The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery
Authors
Talke, PekkaChen, Richard
Thomas, Brian
Aggarwall, Anil
Gottlieb, Alexandru
Thorborg, Per
Heard, Stephen O.
Cheung, Albert
Son, Stanley Lee
Kallio, Antero
Document Type
Journal ArticlePublication Date
2000-04-01Keywords
Adrenergic alpha-AgonistsAdult
Aged
Aged, 80 and over
Blood Pressure
Catecholamines
Clonidine
Dexmedetomidine
Double-Blind Method
Female
Heart Rate
Humans
Male
Middle Aged
Vascular Surgical Procedures
Anesthesia and Analgesia
Anesthesiology
Heterocyclic Compounds
Surgical Procedures, Operative
Metadata
Show full item recordAbstract
We tested dexmedetomidine, an alpha(2) agonist that decreases heart rate, blood pressure, and plasma norepinephrine concentration, for its ability to attenuate stress responses during emergence from anesthesia after major vascular operations. Patients scheduled for vascular surgery received either dexmedetomidine (n = 22) or placebo (n = 19) IV beginning 20 min before the induction of anesthesia and continuing until 48 h after the end of surgery. All patients received standardized anesthesia. Heart rate and arterial blood pressure were kept within predetermined limits by varying anesthetic level and using vasoactive medications. Heart rate, arterial blood pressure, and inhaled anesthetic concentration were monitored continuously; additional measurements included plasma and urine catecholamines. During emergence from anesthesia, heart rate was slower with dexmedetomidine (73 +/- 11 bpm) than placebo (83 +/- 20 bpm) (P = 0.006), and the percentage of time the heart rate was within the predetermined hemodynamic limits was more frequent with dexmedetomidine (P < 0.05). Plasma norepinephrine levels increased only in the placebo group and were significantly lower for the dexmedetomidine group during the immediate postoperative period (P = 0.0002). We conclude that dexmedetomidine attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia. IMPLICATIONS: The alpha(2) agonist, dexmedetomidine, attenuates increases in heart rate and plasma norepinephrine concentrations during emergence from anesthesia in vascular surgery patients.Source
Anesth Analg. 2000 Apr;90(4):834-9.
DOI
10.1213/00000539-200004000-00011Permanent Link to this Item
http://hdl.handle.net/20.500.14038/25791PubMed ID
10735784Related Resources
ae974a485f413a2113503eed53cd6c53
10.1213/00000539-200004000-00011