The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partner, UMass Memorial Health Care. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. The goals of the UMCCTS are to 1) To accelerate the translation of basic discoveries into practical, cost effective solutions that improve human health; and 2) To develop and support the next generation of leaders in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2011

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Alcohol Screening and Risk of Postoperative Complications in Male VA Patients Undergoing Major Non-cardiac Surgery, Katharine A. Bradley, Anna D. Rubinsky, Haili Sun, Chris L. Bryson, Michael J. Bishop, David K. Blough, William G. Henderson, Charles Maynard, Mary T. Hawn, Hanne Tonnesen, Grant Hughes, Lauren A. Beste, Alex H.S. Harris, Eric J. Hawkins, Thomas K. Houston, and Daniel R. Kivlahan

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What Should We Include in a Cultural Competence Curriculum? An Emerging Formative Evaluation Process to Foster Curriculum Development, Katie Crenshaw, Richard M. Shewchuk, Haiyan Qu, Lisa J. Stanton, Judy Ann Bigby, Thomas K. Houston, Jeroan J. Allison, and Carlos A. Estrada

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Assessment of differential item functioning in the experiences of discrimination index: the Coronary Artery Risk Development in Young Adults (CARDIA) Study, Timothy J. Cunningham, Lisa F. Berkman, Steven L. Gortmaker, Catarina I. Kiefe, David R. Jacobs Jr., Teresa E. Seeman, and Ichiro Kawachi

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A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C, Jules L. Dienstag, Marc G. Ghany, Timothy R. Morgan, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Hae-Young Kim, Leonard B. Seeff, Gyongyi Szabo, Elizabeth C. Wright, Richard K. Sterling, Gregory T. Everson, Karen L. Lindsay, William M. Lee, Anna S. F. Lok, Chihiro Morishima, Anne M. Stoddard, and James E. Everhart

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A new look at quantifying tobacco exposure during pregnancy using fuzzy clustering, Hua Fang, Craig Johnson, Christian Stopp, and Kimberly Andrews Espy

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Physician and Patient Influences on Provider Performance: {beta}-Blockers in Post-Myocardial Infarction Management in the MI-Plus Study, Ellen M. Funkhouser, Thomas K. Houston, Deborah A. Levine, Joshua S. Richman, Jeroan J. Allison, and Catarina I. Kiefe

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Recruitment activities for a nationwide, population-based, group-randomized trial: the VA MI-Plus study, Ellen M. Funkhouser, Deborah A. Levine, Joe K. Gerald, Thomas K. Houston, Nancy K. Johnson, Jeroan J. Allison, and Catarina I. Kiefe

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Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults, Jian Gong, Hannia Campos, Stephen T. McGarvey, Zhijin Wu, Robert J. Goldberg, and Ana Baylin

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Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine, Jian Gong, Hannia Campos, Stephen McGarvey, Zhijin Wu, Robert J. Goldberg, and Ana Baylin

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Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity, Olga T. Hardy, Richard A. Perugini, Sarah M. Nicoloro, Karen A. Gallagher-Dorval, Vishwajeet Puri, Juerg R. Straubhaar, and Michael P. Czech

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Social isolation, C-reactive protein, and coronary heart disease mortality among community-dwelling adults, Kathi L. Heffner, Molly E. Waring, Mary B. Roberts, Charles B. Eaton, and Robert Gramling

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Geographic and demographic variability in 20-year hypertension incidence: the CARDIA study, Deborah A. Levine, Cora E. Lewis, O. Dale Williams, Monika M. Safford, Kiang Liu, David A. Calhoun, Yongin Kim, David R. Jacobs Jr., and Catarina I. Kiefe

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Racial/ethnic disparities in access to physician care and medications among US stroke survivors, Deborah A. Levine, M. V. Neidecker, Catarina I. Kiefe, S. Karve, L. S. Williams, and Jeroan J. Allison

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Racial variation in willingness to trade financial resources for life-prolonging cancer treatment, Michelle Y. Martin, Maria Pisu, Robert A. Oster, Julie M. Urmie, Deborah Schrag, Haiden A. Huskamp, Jeannette Lee, Catarina I. Kiefe, and Mona N. Fouad

