Title

Immunoglobulin genes: generating diversity with AID and UNG

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

10-29-2002

Document Type

Article

Subjects

Animals; Cytidine Deaminase; *DNA Glycosylases; *Genes, Immunoglobulin; Mice; N-Glycosyl Hydrolases; Uracil-DNA Glycosidase

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

Rights and Permissions

Citation: Curr Biol. 2002 Oct 29;12(21):R725-7.

Related Resources

Link to article in PubMed

PubMed ID

12419200