The goal of the University of Massachusetts Center for Clinical and Translational Science (UMCCTS) is to move laboratory discoveries into treatments for patients, to engage communities in clinical research, and to train a new generation of researchers. Through the center, we will facilitate greater efficiency and productivity of UMass investigators across campuses to enhance the public’s health. The UMass Center for Clinical and Translational Science is part of a national Clinical and Translational Science Award (CTSA) consortium, led by the National Institutes of Health's National Center for Research Resources, which was created to accelerate laboratory discoveries into treatments for patients.
This collection showcases publications that are the result of UMCCTS supported research.
Publications from 2013
Young patients hospitalized with an acute coronary syndrome, Hamza H. Awad, David D. McManus, Frederick A. Anderson Jr., Joel M. Gore, and Robert J. Goldberg
Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel program, Sarah L. Cutrona, Sengwee Toh, Aarthi Iyer, Sarah Foy, Gregory W. Daniel, Vinit P. Nair, Daniel Ng, Melissa G. Butler, Denise M. Boudreau, Susan Forrow, Robert J. Goldberg, Joel M. Gore, David D. McManus, Judith A. Racoosin, and Jerry H. Gurwitz
Greater knowledge and appreciation of commonly-used research study designs, Robert J. Goldberg, David D. McManus, and Jeroan J. Allison
Increased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents, Olga T. Hardy, Albert Kim, Carol A. Ciccarelli, Laura L. Hayman, and Jean Wiecha
Patient-provider secure messaging in VA: variations in adoption and association with urgent care utilization, Stephanie L. Shimada, Timothy P. Hogan, Sowmya R. Rao, Jeroan J. Allison, Ann L. Quill, Hua Feng, Barrett Phillips, Kim M. Nazi, Susan T. Haidary, and Thomas K. Houston
Publications from 2012
A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data, Susan E. Andrade, Leslie R. Harrold, Jennifer Tjia, Sarah L. Cutrona, Jane S. Saczynski, Katherine S. Dodd, Robert J. Goldberg, and Jerry H. Gurwitz
Risk-adjusted payment and performance assessment for primary care, Arlene S. Ash and Randall P. Ellis
Brief depressive symptoms in patients with bipolar disorder: analysis of long-term self-reported data, Michael Bauer, Tasha Glenn, Michael Keil, Rita Bauer, Wendy K. Marsh, Paul Grof, Martin Alda, Kemal Sagduyu, Greg Murray, Danilo Quiroz, Christopher Baethge, and Peter C. Whybrow
Atherosclerotic Risk Factors and Their Association With Hospital Mortality Among Patients With First Myocardial Infarction (from the National Registry of Myocardial Infarction), John G. Canto, Catarina I. Kiefe, William J. Rogers, Eric D. Peterson, Paul D. Frederick, William J. French, C. Michael Gibson, Charles V. Pollack Jr., Joseph P. Ornato, Robert J. Zalenski, Jan Penney, Alan J. Tiefenbrunn, Philip Greenland, and NRMI Investigators
Detecting Graded Exposure Effects: A Report on an East Boston Pregnancy Cohort, (Julia) Hua Fang, Vanja Dukic, Kate E. Pickett, Lauren Wakschlag, and Kimberly Andrews Espy
Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents, Olga T. Hardy, Jean Wiecha, Albert Kim, Carlos Salas, Rayna Briceno, Kwesi Moody, Joan Becker, Greer Glazer, Carol A. Ciccarelli, Ling Shi, and Laura L. Hayman
Gender Differences in the Fagerström Test for Nicotine Dependence in Korean Americans, Sun Kim, (Julia) Hua Fang, Joseph R. DiFranza, Douglas M. Ziedonis, and Grace X. Ma
Progression of female reproductive stages associated with bipolar illness exacerbation, Wendy K. Marsh, Terence A. Ketter, Sybil L. Crawford, Julia V. Johnson, Aimee R. Kroll-Desrosiers, and Anthony J. Rothschild
Trends in atrial fibrillation in patients hospitalized with an acute coronary syndrome, David D. McManus, Wei Huang, Kunal V. Domakonda, Jeanine Ward, Jane S. Saczynski, Joel M. Gore, and Robert J. Goldberg
A novel application for the detection of an irregular pulse using an iPhone 4S in patients with atrial fibrillation, David D. McManus, Jinseok Lee, Oscar Maitas, Nada Esa, Rahul Pidikiti, Alex Carlucci, Josephine Harrington, Eric Mick, and Ki H. Chon
An update on the prognosis of patients with atrial fibrillation, David D. McManus, Michael Rienstra, and Emelia J. Benjamin
The dangers of being a "weekend warrior": A new call for injury prevention efforts, Charles M. Psoinos, A. Emhoff Timothy, W. Brian Sweeney, Jennifer F. Tseng, and Heena P. Santry
Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β, Sohan Punia, Kyle K. Rumery, Elizabeth A. Yu, Christopher M. Lambert, Abner L. Notkins, and David R. Weaver
Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge, Margaret A. Riley, Sandra M. Robinson, Christopher M. Roy, Morgan Dennis, Vivian Liu, and Robert L. Dorit
A systematic review of validated methods for identifying heart failure using administrative data, Jane S. Saczynski, Susan E. Andrade, Leslie R. Harrold, Jennifer Tjia, Sarah L. Cutrona, Katherine S. Dodd, Robert J. Goldberg, and Jerry H. Gurwitz
The role of unconscious bias in surgical safety and outcomes, Heena P. Santry and Sherry M. Wren
Speckle echocardiographic left atrial strain and stiffness index as predictors of maintenance of sinus rhythm after cardioversion for atrial fibrillation: a prospective study, Amir Y. Shaikh, Abhishek Mann, Umar A. Khan, Gerard P. Aurigemma, Jeffrey C. Hill, Jennifer L. Kane, Dennis A. Tighe, Eric Mick, and David D. McManus
Transitions, Risks, and Actions in Coronary Events--Center for Outcomes Research and Education (TRACE-CORE): Design and Rationale, Molly E. Waring, Richard H. McManus, Jane S. Saczynski, Milena D. Anatchkova, David D. McManus, Randolph Devereaux, Robert J. Goldberg, Jeroan J. Allison, and Catarina I. Kiefe
The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials, Charles Weijer, Jeremy M. Grimshaw, Martin P. Eccles, Andrew D. McRae, Angela White, Jamie C. Brehaut, Monica Taljaard, Ottawa Ethics of Cluster Randomized Trials Consensus Group, and Catarina I. Kiefe
Is it worth looking? Abdominal imaging after pancreatic cancer resection: a national study, Elan R. Witkowski, Jillian K. Smith, Elizaveta Ragulin-Coyne, Sing Chau Ng, Shimul A. Shah, and Jennifer F. Tseng
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao
Genome-wide identification and characterization of replication origins by deep sequencing, Jia Xu, Yoshimi Yanagisawa, Alexander M. Tsankov, Christopher Hart, Keita Aoki, Naveen Kommajosyula, Kathleen E. Steinmann, James Bochicchio, Carsten Russ, Aviv Regev, Oliver J. Rando, Chad Nusbaum, Hironori Niki, Patrice Milos, Zhiping Weng, and Nicholas R. Rhind
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Haojian Zhang, Huawei Li, Hualin S. Xi, and Shaoguang Li
Publications from 2011
Food insufficiency and health services utilization in a national sample of homeless adults, Travis P. Baggett, Daniel E. Singer, Sowmya R. Rao, James J. O'Connell, Monica Bharel, and Nancy A. Rigotti
Neighborhood socioeconomic status predictors of physical activity through young to middle adulthood: the CARDIA study, Janne Boone-Heinonen, Ana V. Diez-Roux, Catarina I. Kiefe, Cora E. Lewis, David K. Guilkey, and Penny Gordon-Larsen
Fast food restaurants and food stores: longitudinal associations with diet in young to middle-aged adults: the CARDIA study, Janne Boone-Heinonen, Penny Gordon-Larsen, Catarina I. Kiefe, James M. Shikany, Cora E. Lewis, and Barry M. Popkin
Alcohol Screening and Risk of Postoperative Complications in Male VA Patients Undergoing Major Non-cardiac Surgery, Katharine A. Bradley, Anna D. Rubinsky, Haili Sun, Chris L. Bryson, Michael J. Bishop, David K. Blough, William G. Henderson, Charles Maynard, Mary T. Hawn, Hanne Tonnesen, Grant Hughes, Lauren A. Beste, Alex H.S. Harris, Eric J. Hawkins, Thomas K. Houston, and Daniel R. Kivlahan
What Should We Include in a Cultural Competence Curriculum? An Emerging Formative Evaluation Process to Foster Curriculum Development, Katie Crenshaw, Richard M. Shewchuk, Haiyan Qu, Lisa J. Stanton, Judy Ann Bigby, Thomas K. Houston, Jeroan J. Allison, and Carlos A. Estrada
Assessment of differential item functioning in the experiences of discrimination index: the Coronary Artery Risk Development in Young Adults (CARDIA) Study, Timothy J. Cunningham, Lisa F. Berkman, Steven L. Gortmaker, Catarina I. Kiefe, David R. Jacobs Jr., Teresa E. Seeman, and Ichiro Kawachi
A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C, Jules L. Dienstag, Marc G. Ghany, Timothy R. Morgan, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Hae-Young Kim, Leonard B. Seeff, Gyongyi Szabo, Elizabeth C. Wright, Richard K. Sterling, Gregory T. Everson, Karen L. Lindsay, William M. Lee, Anna S. F. Lok, Chihiro Morishima, Anne M. Stoddard, and James E. Everhart
A new look at quantifying tobacco exposure during pregnancy using fuzzy clustering, Hua Fang, Craig Johnson, Christian Stopp, and Kimberly Andrews Espy
Physician and Patient Influences on Provider Performance: {beta}-Blockers in Post-Myocardial Infarction Management in the MI-Plus Study, Ellen M. Funkhouser, Thomas K. Houston, Deborah A. Levine, Joshua S. Richman, Jeroan J. Allison, and Catarina I. Kiefe
