Title

Immunology. A touch of antibody class

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

5-12-2000

Document Type

Article

Subjects

Animals; B-Lymphocytes; Cytokines; DNA; Genes, Immunoglobulin; *Immunoglobulin Class Switching; Immunoglobulin Heavy Chains; *Immunoglobulin Switch Region; Mice; Mice, Transgenic; Models, Genetic; *Nucleic Acid Hybridization; RNA; RNA Splicing; Recombination, Genetic; Ribonuclease H, Calf Thymus; Templates, Genetic; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

When B cells, the antibody producing cells of the body, encounter antigen they switch from producing immunoglobulin (Ig) M to producing other classes of antibody (IgG, IgA or IgE), the class selected depending on the type of immune response needed. But the way in which B cells skillfully switch from one antibody class to another is still not clear although it is known to involve recombination between genes. In a Perspective, Stavnezer explains how formation of hybrids between RNA transcripts (transcribed from the heavy chain gene to which the cell will switch) and the DNA template at crucial switch sequences in the genome regulates class switching (Tracy et al.). It is possible that an as yet unidentified endonuclease digests the hybrid thereby creating the DNA ends that will be joined together.

Rights and Permissions

Citation: Science. 2000 May 12;288(5468):984-5. Link to article on publisher's site

Related Resources

Link to article in PubMed

PubMed ID

10841719