Immunoglobulin class switching
Department of Molecular Genetics and Microbiology
Animals; *Immunoglobulin Class Switching; Immunoglobulins
Life Sciences | Medicine and Health Sciences | Women's Studies
Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.
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Citation: Curr Opin Immunol. 1996 Apr;8(2):199-205.