UMMS Affiliation

Department of Cell Biology

Date

1-12-2011

Document Type

Article

Medical Subject Headings

Aging; Cell Aging; Cell Transformation, Neoplastic; Neoplasms; Tumor Suppressor Proteins

Disciplines

Cancer Biology | Cell Biology | Cellular and Molecular Physiology

Abstract

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.

Rights and Permissions

Citation: Kong, Y., Cui, H., Ramkumar, C., and Zhang, H. (2011). Regulation of senescence in cancer and aging. Journal of Aging Research. doi:10.4061/2011/963172. Link to article on publisher's website

Comments

Copyright 2011 Yahui Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Co-author Charusheila Ramkumar is a student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to article in PubMed