Title

Bronchopulmonary segmental lavage with Surfaxin (KL(4)-surfactant) for acute respiratory distress syndrome

UMMS Affiliation

Department of Anesthesiology; Department of Surgery; Department of Medicine, Division of Pulmonary, Allergy And Critical Care Medicine

Publication Date

1999-10

Document Type

Article

Subjects

*Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Female; Humans; Male; Middle Aged; Peptides; Positive-Pressure Respiration; Proteins; Pulmonary Gas Exchange; Pulmonary Surfactants; Respiratory Distress Syndrome, Adult

Disciplines

Anesthesiology | Respiratory Tract Diseases

Abstract

We performed a trial to assess the safety and tolerability of sequential bronchopulmonary segmental lavage with a dilute synthetic surfactant (Surfaxin) in 12 adults with ARDS. Patients received one of three dosing regimens in which aliquots of Surfaxin were administered via a wedged bronchoscope to each of the 19 bronchopulmonary segments. Suctioning was performed 10-30 s after instillation of individual aliquots. Group 1 patients (n = 3) received one 30-ml aliquot of a 2.5-mg/ml concentration of Surfaxin in each segment, followed by a second 30-ml aliquot with a 10-mg/ml concentration. Group 2 patients (n = 4) received two 30-ml aliquots of the 2.5-mg/ml concentration followed by a third lavage with the 10-mg/ml concentration. Group 3 patients (n = 5) received therapy identical to that received by patients in Group 2 and were eligible for repeat dosing 6 to 24 h later. All patients tolerated the procedure. There were no serious adverse experiences ascribed to either the procedure or the surfactant. In the 96 h after treatment initiation, FI(O(2)) decreased from 0.80 to 0.52 and PEEP decreased from 10.3 to 7.6 cm H(2)O. Bronchoscopic "cleansing" of the lungs with dilute Surfaxin may offer a safe and feasible approach to improving outcomes in patients with ARDS. Wiswell TE, Smith RM, Katz LB, Mastroianni L, Wong DY, Willms D, Heard S, Wilson M, Hite RD, Anzueto A, Revak SD, Cochrane CG. Bronchopulmonary segmental lavage with Surfaxin (KL(4)-surfactant) for acute respiratory distress syndrome.

Source

Am J Respir Crit Care Med. 1999 Oct;160(4):1188-95.

Journal/Book/Conference Title

American journal of respiratory and critical care medicine

Related Resources

Link to Article in PubMed

PubMed ID

10508806

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