Title

Membrane cytoskeleton: PIP(2) pulls the strings

UMMS Affiliation

Department of Cell Biology

Date

5-10-2000

Document Type

Article

Subjects

Animals; Calcium; Cell Membrane; Cytoskeleton; Humans; Isoenzymes; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C; Phospholipase C gamma; Phosphoric Monoester Hydrolases

Disciplines

Cell Biology | Life Sciences | Medicine and Health Sciences

Abstract

A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.

Rights and Permissions

Citation: Curr Biol. 2000 May 4;10(9):R351-4.

Related Resources

Link to article in PubMed

PubMed ID

10801429