The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partner, UMass Memorial Health Care. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. The goals of the UMCCTS are to 1) To accelerate the translation of basic discoveries into practical, cost effective solutions that improve human health; and 2) To develop and support the next generation of leaders in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2017

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Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study, Peter R. Chai, Stephanie Carreiro, Brendan J. Innes, Rochelle K. Rosen, Conall O'Cleirigh, Kenneth Mayer, and Edward W. Boyer

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Meta-Analysis of Odds Ratios: Current Good Practices, Bei-Hung Chang and David C. Hoaglin

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Hospice Use and Pain Management in Elderly Nursing Home Residents With Cancer, Jacob N. Hunnicutt, Jennifer Tjia, and Kate L. Lapane

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Comparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis, Alok Kapoor, A. Ellis, N. Shaffer, Jerry H. Gurwitz, A. Chandramohan, J. Saulino, A. Ishak, T. Okubanjo, F. Michota, Elaine M. Hylek, and T. A. Trikalinos

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Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year, Aimee Kroll-Desrosiers, Benjamin C. Nephew, Jessica A. Babb, Yurima Guilarte-Walker, Tiffany A. Moore Simas, and Kristina M. Deligiannidis

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Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors, David D. McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J. Munson, Martin G. Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane Freedman, and Daniel Levy

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Attempted and Successful Vacuum-Assisted Vaginal Delivery by Prepregnancy Body Mass Index, Sebastian Ramos, Molly E. Waring, Katherine Leung, Nili S. Amir, Annika L. Bannon, and Tiffany A. Moore Simas

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A double-blind, placebo-controlled, phase-II clinical trial to evaluate oral simvastatin as a treatment for vitiligo, Stefan G. Vanderweil, Shinya U. Amano, Wei-Che Ko, Jillian M. Richmond, Michelle Kelley, Maryanne Makredes Senna, Andrea Pearson, Sandhya Chowdary, Celia Hartigan, Bruce A. Barton, and John E. Harris

Publications from 2016

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A Pilot Study of Deaf Trauma Survivors' Experiences: Early Traumas Unique to Being Deaf in a Hearing World, Melissa L. Anderson, Kelly S. Wolf Craig, Wyatte C. Hall, and Douglas M. Ziedonis

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Deaf People's Help-Seeking Following Trauma: Experiences With and Recommendations for the Massachusetts Behavioral Health Care System, Melissa L. Anderson, Kelly S. Wolf Craig, and Douglas M. Ziedonis

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Magnitude, treatment, and impact of diabetes mellitus in patients hospitalized with non-ST segment elevation myocardial infarction: A community-based study, Hamza H. Awad, Mayra Tisminetzky, Diana Metry, David D. McManus, Jorge L. Yarzebski, Joel Gore, and Robert J. Goldberg

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Infertility and Perinatal Loss: When the Bough Breaks, Amritha Bhat and Nancy Byatt

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HIV Stigma, Testing Attitudes and Health Care Access Among African-Born Men Living in the United States, Carol A. Bova, Chioma Nnaji, Augustus Woyah, and Akwasi Duah

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Smoking status and life expectancy after acute myocardial infarction in the elderly, Emily M. Bucholz, Adam L. Beckman, Catarina I. Kiefe, and Harlan M. Krumholz

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Change in Dietary Patterns and Change in Waist Circumference and DXA Trunk Fat Among Postmenopausal Women, Elizabeth M. Cespedes Feliciano, Lesley Tinker, JoAnn E. Manson, Matthew Allison, Thomas Rohan, Oleg Zaslavsky, Molly E. Waring, Keiko Asao, Lorena Garcia, Milagros C. Rosal, and Marian L. Neuhouser

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Job satisfaction of Department of Veterans Affairs peer mental health providers, Bei-Hung Chang, Lisa N. Mueller, Sandra G. Resnick, Katerine Osatuke, and Susan V. Eisen

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Peripartum neuroactive steroid and gamma-aminobutyric acid profiles in women at-risk for postpartum depression, Kristina M. Deligiannidis, Aimee R. Kroll-Desrosiers, Shunyan Mo, Hien P. Nguyen, Abby E. Svenson, Nina Jaitly, Janet E. Hall, Bruce A. Barton, Anthony J. Rothschild, and Scott A. Shaffer

