Department of Cell Biology
Medical Subject Headings
Aging; Cell Aging; Cell Transformation, Neoplastic; Neoplasms; Tumor Suppressor Proteins
Cancer Biology | Cell Biology | Cellular and Molecular Physiology
Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.
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Citation: Kong, Y., Cui, H., Ramkumar, C., and Zhang, H. (2011). Regulation of senescence in cancer and aging. Journal of Aging Research. doi:10.4061/2011/963172. Link to article on publisher's website