Title

Antibody class switching: uncoupling S region accessibility from transcription

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

7-21-2004

Document Type

Article

Subjects

Acetylation; Animals; Cytidine Deaminase; Histones; Humans; Immunoglobulin Class Switching; Immunoglobulin Switch Region; RNA Polymerase II; Transcription, Genetic

Disciplines

Genetics and Genomics | Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently, Nambu et al. showed that histone acetylation is induced at switch (S) regions undergoing CSR; however, histone acetylation without accompanying S region transcription is insufficient to attract activation-induced cytidine deaminase (AID), which is required for CSR. They also show that AID can associate with RNA polymerase II. These results support the model that germline transcripts are required to form single-stranded DNA, the AID substrate and further suggest that AID is recruited to S regions by the transcriptional machinery.

Rights and Permissions

Citation: Trends Genet. 2004 Aug;20(8):337-40. Link to article on publisher's site

Related Resources

Link to article in PubMed

PubMed ID

15262403