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Cortisol response to the Trier Social Stress Test in pregnant women at risk for postpartum depression, Kristina M. Deligiannidis, Aimee R. Kroll-Desrosiers, Abby E. Svenson, Nina Jaitly, Bruce A. Barton, Janet E. Hall, and Anthony J. Rothschild

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A Pilot Health Information Technology-Based Effort to Increase the Quality of Transitions From Skilled Nursing Facility to Home: Compelling Evidence of High Rate of Adverse Outcomes, Jennifer L. Donovan, Abir O. Kanaan, Jerry H. Gurwitz, Jennifer Tjia, Sarah L. Cutrona, Lawrence D. Garber, Peggy Preusse, and Terry S. Field

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Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction, John D. Eicher, Yoshiyuki Wakabayashi, Olga Vitseva, Nada Esa, Yanqin Yang, Jun Zhu, Jane Freedman, David D. McManus, and Andrew D. Johnson

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The weight loss blogosphere: an online survey of weight loss bloggers, Martinus M. Evans, Pouran D. Faghri, Sherry L. Pagoto, Kristin L. Schneider, Molly E. Waring, Matthew C. Whited, Bradley M. Appelhans, Andrew Busch, and Ailton S. Coleman

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Pregnancy intentionality in relation to non-planning impulsivity, Prachi Godiwala, Bradley M. Appelhans, Tiffany A. Moore Simas, Rui Sherry Xiao, Kathryn E. Liziewski, Sherry L. Pagoto, and Molly E. Waring

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Decade-Long Trends (2001-2011) in the Incidence and Hospital Death Rates Associated with the In-Hospital Development of Cardiogenic Shock after Acute Myocardial Infarction, Robert J. Goldberg, Raghavendra Charan P. Makam, Jorge L. Yarzebski, David D. McManus, Darleen M. Lessard, and Joel M. Gore

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Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study), Eun-Jeong Kim, Xiaoyan Yin, Joao D. Fontes, Jared W. Magnani, Steven A. Lubitz, David D. McManus, Sudha Seshadri, Ramachandran S. Vasan, Patrick T. Ellinor, Martin G. Larson, Emelia J. Benjamin, and Michael Rienstra

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Relation of Atrial Fibrillation in Acute Myocardial Infarction to In-Hospital Complications and Early Hospital Readmission, Amartya Kundu, Kevin O'Day, Amir Y. Shaikh, Darleen M. Lessard, Jane S. Saczynski, Jorge L. Yarzebski, Chad E. Darling, Ramses Thabet, Mohammed W. Akhter, Kevin C. Floyd, Robert J. Goldberg, and David D. McManus

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Racial Differences in the Performance of Existing Risk Prediction Models for Incident Type 2 Diabetes: The CARDIA Study, Mary E. Lacy, Gregory A. Wellenius, Mercedes R. Carnethon, Eric B. Loucks, April P. Carson, Xi Luo, Catarina I. Kiefe, Annie Gjelsvik, Erica P. Gunderson, Charles B. Eaton, and Wen-Chih Wu

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PULSE-SMART: Pulse-Based Arrhythmia Discrimination Using a Novel Smartphone Application, David D. McManus, Jo Woon Chong, Apurv Soni, Jane S. Saczynski, Nada Esa, Craig Napolitano, Chad E. Darling, Edward W. Boyer, Rochelle Rosen, Kevin C. Floyd, and Ki H. Chon

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Reliability of Predicting Early Hospital Readmission After Discharge for an Acute Coronary Syndrome Using Claims-Based Data, David D. McManus, Jane S. Saczynski, Darleen M. Lessard, Molly E. Waring, Jeroan J. Allison, David C. Parish, Robert J. Goldberg, Arlene S. Ash, and Catarina I. Kiefe

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Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis, Ann M. Moormann and Jeffrey A. Bailey

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Obesity/Overweight and the Role of Working Conditions: A Qualitative, Participatory Investigation, Suzanne Nobrega, Nicole J. Champagne, Marlene Abreu, Marcy Goldstein-Gelb, Mirna Montano, Isabel Lopez, Jonny Arevalo, Suezanne Bruce, and Laura Punnett

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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium, Faye L. Norby and David D. McManus

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Reproductive Risk Factors and Coronary Heart Disease in the Women's Health Initiative Observational Study, Nisha I. Parikh and Molly E. Waring

