Effects on metastases of drug therapy during developing and established tumor immunity

UMMS Affiliation

Department of Medicine, Division of Hematology/Oncology



Document Type



Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Immunity, Natural; Immunosuppression; Lung Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; *Transplantation Immunology


Life Sciences | Medicine and Health Sciences | Women's Studies


The effectiveness of treatment with cyclophosphamide, methotrexate and 5-fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5-fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with established tumor immunity gave added benefit without detectable depression of immune resistance.

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Citation: Int J Cancer. 1983 Dec 15;32(6):759-63.

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