"Persistence" improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years
Department of Medicine, Division of Preventive and Behavioral Medicine
Life Sciences | Medicine and Health Sciences | Women's Studies
OBJECTIVE: The ReSTAGE collaboration evaluated four menstrual markers of entry to late-stage menopausal transition. The aim of this study was to assess the additional usefulness of "persistence" in relation to a clinically accessible menstrual marker of late menopausal transition, taking age into account.
METHODS: In this study, a secondary analysis of menstrual calendar data in two ReSTAGE-collaborating studies with comparatively low age at beginning of menstrual calendar observation was performed.
RESULTS: Sixty days of amenorrhea is as useful for predicting time to the final menstrual period as the currently accepted 90-day marker for women older than 45 years. For those aged between 40 and 44 years, recurrence of the 60-day marker within the next 10 cycles is a better indicator than a single occurrence of the 60-day marker or the 90-day marker.
CONCLUSIONS: Sixty-day amenorrhea is as reliable a marker of late menopausal transition as the traditional 90-day marker for women older than 45 years. For those aged 40 to 44 years, keeping menstrual records to check for a recurrence of the 60-day marker will be useful.
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Citation: Menopause. 2010 Jan-Feb;17(1):191-3. Link to article on publisher's site
Taffe, John R.; Cain, Kevin C.; Mitchell, Ellen S.; Woods, Nancy F.; Crawford, Sybil L.; and Harlow, Sioban D., ""Persistence" improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years" (2010). Women’s Health Research Faculty Publications. 451.