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Patterns of Adult Cross-Racial Friendships: A Context for Understanding Contemporary Race Relations, Deborah L. Plummer, Rosalie A. Torres Stone, Lauren R. Powell, and Jeroan J. Allison

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Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study, Faisal Rahman, Na Wang, Xiaoyan Yin, Patrick T. Ellinor, Steven A. Lubitz, Paul A. LeLorier, David D. McManus, Lisa M. Sullivan, Sudha Seshadri, Ramachandran S. Vasan, Emelia J. Benjamin, and Jared W. Magnani

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Impact of a Collective Intelligence Tailored Messaging System on Smoking Cessation: The Perspect Randomized Experiment, Rajani S. Sadasivam, Erin M. Borglund, Roy Adams, Benjamin M. Marlin, and Thomas K. Houston

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Collective-Intelligence Recommender Systems: Advancing Computer Tailoring for Health Behavior Change Into the 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, and Thomas K. Houston

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Association of Left Atrial Function Index With Late Atrial Fibrillation Recurrence after Catheter Ablation, Mayank Sardana, Adedotun Ogunsua, Matthew Spring, Amir Y. Shaikh, Owusu Asamoah, Glenn Stokken, Clifford Browning, Cynthia Ennis, Kevin Donahue, Lawrence S. Rosenthal, Kevin C. Floyd, Gerard P. Aurigemma, Nisha I. Parikh, and David D. McManus

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Feasibility of Pairing Behavioral Activation With Exercise for Women With Type 2 Diabetes and Depression: The Get It Study Pilot Randomized Controlled Trial, Kristin L. Schneider, Emily Panza, Barbara Handschin, Yunsheng Ma, Andrew M. Busch, Molly E. Waring, Bradley M. Appelhans, Matthew C. Whited, Jacey Keeney, Daniel Kern, Mihaela Blendea, Ira S. Ockene, and Sherry L. Pagoto

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Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative, Aladdin H. Shadyab, Caroline A. Macera, Richard A. Shaffer, Sonia Jain, Linda C. Gallo, Margery Gass, Molly E. Waring, Marcia L. Stefanick, and Andrea Z. LaCroix

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Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources, Ravi Shah, Kahraman Tanriverdi, Daniel Levy, Martin Larson, Mark B. Gerstein, Eric O. Mick, Joel Rozowsky, Robert Kitchen, Venkatesh Murthy, Ekaterina Mikalev, and Jane E. Freedman

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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals, Upasna Sharma, Colin C. Conine, Jeremy Shea, Ana Boskovic, Alan G. Derr, Xin Y. Bing, Clemence Belleannee, Alper Kucukural, Ryan W. Serra, Fengyun Sun, Lina Song, Benjamin R. Carone, Emiliano P. Ricci, Xin Z. Li, Lucas Fauquier, Melissa J. Moore, Robert Sullivan, Craig C. Mello, Manuel Garber, and Oliver J. Rando

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It's All About Location, Location, Location: A New Perspective on Trauma Transport, Joshua J. Shaw, Charles M. Psoinos, and Heena P. Santry

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The presence of physician champions improved Kangaroo mother care in rural western India, Apurv Soni, Amee Amin, Dipen V. Patel, Nisha Fahey, Nikhil Shah, Ajay G. Phatak, Jeroan J. Allison, and Somashekhar M. Nimbalkar

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High Burden of Unrecognized Atrial Fibrillation in Rural India: An Innovative Community-Based Cross-Sectional Screening Program, Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael S. Chin, John Stephen Sullivan, Shyamsundar Raithatha, Robert J. Goldberg, Somashekhar Nimbalkar, Jeroan J. Allison, Sunil Thanvi, and David D. McManus

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Association of common mental disorder symptoms with health and healthcare factors among women in rural western India: results of a cross-sectional survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, and Somashekhar Nimbalkar

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ESammon: A computationaly enhanced sammon mapping based on data density, Chanpaul Jin Wang, Hua (Julia) Fang, and Honggang Wang

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Wireless Health, Honggang Wang, Md Shaad Mahmud, Hua (Julia) Fang, and Chonggang Wang

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Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative, Amal A. Wanigatunga, Sandrine S. Sourdet, Michael J. Lamonte, Molly E. Waring, Rami Nassir, Lorena Garcia, Jennifer W. Bea, Rebecca A. Seguin, Judith K. Ockene, Gloria E. Sarto, Marcia L. Stefanick, Marian C. Limacher, Todd Manini, and Women’s Health Initiative Investigators

