Title

Copy choice mechanism of immunoglobulin heavy-chain switch recombination

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

1-1990

Document Type

Article

Subjects

Animals; Base Sequence; Cloning, Molecular; DNA; *Gene Rearrangement, B-Lymphocyte, Heavy Chain; *Genes, Immunoglobulin; *Genes, Regulator; *Genes, Switch; Immunoglobulin Heavy Chains; Mice; Molecular Sequence Data; *Recombination, Genetic; Restriction Mapping

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.

Rights and Permissions

Citation: Mol Cell Biol. 1990 Jan;10(1):397-400.

Related Resources

Link to article in PubMed

PubMed ID

2104661