A feasibility study of intensive CAF as outpatient adjuvant therapy for stage II breast cancer in a cooperative group: CALGB 8443
Department of Medicine, Division of Hematology/Oncology
Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; effects; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Injections, Intravenous; Middle Aged; Outpatients; Patient Compliance; Pilot Projects
Life Sciences | Medicine and Health Sciences | Women's Studies
In preparation for a national Phase III study of dose and dose intensity in the treatment of node-positive, Stage II adenocarcinoma of the female breast, CALGB instituted a pilot study of intensive intravenous outpatient CAF (cyclophosphamide, Adriamycin, 5-fluorouracil) for four months. This study was designed to give full doses of drugs without dose reduction for hematologic toxicity. In order to evaluate the feasibility of physician and patient compliance with a potentially toxic therapy, a multi-institution pilot study was performed. This protocol demonstrated that a cooperative group could deliver toxic drug doses to outpatients with a median of 98% of cyclophosphamide, 97% of Adriamycin (doxorubicin), and 91% of 5-fluorouracil administered on schedule. Major side effects, as expected, were leukopenia, nausea, and vomiting. Disease-free survival is at least equivalent to that observed in previous studies.
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Citation: Cancer Invest. 1990;8(6):571-5.
Budman, Daniel R.; Korzun, Ann Hughes; Aisner, Joseph; Younger, Jerry; Silver, Richard; Costanza, Mary E.; Rice, Mary Alice; and Wood, William, "A feasibility study of intensive CAF as outpatient adjuvant therapy for stage II breast cancer in a cooperative group: CALGB 8443" (1990). Women’s Health Research Faculty Publications. Paper 106.
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