Title

5-Fluorouracil-associated cardiotoxicity

UMMS Affiliation

Department of Medicine, Division of Hematology/Oncology

Date

1-1-1988

Document Type

Article

Subjects

Electrocardiography; Fluorouracil; Heart; Humans; Male; Middle Aged

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.

Rights and Permissions

Citation: Cancer. 1988 Jan 1;61(1):36-45.

Related Resources

Link to article in PubMed

PubMed ID

3275485