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Activating peripheral arterial disease patients to reduce cholesterol: a randomized trial, Mary McGrae McDermott, George W. Reed, Philip Greenland, Kathleen M. Mazor, Sherry L. Pagoto, Judith K. Ockene, Rex Graff, Philip A. Merriam, Katherine Leung, Larry Manheim, Melina R. Kibbe, Barbara C. Olendzki, William H. Pearce, and Ira S. Ockene

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30-year trends in heart failure in patients hospitalized with acute myocardial infarction, David D. McManus, Marcello Chinali, Jane S. Saczynski, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, Darleen M. Lessard, and Robert J. Goldberg

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Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI, David D. McManus, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, Darleen M. Lessard, and Robert J. Goldberg

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Thirty-year (1975 to 2005) trends in the incidence rates, clinical features, treatment practices, and short-term outcomes of patients [less than] 55 years of age hospitalized with an initial acute myocardial infarction, David D. McManus, Stephen M. Piacentine, Darleen M. Lessard, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, and Robert J. Goldberg

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Socioeconomic status and polycystic ovary syndrome, Sharon Stein Merkin, Ricardo Azziz, Teresa E. Seeman, Ronit Calderon-Margalit, Martha L. Daviglus, Catarina I. Kiefe, Karen A. Matthews, Barbara Sternfeld, and David S. Siscovick

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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian

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Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction, Hoa L. Nguyen, Jane S. Saczynski, Joel M. Gore, Molly E. Waring, Darleen M. Lessard, Jorge L. Yarzebski, George W. Reed, Frederick A. Spencer, Shu-Xia Li, and Robert J. Goldberg

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Venous thromboembolism in patients with reduced estimated GFR: a population-based perspective, Amisha M. Parikh, Frederick A. Spencer, Darleen M. Lessard, Catherine Emery, Ana Baylin, Crystal Linkletter, and Robert J. Goldberg

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Cognitive Mapping Tobacco Control Advice for Dentistry: A Dental PBRN Study, Haiyan Qu, Thomas K. Houston, Jessica H. Williams, Gregg H. Gilbert, and Richard M. Shewchuk

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Electronic health records in small physician practices: availability, use, and perceived benefits, Sowmya R. Rao, Catherine M. DesRoches, Karen Donelan, Eric G. Campbell, Paola D. Miralles, and Ashish K. Jha

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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Professional values and reported behaviours of doctors in the USA and UK: quantitative survey, Martin Roland, Sowmya R. Rao, Bonnie Sibbald, Mark Hann, Stephen Harrison, Alex Walter, Bruce Guthrie, Catherine M. DesRoches, Timothy G. Ferris, and Eric G. Campbell

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Randomized trial of a literacy-sensitive, culturally tailored diabetes self-management intervention for low-income latinos: latinos en control, Milagros C. Rosal, Ira S. Ockene, Angela Restrepo, Mary Jo White, Amy Borg, Barbara C. Olendzki, Jeffrey Scavron, Lucy M. Candib, Garry Welch, and George W. Reed

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Development of an interactive, Web-delivered system to increase provider-patient engagement in smoking cessation, Rajani S. Sadasivam, Kathryn Delaughter, Katie Crenshaw, Heather J. Sobko, Jessica H. Williams, Heather L. Coley, Midge N. Ray, Daniel E. Ford, Jeroan J. Allison, and Thomas K. Houston

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Patient complexity and diabetes quality of care in rural settings, Amanda H. Salanitro, Monika M. Safford, Thomas K. Houston, Jessica H. Williams, Fernando Ovalle, Pamela Payne-Foster, Jeroan J. Allison, and Carlos A. Estrada

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Temporal Trends in Presentation for Outpatient HIV Medical Care 2000-2010: Implications for Short-term Mortality, Paula S. Seal, David A. Jackson, Eric Chamot, James H. Willig, Christa R. Nevin, Jeroan J. Allison, James L. Raper, Mirjam Kempf, Joseph E. Schumacher, Michael S. Saag, and Michael J. Mugavero

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Weight and mortality following heart failure hospitalization among diabetic patients, Molly E. Waring, Jane S. Saczynski, David D. McManus, Michael Zacharias, Darleen M. Lessard, Joel M. Gore, and Robert J. Goldberg

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Six-month mortality and cardiac catheterization in non-ST-segment elevation myocardial infarction patients with anemia, Wen-Chih Wu, Molly E. Waring, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore, and Robert J. Goldberg

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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains, Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore

Publications from 2008

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Gene therapy for cystic fibrosis, Christian Mueller and Terence R. Flotte