Angiogenic factors for the prediction of preeclampsia in high-risk women
Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Obstetrics and Gynecology
Adult; Angiogenesis Inducing Agents; Biological Markers; Female; Humans; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Pregnancy Proteins; Pregnancy, High-Risk; Prospective Studies; Vascular Endothelial Growth Factor Receptor-1
Life Sciences | Medicine and Health Sciences | Obstetrics and Gynecology
OBJECTIVE: The objective of the study was to evaluate angiogenic factors for the prediction of preeclampsia in high-risk women.
STUDY DESIGN: We collected serial serum specimens from 94 women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) were measured by enzyme-linked immunosorbent assay.
RESULTS: Mean serum sFlt1 and the sFlt1/PlGF ratio were higher in subjects who developed early-onset (less than 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks gestation onward. In subjects who developed late-onset (34 weeks or later) preeclampsia, sFlt1 was significantly increased after 31 weeks' gestation. The sFlt1/PlGF ratio at 22-26 weeks was highly predictive of early-onset preeclampsia. The within-woman rate of change of the sFlt1/PlGF ratio was predictive of overall preeclampsia risk.
CONCLUSIONS: In high-risk women, serum sFlt1 and the sFlt1:PlGF ratio are altered prior to preeclampsia onset and may be predictive of preeclampsia. Larger studies are needed to confirm these findings.
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Citation: Am J Obstet Gynecol. 2007 Sep;197(3):244.e1-8. Link to article on publisher's site