This collection showcases the journal articles and other publications authored by researchers in the Zhang Lab in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2014

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Smurf2 regulates hematopoietic stem cell self-renewal and aging, Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang (Aging cell)

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Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma, Sally E. Trabucco, Rachel M. Gerstein, Andrew M. Evens, James E. Brander, Leonard D. Shultz, Dale Greiner, and Hong Zhang (Clinical Cancer Research)

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Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms, P. Tripathi, Y. Wang, M. Coussens, K. R. Manda, A. M. Casey, C. Lin, E. Poyo, J. D. Pfeifer, N. Basappa, C. M. Bates, L. Ma, Hong Zhang, M. Pan, L. Ding, and F. Chen (Oncogene)

Submissions from 2013

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Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence, Hang Cui, Yahui Kong, Mei Xu, and Hong Zhang (Cancer research)

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Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1, Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Nature communications)

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Serial Transplantation of Bone Marrow to Test Self-renewal Capacity of Hematopoietic Stem Cells In Vivo, Charusheila Ramkumar, Rachel M. Gerstein, and Hong Zhang (Methods in molecular biology (Clifton, N.J.))

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Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence, Eric C. Swanson, Benjamin J. Manning, Hong Zhang, and Jeanne B. Lawrence (The Journal of cell biology)

Submissions from 2012

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Oxidative stress, mitochondrial dysfunction, and aging, Hang Cui, Yahui Kong, and Hong Zhang (Journal of signal transduction)

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Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress, Raymond S. Oh, Wen-Chi Pan, Abdullah Yalcin, Hong Zhang, Tomas R. Guilarte, Gokhan S. Hotamisligil, David C. Christiani, and Quan Lu (The Journal of biological chemistry)

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang (Cancer research)

Submissions from 2011

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Regulation of senescence in cancer and aging, Yahui Kong, Hang Cui, Charusheila Ramkumar, and Hong Zhang (Journal of Aging Research)

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Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence, Yahui Kong, Hang Cui, and Hong Zhang (Aging cell)

Submissions from 2008

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Suppression of human tumor cell proliferation by Smurf2-induced senescence, Hong Zhang, Yuchin Teng, Yahui Kong, Paul E. Kowalski, and Stanley N. Cohen (Journal of cellular physiology)

Submissions from 2007

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Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging, Hong Zhang (Journal of cellular physiology)

Submissions from 2004

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Smurf2 up-regulation activates telomere-dependent senescence, Hong Zhang and Stanley N. Cohen (Genes and development)

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Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions, Hong Zhang, Brittney-Shea Herbert, Kuang-Hung Pan, Jerry W. Shay, and Stanley N. Cohen (Oncogene)

Submissions from 2003

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Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci, Hong Zhang, Kuang-Hung Pan, and Stanley N. Cohen (Proceedings of the National Academy of Sciences of the United States of America)

Submissions from 2002

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hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts, Ziqiang Li, Hong Zhang, Terrence p. McManus, J. Justin McCormick, Christopher W. Lawrence, and Veronica M. Maher (Mutation research)

Submissions from 2000

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Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts, Hong Zhang, Giancarlo Marra, Josef Jiricny, Veronica M. Maher, and J. Justin McCormick (Carcinogenesis)

Submissions from 1996

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O6-methylguanine induces intrachromosomal homologous recombination in human cells, Hong Zhang, Tohru Tsujimura, Natai P. Bhattacharyya, Veronica M. Maher, and J. Justin McCormick (Carcinogenesis)