UMass Chan Affiliations
Department of Cell BiologyDocument Type
Journal ArticlePublication Date
2011-01-12Keywords
AgingCell Aging
Cell Transformation, Neoplastic
Neoplasms
Tumor Suppressor Proteins
Cancer Biology
Cell Biology
Cellular and Molecular Physiology
Metadata
Show full item recordAbstract
Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.Source
Kong, Y., Cui, H., Ramkumar, C., and Zhang, H. (2011). Regulation of senescence in cancer and aging. Journal of Aging Research. doi:10.4061/2011/963172. Link to article on publisher's websiteDOI
10.4061/2011/963172Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51110PubMed ID
21423549Notes
Co-author Charusheila Ramkumar is a student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to article in PubMedRights
Copyright 2011 Yahui Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ae974a485f413a2113503eed53cd6c53
10.4061/2011/963172