Title

Immunoglobulin class switching

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

4-1996

Document Type

Article

Subjects

Animals; *Immunoglobulin Class Switching; Immunoglobulins

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to which a B cell is switched is regulated by cytokines and B-cell activators at the level of transcription of unrearranged heavy chain constant genes. Gene-targeting experiments in mice have proved the essential role of these transcripts in switch recombination. Their possible functions are discussed in the context of a model for the mechanisms of class switching.

Rights and Permissions

Citation: Curr Opin Immunol. 1996 Apr;8(2):199-205.

Related Resources

Link to article in PubMed

PubMed ID

8725943