Title
Immunoglobulin genes: generating diversity with AID and UNG
UMMS Affiliation
Department of Molecular Genetics and Microbiology
Date
10-29-2002
Document Type
Article
Subjects
Animals; Cytidine Deaminase; *DNA Glycosylases; *Genes, Immunoglobulin; Mice; N-Glycosyl Hydrolases; Uracil-DNA Glycosidase
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
Rights and Permissions
Citation: Curr Biol. 2002 Oct 29;12(21):R725-7.
Related Resources
PubMed ID
12419200
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