Title
Effects on metastases of drug therapy during developing and established tumor immunity
UMMS Affiliation
Department of Medicine, Division of Hematology/Oncology
Date
12-15-1983
Document Type
Article
Subjects
Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Immunity, Natural; Immunosuppression; Lung Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; *Transplantation Immunology
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
The effectiveness of treatment with cyclophosphamide, methotrexate and 5-fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5-fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with established tumor immunity gave added benefit without detectable depression of immune resistance.
Rights and Permissions
Citation: Int J Cancer. 1983 Dec 15;32(6):759-63.
Related Resources
PubMed ID
6654527