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Prenatal Triptan Exposure and Internalising and Externalising Behaviour Problems in 3-Year-Old Children: Results from the Norwegian Mother and Child Cohort Study, Mollie E. Wood, Kate L. Lapane, Jean A. Frazier, Eivind Ystrom, Eric O. Mick, and Hedvig M.E. Nordeng

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Sleep Duration and Diet Quality Among Women Within 5 Years of Childbirth in the United States: A Cross-Sectional Study, Rui Sherry Xiao, Tiffany A. Moore Simas, Sherry L. Pagoto, Sharina D. Person, Milagros C. Rosal, and Molly E. Waring

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Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients, Michael Zacharias, Samuel Joffe, Elizabeth Konadu, Theo E. Meyer, MIchael S. Kiernan, Darleen M. Lessard, and Robert J. Goldberg

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A New MI-Based Visualization Aided Validation Index for Mining Big Longitudinal Web Trial Data, Zhaoyang Zhang, Hua (Julia) Fang, and Honggang Wang

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Multiple Imputation based Clustering Validation (MIV) for Big Longitudinal Trial Data with Missing Values in eHealth, Zhaoyang Zhang, Hua (Julia) Fang, and Honggang Wang

Publications from 2015

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Working Therapeutically With Deaf People Recovering From Trauma and Addiction, Melissa L. Anderson, Neil S. Glickman, Lisa Mistler, and Marco Gonzalez

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DNA-binding-domain fusions enhance the targeting range and precision of Cas9, Mehmet Fatih Bolukbasi, Ankit Gupta, Sarah Oikemus, Alan G. Derr, Manuel Garber, Michael H. Brodsky, Lihua Julie Zhu, and Scot A. Wolfe

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Exposure to selective serotonin reuptake inhibitors in late pregnancy increases the risk of persistent pulmonary hypertension of the newborn, but the absolute risk is low, Nancy Byatt and Marlene P. Freeman

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Enhancing Participation in Depression Care in Outpatient Perinatal Care Settings: A Systematic Review, Nancy Byatt, Len L. Levin, Douglas M. Ziedonis, Tiffany A. Moore Simas, and Jeroan J. Allison

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iMStrong: Deployment of a Biosensor System to Detect Cocaine Use, Stephanie Carreiro, Hua (Julia) Fang, Jianying Zhang, Kelley Wittbold, Shicheng Weng, Rachel Mullins, David A. Smelson, and Edward W. Boyer

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Decade-Long Trends in 30-Day Rehospitalization Rates After Acute Myocardial Infarction, Han-Yang Chen, Mayra Tisminetzky, Kate L. Lapane, Jorge L. Yarzebski, Sharina D. Person, Catarina I. Kiefe, Joel Gore, and Robert J. Goldberg

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Narratives to enhance smoking cessation interventions among African-American smokers, the ACCE project, Andrea Cherrington, Jessica H. Williams, Pamela Payne Foster, Heather L. Coley, Connie Kohler, Jeroan J. Allison, Catarina I. Kiefe, Julie E. Volkman, and Thomas K. Houston

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Smoking Topography in Korean American and White Men: Preliminary Findings, Sangkeun Chung, Sun S. Kim, Nisha Kini, Hua (Julia) Fang, David Kalman, and Douglas M. Ziedonis

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Risk Factors for Relapse and Higher Costs Among Medicaid Members with Opioid Dependence or Abuse: Opioid Agonists, Comorbidities, and Treatment History, Robin E. Clark, Jeffrey D. Baxter, Gideon Aweh, Elizabeth O'Connell, William H. Fisher, and Bruce A. Barton

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Magnitude of and Prognostic Factors Associated With 1-Year Mortality After Hospital Discharge for Acute Decompensated Heart Failure Based on Ejection Fraction Findings, Andrew H. Coles, Mayra Tisminetzky, Jorge L. Yarzebski, Darleen M. Lessard, Joel M. Gore, Chad E. Darling, and Robert J. Goldberg

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Predictors and outcomes of readmission for Clostridium difficile in a national sample of medicare beneficiaries, Courtney E. Collins, M. Didem Ayturk, Frederick A. Anderson Jr., and Heena Santry

