Copy choice mechanism of immunoglobulin heavy-chain switch recombination
Department of Molecular Genetics and Microbiology
Animals; Base Sequence; Cloning, Molecular; DNA; *Gene Rearrangement, B-Lymphocyte, Heavy Chain; *Genes, Immunoglobulin; *Genes, Regulator; *Genes, Switch; Immunoglobulin Heavy Chains; Mice; Molecular Sequence Data; *Recombination, Genetic; Restriction Mapping
Life Sciences | Medicine and Health Sciences | Women's Studies
The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.
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Citation: Mol Cell Biol. 1990 Jan;10(1):397-400.