Gastric tonometry in healthy volunteers: effect of ranitidine on calculated intramural pH
Department of Surgery; Department of Anesthesiology
*Gastric Acidity Determination; Humans; Methods; Ranitidine
Anesthesiology | Heterocyclic Compounds | Pharmaceutical Preparations | Therapeutics
OBJECTIVE: To determine if intraluminal production of CO2 leads to underestimation of gastric intramural pH (pHi) by tonometry.
DESIGN: Nonrandomized controlled study.
PATIENTS: Healthy volunteers.
INTERVENTIONS: NG tonometers were placed in healthy volunteers. Some of the volunteers (n = 11) were pretreated with ranitidine to prevent secretion of protons into the gastric lumen. Others (n = 13) were untreated (i.e., gastric acid secretion was uninhibited).
MEASUREMENTS AND MAIN RESULTS: Gastric pHi was calculated from the arterial (HCO3-) and the tonometrically determined intraluminal PCO2 using the Henderson-Hasselbalch equation. Intraluminal PCO2 was significantly higher in the control group (54 +/- 14 torr [7.2 +/- 1.9 kPa]) than in the ranitidine-treated group (42 +/- 4 torr [5.6 +/- 0.4 kPa], p = .02). Mean gastric luminal pH was 1.9 +/- 0.6 in the control group as compared with 6.7 +/- 0.7 in volunteers treated with ranitidine (p less than .01). Mean calculated gastric pHi was 7.30 +/- 0.11 in the untreated group and 7.39 +/- 0.03 in the ranitidine-treated group (p less than .03).
CONCLUSIONS: These data suggest that intraluminal production of CO2 from the titration of gastric HCO3- by secreted H+ can result in the underestimation of gastric pHi by tonometry. This phenomenon can be eliminated by H2-receptor blockade.
DOI of Published Version
Crit Care Med. 1991 Feb;19(2):271-4.
Critical care medicine
Heard SO, Helsmoortel CM, Kent JC, Shahnarian A, Fink MP. (1991). Gastric tonometry in healthy volunteers: effect of ranitidine on calculated intramural pH. Anesthesiology and Perioperative Medicine Publications. https://doi.org/10.1097/00003246-199102000-00025. Retrieved from https://escholarship.umassmed.edu/anesthesiology_pubs/42