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Innovation or rebranding, acute care surgery diffusion will continue, Courtney E. Collins, Patricia L. Pringle, and Heena Santry

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Characterization of functional antibody and memory B-cell responses to pH1N1 monovalent vaccine in HIV-infected children and youth, Donna J. Curtis, Petronella Muresan, Sharon Nachman, Terence Fenton, Kelly M. Richardson, Teresa Dominguez, Patricia M. Flynn, Stephen A. Spector, Coleen K. Cunningham, Anthony Bloom, and Adriana Weinberg

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Health information-seeking on behalf of others: characteristics of "surrogate seekers", Sarah L. Cutrona, Kathleen M. Mazor, Sana N. Vieux, Tana M. Luger, Julie E. Volkman, and Lila J. Finney Rutten

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Testing item response theory invariance of the standardized Quality-of-life Disease Impact Scale (QDIS) in acute coronary syndrome patients: differential functioning of items and test, Nina Deng, Milena D. Anatchkova, Molly E. Waring, Kyung T. Han, and John E. Ware Jr.

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Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection, Laura L. Gibson, Constance Barysauskas, Margaret M. McManus, Sheryl Dooley, Daniele Lilleri, Donna Fisher, Tumul Srivastava, Don J. Diamond, and Katherine Ruiz De Luzuriaga

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Characteristics of Contemporary Patients Discharged From the Hospital After an Acute Coronary Syndrome, Robert J. Goldberg, Jane S. Saczynski, David D. McManus, Molly E. Waring, Richard H. McManus, Jeroan J. Allison, David C. Parish, Darleen M. Lessard, Sharina D. Person, Joel Gore, and Catarina I. Kiefe

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A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection, Thomas C. Greenough, Juerg R. Straubhaar, Larisa Kamga, Eric R. Weiss, Robin M. Brody, Margaret M. McManus, Linda K. Lambrecht, Mohan Somasundaran, and Katherine Ruiz De Luzuriaga

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The Complex Relationship of Race to Outcomes in Heart Failure with Preserved Ejection Fraction, Jerry H. Gurwitz, David J. Magid, David H. Smith, Grace Hsu, Sue Hee Sung, Larry A. Allen, David D. McManus, Robert J. Goldberg, and Alan S. Go

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Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways, Xing He, Jun Xie, Dongmei Zhang, Qin Su, Xue Sai, Ruipu Bai, Chao Chen, Xufeng Luo, Guangping Gao, and Weiqing Pan

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Evaluating the QUIT-PRIMO clinical practice ePortal to increase smoker engagement with online cessation interventions: a national hybrid type 2 implementation study, Thomas K. Houston, Rajani S. Sadasivam, Jeroan J. Allison, Arlene S. Ash, Midge N. Ray, Thomas M. English, Timothy P. Hogan, and Daniel E. Ford

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Declining Long-term Risk of Adverse Events after First-time Community-presenting Venous Thromboembolism: The Population-based Worcester VTE Study (1999 to 2009), Wei Huang, Robert J. Goldberg, A. T. Cohen, Frederick A. Anderson Jr., Catarina I. Kiefe, Joel M. Gore, and Frederick A. Spencer

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Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses, Tianxiao Huan, Jian Rong, Kahraman Tanriverdi, Qingying Meng, Anindya Bhattacharya, David D. McManus, Roby Joehanes, Themistocles L. Assimes, Ruth McPherson, Nilesh J. Samani, Jeanette Erdmann, Heribert Schunkert, Paul Courchesne, Peter J. Munson, Andrew D. Johnson, Christopher J. O'Donnell, Bin Zhang, Martin G. Larson, Jane Freedman, Daniel Levy, and Xia Yang

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Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model, Emily S. Johnson, Kathryn O. Chase, Sarah McGowan, Erica Mondo, Edith L. Pfister, Eric Mick, Randall H. Friedline, Jason K. Kim, Ellen Sapp, Marian DiFiglia, and Neil Aronin

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A television in the bedroom is associated with higher weekday screen time among youth with attention deficit hyperactivity disorder (ADD/ADHD), Charmaine B. Lo, Molly E. Waring, Sherry L. Pagoto, and Stephenie C. Lemon

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Current status of gene therapy for alpha-1 antitrypsin deficiency, Heather S. Loring and Terence R. Flotte

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The impact of acute care surgery on appendicitis outcomes: Results from a national sample of university-affiliated hospitals, John C. Madore, Courtney E. Collins, M. Didem Ayturk, and Heena Santry

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Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework, Madhu Mazumdar; Shari Messinger; Dianne M. Finkelstein; Judith D. Goldberg; Christopher J. Lindsell; Sally C. Morton; Brad H. Pollock; Mohammad H. Rahbar; L. J. Welty; Robert A. Parker; and Biostatistics, Epidemiology, and Research Design (BERD) Key Function Committee of the Clinical and Translational Science Awards (CTSA) Consortium.

