Title

A feasibility study of intensive CAF as outpatient adjuvant therapy for stage II breast cancer in a cooperative group: CALGB 8443

UMMS Affiliation

Department of Medicine, Division of Hematology/Oncology

Date

1-1-1990

Document Type

Article

Subjects

Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; effects; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Injections, Intravenous; Middle Aged; Outpatients; Patient Compliance; Pilot Projects

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

In preparation for a national Phase III study of dose and dose intensity in the treatment of node-positive, Stage II adenocarcinoma of the female breast, CALGB instituted a pilot study of intensive intravenous outpatient CAF (cyclophosphamide, Adriamycin, 5-fluorouracil) for four months. This study was designed to give full doses of drugs without dose reduction for hematologic toxicity. In order to evaluate the feasibility of physician and patient compliance with a potentially toxic therapy, a multi-institution pilot study was performed. This protocol demonstrated that a cooperative group could deliver toxic drug doses to outpatients with a median of 98% of cyclophosphamide, 97% of Adriamycin (doxorubicin), and 91% of 5-fluorouracil administered on schedule. Major side effects, as expected, were leukopenia, nausea, and vomiting. Disease-free survival is at least equivalent to that observed in previous studies.

Rights and Permissions

Citation: Cancer Invest. 1990;8(6):571-5.

Related Resources

Link to article in PubMed

PubMed ID

2292049

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