Evaluation of reproductive function in women treated for bipolar disorder compared to healthy controls
Authors
Reynolds-May, Margaret F.Kenna, Heather A.
Marsh, Wendy K.
Stemmle, Pascale G.
Wang, Po
Ketter, Terence A.
Rasgon, Natalie L.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2013-11-22Keywords
bipolar disordereating disorder
hormones
menstrual abnormalities
polycystic ovary syndrome
reproductive function
women
Female Urogenital Diseases and Pregnancy Complications
Mental Disorders
Obstetrics and Gynecology
Psychiatry
Reproductive and Urinary Physiology
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVES: The purpose of the present study was to investigate the reproductive function of women with bipolar disorder (BD) compared to healthy controls. METHODS: Women diagnosed with BD and healthy controls with no psychiatric history, aged 18-45 years, were recruited from a university clinic and surrounding community. Participants completed a baseline reproductive health questionnaire, serum hormone assessment, and ovulation tracking for three consecutive cycles using urine luteinizing hormone (LH)-detecting strips with a confirmatory luteal-phase serum progesterone. RESULTS: Women with BD (n = 103) did not differ from controls (n = 36) in demographics, rates of menstrual abnormalities (MAs), or number of ovulation-positive cycles. Of the women with BD, 17% reported a current MA and 39% reported a past MA. Dehydroepiandrosterone sulfate and 17-hydroxyprogesterone levels were higher in controls (p = 0.052 and 0.004, respectively), but there were no other differences in biochemical levels. Medication type, dose, or duration was not associated with MA or biochemical markers, although those currently taking an atypical antipsychotic agent indicated a greater rate of current or past MA (80% versus 55%, p = 0.013). In women with BD, 22% reported a period of amenorrhea associated with exercising or stress, versus 8% of controls (p = 0.064). Self-reported rates of bulimia and anorexia nervosa were 10% and 5%, respectively. CONCLUSIONS: Rates of MA and biochemical levels did not significantly differ between women with BD and controls. Current atypical antipsychotic agent use was associated with a higher rate of current or past MA and should be further investigated. The incidence of stress-induced amenorrhea should be further investigated in this population, as should the comorbid incidence of eating disorders.Source
Reynolds-May MF, Kenna HA, Marsh W, Stemmle PG, Wang P, Ketter TA, Rasgon NL . Evaluation of reproductive function in women treated for bipolar disorder compared to healthy controls. Bipolar Disord. 2013 Nov 22. doi: 10.1111/bdi.12149. Link to article on publisher's site
DOI
10.1111/bdi.12149Permanent Link to this Item
http://hdl.handle.net/20.500.14038/51012PubMed ID
24262071Related Resources
ae974a485f413a2113503eed53cd6c53
10.1111/bdi.12149