Title

Effects on metastases of drug therapy during developing and established tumor immunity

UMMS Affiliation

Department of Medicine, Division of Hematology/Oncology

Date

12-15-1983

Document Type

Article

Subjects

Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Immunity, Natural; Immunosuppression; Lung Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; *Transplantation Immunology

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

The effectiveness of treatment with cyclophosphamide, methotrexate and 5-fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5-fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with established tumor immunity gave added benefit without detectable depression of immune resistance.

Rights and Permissions

Citation: Int J Cancer. 1983 Dec 15;32(6):759-63.

Related Resources

Link to article in PubMed

PubMed ID

6654527