MIFuzzy Clustering for Incomplete Longitudinal Data in Smart Health

UMMS Affiliation

Department of Quantitative Health Sciences



Document Type



Computer Sciences | Telemedicine | Translational Medical Research


Missing data are common in longitudinal observational and randomized controlled trials in smart health studies. Multiple-imputation based fuzzy clustering is an emerging non-parametric soft computing method, used for either semi-supervised or unsupervised learning. Multiple imputation (MI) has been widely-used in missing data analyses, but has not yet been scrutinized for unsupervised learning methods, although they are important for explaining the heterogeneity of treatment effects. Built upon our previous work on MIfuzzy clustering, this paper introduces the MIFuzzy concepts and performance, theoretically, empirically and numerically demonstrate how MI-based approach can reduce the uncertainty of clustering accuracy in comparison to non- and single-imputation based clustering approach. This paper advances our understanding of the utility and strength of MIFuzzy clustering approach to processing incomplete longitudinal behavioral intervention data.

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Citation: Smart Health (Amst). 2017 Jun;1-2:50-65. doi: 10.1016/j.smhl.2017.04.002. Epub 2017 Apr 27. Link to article on publisher's site

Related Resources

Link to Article in PubMed


UMCCTS funding, longitudinal data, Missing values, Fuzzy clustering, Multiple imputation, MIFuzzy

PubMed ID