UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Date
3-1-2012
Document Type
Article
Subjects
Liver Diseases, Alcoholic; Oxidative Stress; Inflammation
Disciplines
Digestive System Diseases | Gastroenterology | Hepatology
Abstract
Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production and cellular stress due to oxidative processes, contributing to the development and progression of disease. While oxidative stress and inflammatory responses are studied independently in ALD, mechanisms linking these two processes play a major role in pathogenesis of disease. Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease.
Related Resources
PubMed ID
22500241
Comments
Citation: Int J Hepatol. 2012;2012:853175. Link to article on publisher's site
Copyright © 2012 Aditya Ambade and Pranoti Mandrekar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.