Title

Evolution of isotype switching

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

8-2004

Document Type

Article

Subjects

Animals; Cytidine Deaminase; *Evolution, Molecular; *Gene Rearrangement; Humans; *Immunoglobulin Class Switching; Immunoglobulins; Mice; Variation (Genetics); Vertebrates

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

This review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes from fishes to mammals. Importantly, activation-induced cytidine deaminase (AID), which is essential for CSR and somatic hypermutation, is found in fishes. Although at least some fishes are likely to undergo SHM, CSR is highly unlikely to occur in this group. We discuss the first appearance of CSR in amphibians and how it differs in birds and mammals.

Rights and Permissions

Citation: Semin Immunol. 2004 Aug;16(4):257-75. Link to article on publisher's site

Related Resources

Link to article in PubMed

PubMed ID

15522624