Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes
Department of Molecular Genetics and Microbiology
Animals; Base Sequence; Cell Line; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; *Genes, Immunoglobulin; Immunoglobulin Heavy Chains; Immunoglobulin alpha-Chains; Mice; Molecular Sequence Data; Polyribosomes; RNA, Messenger; Restriction Mapping
Life Sciences | Medicine and Health Sciences | Women's Studies
We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha heavy-chain genes in immunoglobulin M-expressing cells of the I.29 mu B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line alpha RNA has a small open reading frame that does not include the C alpha domain, and this RNA appears to be present on polysomes in I.29 mu cells.
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Citation: Mol Cell Biol. 1990 Jan;10(1):382-6.