Title
Membrane cytoskeleton: PIP(2) pulls the strings
UMMS Affiliation
Department of Cell Biology
Date
5-10-2000
Document Type
Article
Subjects
Animals; Calcium; Cell Membrane; Cytoskeleton; Humans; Isoenzymes; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C; Phospholipase C gamma; Phosphoric Monoester Hydrolases
Disciplines
Cell Biology | Life Sciences | Medicine and Health Sciences
Abstract
A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.
Rights and Permissions
Citation: Curr Biol. 2000 May 4;10(9):R351-4.
Related Resources
PubMed ID
10801429
COinS
