Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge
Authors
Riley, Margaret A.Robinson, Sandra M.
Roy, Christopher M.
Dennis, Morgan
Liu, Vivian
Dorit, Robert L.
Document Type
Journal ArticlePublication Date
2012-12-01Keywords
AnimalsAnti-Bacterial Agents
Bacteriuria
Colicins
Drug Resistance, Bacterial
Escherichia coli
Escherichia coli Infections
Humans
Microbial Sensitivity Tests
UMCCTS funding
Amino Acids, Peptides, and Proteins
Biochemistry, Biophysics, and Structural Biology
Microbiology
Therapeutics
Metadata
Show full item recordAbstract
Pathogenic bacteria resistant to many or all antibiotics already exist. With the decline in microbiological research at pharmaceutical companies, the high rate at which resistance has evolved and spread has demanded a novel approach to addressing this critical human health issue. In the present paper, we propose a new paradigm in antibiotic discovery and development, one that applies ecological and evolutionary theory to design antimicrobial drugs that are more difficult and/or more costly to resist. In essence, we propose to simply adopt the strategies invented and applied by bacteria for hundreds of millions of years. Our research focuses on bacteriocins, powerful biological weapons, and their use as alternative therapeutics in human health.Source
Biochem Soc Trans. 2012 Dec 1;40(6):1438-42. doi: 10.1042/BST20120179.DOI
10.1042/BST20120179.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50302PubMed ID
23176495Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1042/BST20120179.