRNA stability in Neurons [preprint], Huan Shu, Elisa Donnard, Botao Liu, Ruijia Wang, and Joel D. Richter
YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells, Jordan L. Smith, Tomas Rodriguez, Haiwei Mou, Suet-Yan Kwan, Henry E. Pratt, Xiao-Ou Zhang, Yueying Cao, Shun-Qing Liang, Deniz M. Ozata, Tianxiong Yu, Qiangzong Yin, Max Hazeltine, Zhiping Weng, Erik J. Sontheimer, and Wen Xue
Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors, Yu H. Sun, Jiang Zhu, Li Huitong Xie, Ziwei Li, Rajyalakshmi Meduri, Xiaopeng Zhu, Chi Song, Chen Chen, Emiliano P. Ricci, Zhiping Weng, and Xin Zhiguo Li
Humanity's Best Friend: A Dog-Centric Approach to Addressing Global Challenges, Naomi Sykes, Elinor K. Karlsson, and Greger Larson
High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death, Junko Tsuji, Travis Thomson, Elizabeth Chan, Christine K. Brown, Julia Oppenheimer, Carol Bigelow, Xianjun Dong, William E. Theurkauf, Zhiping Weng, and Lawrence M. Schwartz
Role of Cis-regulatory Elements in Transcriptional Regulation: From Evolution to 4D Interactions, Pranitha Vangala
High-Resolution Mapping of Multiway Enhancer-Promoter Interactions Regulating Pathogen Detection, Pranitha Vangala, Rachel Murphy, Sofia A. Quinodoz, Kyle J. Gellatly, Patrick E. McDonel, Mitchell Guttman, and Manuel Garber
Performance of ZDOCK and IRAD in CAPRI rounds 39-45, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Jennifer C. Gaines, and Zhiping Weng
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells, Yetao Wang, Lawrence M. Lifshitz, Kyle Gellatly, Sean M. McCauley, Pranitha Vangala, Kyusik Kim, Alan G. Derr, Smita Jaiswal, Alper Kucukural, Patrick McDonel, Thomas C. Greenough, JeanMarie Houghton, Manuel Garber, and Jeremy Luban
DolphinNext: a distributed data processing platform for high throughput genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, and Alper Kucukural
Comprehensive identification of alternative back-splicing in human tissue transcriptomes, Peng Zhang, Xiao-Ou Zhang, Tingting Jiang, Lingling Cai, Xiao Huang, Qi Liu, Dan Li, Aiping Lu, Yan Liu, Wen Xue, Peng Zhang, and Zhiping Weng
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity, Xuming Zhou, Elinor K. Karlsson, and Vadim N. Gladyshev
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues, Carly G. K. Ziegler, Yuming Cao, Zhiru Guo, Jennifer P. Wang, Robert W. Finberg, Manuel Garber, Alex K. Shalek, Jose Ordovas-Montanes, and HCA Lung Biological Network
A comparative genomics multitool for scientific discovery and conservation, Zoonomia Consortium, Diane P. Genereux, Manuel Garber, Kerstin Lindblad-Toh, and Elinor K. Karlsson
Publications from 2019
Aquatic adaptation and depleted diversity: a deep dive into the genomes of the sea otter and giant otter, Annabel C. Beichman, Klaus-Peter Koepfli, Gang Li, William Murphy, Pasha Dobrynin, Sergei Kilver, M. Tim Tinker, Michael J. Murray, Jeremy Johnson, Kerstin Lindblad-Toh, Elinor K. Karlsson, Kirk E. Lohmueller, and Robert K. Wayne
Constrained mutational sampling of amino acids in HIV-1 protease evolution, Jeffrey I. Boucher, Troy W. Whitfield, Ann Dauphin, Gily S. Nachum, Carl Hollins III, Konstantin B. Zeldovich, Ronald Swanstrom, Celia A. Schiffer, Jeremy Luban, and Daniel N. Bolon
Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals, Nicholas R. Casewell, Elinor K. Karlsson, Daniel Petras, Daren C. Card, Vivek Suranse, Alexis M. Mychajliw, David Richards, Ivan Koludarov, Laura-Oana Albulescu, Julien Slagboom, Benjamin-Florian Hempel, Neville M. Ngum, Rosalind J. Kennerley, Jorge L. Brocca, and Gareth Whiteley
The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria, Daniel Tianfang Ge, Wei Wang, Cindy Tipping, Ildar Gainetdinov, Zhiping Weng, and Phillip D. Zamore
Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons, Fedor E. Gusev, Anastasia P. Grigorenko, Elena Filippova, Zhiping Weng, Schahram Akbarian, and Evgeny I. Rogaev
Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia, Fedor E. Gusev, Denis A. Reshetov, Amanda C. Mitchell, Tatiana V. Andreeva, Aslihan Dincer, Anastasia P. Grigorenko, Gennady Fedonin, Tobias Halene, Maria Aliseychik, Elena Filippova, Zhiping Weng, Schahram Akbarian, and Evgeny I. Rogaev
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance, Mina Henes, Klajdi Kosovrasti, Gordon J. Lockbaum, Florian Leidner, Gily S. Nachum, Ellen A. Nalivaika, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer, and Troy W. Whitfield
Epstein Barr virus genomes reveal population structure and type 1 association with endemic Burkitt lymphoma [preprint], Yasin Kaymaz, Cliff Oduor, Ozkan Aydemir, Micah Luftig, Juliana Otieno, John Michael Ong'echa, Jeffrey A. Bailey, and Ann M. Moormann
Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression, Barry Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, and Kenneth L. Rock
DolphinNext: A Graphical User Interface for Distributed Data Processing of High Throughput Genomics, Alper Kucukural
DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber
Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes, Suet-Yan Kwan, Ankur Sheel, Chun-Qing Song, Xiao-Ou Zhang, Tingting Jiang, Hien Dang, Yueying Cao, Deniz M. Ozata, Haiwei Mou, Hao Yin, Zhiping Weng, Xin Wei Wang, and Wen Xue
Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment, Marc F. Lensink, Thom Vreven, Sweta Vangaveti, Tyler M. Borrman, Zhiping Weng, and Shoshana J. Wodak
A unified encyclopedia of human functional DNA elements through fully automated annotation of 164 human cell types, Maxwell W. Libbrecht, Oscar L. Rodriguez, Zhiping Weng, Jeffrey A. Bilmes, Michael M. Hoffman, and William Stafford Noble
Nordic OCD and Related Disorders Consortium: Rationale, design, and methods, David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, and James J. Crowley
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma, Kate Megquier, Elinor K. Karlsson, and Kerstin Lindblad-Toh
BarkBase: Epigenomic Annotation of Canine Genomes, Kate Megquier, Xue Li, Kathleen Morrill, Brittney Logan, and Elinor K. Karlsson