Title

Lipid changes during the menopause transition in relation to age and weight: the Study of Women's Health Across the Nation

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Date

6-1-2009

Document Type

Article

Subjects

Adult; Age Factors; *Body Weight; Estradiol; Female; Follicle Stimulating Hormone; Humans; Linear Models; Lipids; Longitudinal Studies; Menopause; Middle Aged; Prospective Studies; United States

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

Few studies have prospectively examined lipid changes across the menopause transition or in relation to menopausal changes in endogenous hormones. The relative independent contributions of menopause and age to lipid changes are unclear. Lipid changes were examined in relation to changes in menopausal status and in levels of estradiol and follicle-stimulating hormone in 2,659 women followed in the Study of Women's Health Across the Nation (1995-2004). Baseline age was 42-52 years, and all were initially pre- or perimenopausal. Women were followed annually for up to 7 years (average, 3.9 years). Lipid changes occurred primarily during the later phases of menopause, with menopause-related changes similar in magnitude to changes attributable to aging. Total cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a) peaked during late peri- and early postmenopause, while changes in the early stages of menopause were minimal. The relative odds of low density lipoprotein cholesterol (> or =130 mg/dL) for early postmenopausal, compared with premenopausal, women were 2.1 (95% confidence interval: 1.5, 2.9). High density lipoprotein cholesterol also peaked in late peri- and early postmenopause. Results for estradiol and follicle-stimulating hormone confirmed the results based on status defined by bleeding patterns. Increases in lipids were smallest in women who were heaviest at baseline.

Rights and Permissions

Citation: Am J Epidemiol. 2009 Jun 1;169(11):1352-61. Epub 2009 Apr 8. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

19357323