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MicroRNAs in platelet function and cardiovascular disease, David D. McManus and Jane Freedman

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Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study), David D. McManus, Kahraman Tanriverdi, Honghuang Lin, Nada Esa, Menhel Kinno, Divakar Mandapati, Stanley Tam, Nsidinanya Okike, Patrick T. Ellinor, John F. Keaney, J. Kevin Donahue, Emelia J. Benjamin, and Jane E. Freedman

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Decision Aids and Shared Decision-Making in Neurocritical Care: An Unmet Need in Our NeuroICUs, Susanne Muehlschlegel, Lori Shutter, Nananda Col, and Robert J. Goldberg

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Attitudes toward Substance Abuse Clients: An Empirical Study of Clinical Psychology Trainees, Chandra R. Mundon, Melissa L. Anderson, and Lisa M. Najavits

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Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila, Yingchao Nie, Qi Li, Alla Amcheslavsky, Juan Carlos Duhart, Alexey Veraksa, Hugo Stocker, Laurel A. Raftery, and Y. Tony Ip

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A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, and Mary M. Lee

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Data from: A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, and Mary M. Lee

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Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels, Adedotun Ogunsua, Amir Y. Shaikh, Mohamed Ahmed, and David D. McManus

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Measuring Diversity and Inclusion in Academic Medicine: The Diversity Engagement Survey, Sharina D. Person, C. Greer Jordan, Jeroan J. Allison, Lisa M. Fink Ogawa, Laura Castillo-Page, Sarah Conrad, Marc A. Nivet, and Deborah L. Plummer

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Heterogeneity of postpartum depression: a latent class analysis, Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium, Kristina M. Deligiannidis, and Samantha Meltzer-Brody

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On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity, Nicholas Renzette, Timothy F. Kowalik, and Jeffrey D. Jensen

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Trends in acute myocardial infarction hospitalizations: Are we seeing the whole picture, Naomi C. Sacks, Arlene S. Ash, Kaushik Ghosh, Amy K. Rosen, John B. Wong, and Allison B. Rosen

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Variations in the implementation of acute care surgery: results from a national survey of university-affiliated hospitals, Heena Santry, John C. Madore, Courtney E. Collins, M. Didem Ayturk, George C. Velmahos, L. D. Britt, and Catarina I. Kiefe

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Quadrimodal distribution of death after trauma suggests that critical injury is a potentially terminal disease, Heena Santry, Charles M. Psoinos, Christopher J. Wilbert, Julie Flahive, Aimee Kroll, Timothy A. Emhoff, and Catarina I. Kiefe

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50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study, Renate B. Schnabel, Philimon Gona, and David D. McManus

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An online social network to increase walking in dog owners: a randomized trial, Kristin L. Schneider, Deirdra Murphy, Cynthia Ferrara, Jessica L. Oleski, Emily Panza, Clara Savage, Brianne Bozzella, Effie Olendzki, Daniel Kern, Stephenie C. Lemon, and Kimberly Gada

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Addition of B-Type Natriuretic Peptide to Existing Clinical Risk Scores Enhances Identification of Patients at Risk for Atrial Fibrillation Recurrence After Pulmonary Vein Isolation, Amir Y. Shaikh, Nada Esa, William Martin-Doyle, Menhel Kinno, Iryna Nieto, Kevin C. Floyd, Clifford Browning, Cynthia Ennis, J. Kevin Donahue, Lawrence S. Rosenthal, and David D. McManus

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A bridge too far? Findings of bridging anticoagulation use and outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF), Amir Y. Shaikh and David D. McManus

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Who Gets Early Tracheostomy?: Evidence of Unequal Treatment at 185 Academic Medical Centers, Joshua J. Shaw and Heena Santry