Does activation-induced deaminase initiate antibody diversification by DNA deamination
Department of Molecular Genetics and Microbiology
Antibody Diversity; B-Lymphocytes; Cytidine Deaminase; *Gene Conversion; *Genes, Immunoglobulin; Humans; Immunoglobulin M; Immunoglobulin Variable Region
Life Sciences | Medicine and Health Sciences | Women's Studies
Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region segments, three processes that diversify antibodies during immune responses. Although AID has homology to RNA-editing enzymes, three recent reports suggest it could initiate the diversification processes by deaminating cytidine residues within the antibody genes themselves.
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Citation: Trends Genet. 2002 Nov;18(11):541-3.