Weight and mortality following heart failure hospitalization among diabetic patients
Department of Medicine, Division of Geriatric Medicine; Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Internal Medicine; Department of Quantitative Health Sciences; Meyers Primary Care Institute
Medical Subject Headings
Acute Disease; Aged; Aged, 80 and over; *Body Weight; Cause of Death; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Heart Failure; Hospitalization; Humans; Male; Massachusetts; Middle Aged; Obesity; Odds Ratio; Overweight; Prognosis; Proportional Hazards Models; Risk Factors; Survival Analysis; Thinness
Cardiovascular Diseases | Endocrine System Diseases | Nutritional and Metabolic Diseases
BACKGROUND: Type 2 diabetes is an important risk factor for heart failure and is common among patients with heart failure. The impact of weight on prognosis after hospitalization for acute heart failure among patients with diabetes is unknown. The objective of this study was to examine all-cause mortality in relation to weight status among patients with type 2 diabetes hospitalized for decompensated heart failure.
METHODS: The Worcester Heart Failure Study included adults admitted with acute heart failure to all metropolitan Worcester medical centers in 1995 and 2000. The weight status of 1644 patients with diabetes (history of type 2 diabetes in medical record or admission serum glucose >/=200 mg/dL) was categorized using body mass index calculated from height and weight at admission. Survival status was ascertained at 1 and 5 years after hospital admission. RESULTS: Sixty-five percent of patients were overweight or obese and 3% were underweight. Underweight patients had 50% higher odds of all-cause mortality within 5 years of hospitalization for acute heart failure than normal weight patients. Class I and II obesity were associated with 20% and 40% lower odds of dying. Overweight and Class III obesity were not associated with mortality. Results were similar for mortality within 1 year of hospitalization for acute heart failure.
CONCLUSIONS: The mechanisms underlying the association between weight status and mortality are not fully understood. Additional research is needed to explore the effects of body composition, recent weight changes, and prognosis after hospitalization for heart failure among patients with diabetes.
Waring, Molly E.; Saczynski, Jane S.; McManus, David D.; Zacharias, Michael; Lessard, Darleen M.; Gore, Joel M.; and Goldberg, Robert J., "Weight and mortality following heart failure hospitalization among diabetic patients" (2011). UMass Center for Clinical and Translational Science Supported Publications. 11.