Recruitment activities for a nationwide, population-based, group-randomized trial: the VA MI-Plus study, Ellen M. Funkhouser, Deborah A. Levine, Joe K. Gerald, Thomas K. Houston, Nancy K. Johnson, Jeroan J. Allison, and Catarina I. Kiefe
Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults, Jian Gong, Hannia Campos, Stephen T. McGarvey, Zhijin Wu, Robert J. Goldberg, and Ana Baylin
Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine, Jian Gong, Hannia Campos, Stephen McGarvey, Zhijin Wu, Robert J. Goldberg, and Ana Baylin
Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity, Olga T. Hardy, Richard A. Perugini, Sarah M. Nicoloro, Karen A. Gallagher-Dorval, Vishwajeet Puri, Juerg R. Straubhaar, and Michael P. Czech
Social isolation, C-reactive protein, and coronary heart disease mortality among community-dwelling adults, Kathi L. Heffner, Molly E. Waring, Mary B. Roberts, Charles B. Eaton, and Robert Gramling
Geographic and demographic variability in 20-year hypertension incidence: the CARDIA study, Deborah A. Levine, Cora E. Lewis, O. Dale Williams, Monika M. Safford, Kiang Liu, David A. Calhoun, Yongin Kim, David R. Jacobs Jr., and Catarina I. Kiefe
Racial/ethnic disparities in access to physician care and medications among US stroke survivors, Deborah A. Levine, M. V. Neidecker, Catarina I. Kiefe, S. Karve, L. S. Williams, and Jeroan J. Allison
Racial variation in willingness to trade financial resources for life-prolonging cancer treatment, Michelle Y. Martin, Maria Pisu, Robert A. Oster, Julie M. Urmie, Deborah Schrag, Haiden A. Huskamp, Jeannette Lee, Catarina I. Kiefe, and Mona N. Fouad
Activating peripheral arterial disease patients to reduce cholesterol: a randomized trial, Mary McGrae McDermott, George W. Reed, Philip Greenland, Kathleen M. Mazor, Sherry L. Pagoto, Judith K. Ockene, Rex Graff, Philip A. Merriam, Katherine Leung, Larry Manheim, Melina R. Kibbe, Barbara C. Olendzki, William H. Pearce, and Ira S. Ockene
30-year trends in heart failure in patients hospitalized with acute myocardial infarction, David D. McManus, Marcello Chinali, Jane S. Saczynski, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, Darleen M. Lessard, and Robert J. Goldberg
Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI, David D. McManus, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, Darleen M. Lessard, and Robert J. Goldberg
Thirty-year (1975 to 2005) trends in the incidence rates, clinical features, treatment practices, and short-term outcomes of patients [less than] 55 years of age hospitalized with an initial acute myocardial infarction, David D. McManus, Stephen M. Piacentine, Darleen M. Lessard, Joel M. Gore, Jorge L. Yarzebski, Frederick A. Spencer, and Robert J. Goldberg
Socioeconomic status and polycystic ovary syndrome, Sharon Stein Merkin, Ricardo Azziz, Teresa E. Seeman, Ronit Calderon-Margalit, Martha L. Daviglus, Catarina I. Kiefe, Karen A. Matthews, Barbara Sternfeld, and David S. Siscovick
The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian
Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction, Hoa L. Nguyen, Jane S. Saczynski, Joel M. Gore, Molly E. Waring, Darleen M. Lessard, Jorge L. Yarzebski, George W. Reed, Frederick A. Spencer, Shu-Xia Li, and Robert J. Goldberg
Venous thromboembolism in patients with reduced estimated GFR: a population-based perspective, Amisha M. Parikh, Frederick A. Spencer, Darleen M. Lessard, Catherine Emery, Ana Baylin, Crystal Linkletter, and Robert J. Goldberg
Cognitive Mapping Tobacco Control Advice for Dentistry: A Dental PBRN Study, Haiyan Qu, Thomas K. Houston, Jessica H. Williams, Gregg H. Gilbert, and Richard M. Shewchuk
Electronic health records in small physician practices: availability, use, and perceived benefits, Sowmya R. Rao, Catherine M. DesRoches, Karen Donelan, Eric G. Campbell, Paola D. Miralles, and Ashish K. Jha
Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik
Professional values and reported behaviours of doctors in the USA and UK: quantitative survey, Martin Roland, Sowmya R. Rao, Bonnie Sibbald, Mark Hann, Stephen Harrison, Alex Walter, Bruce Guthrie, Catherine M. DesRoches, Timothy G. Ferris, and Eric G. Campbell
Randomized trial of a literacy-sensitive, culturally tailored diabetes self-management intervention for low-income latinos: latinos en control, Milagros C. Rosal, Ira S. Ockene, Angela Restrepo, Mary Jo White, Amy Borg, Barbara C. Olendzki, Jeffrey Scavron, Lucy M. Candib, Garry Welch, and George W. Reed
Development of an interactive, Web-delivered system to increase provider-patient engagement in smoking cessation, Rajani S. Sadasivam, Kathryn Delaughter, Katie Crenshaw, Heather J. Sobko, Jessica H. Williams, Heather L. Coley, Midge N. Ray, Daniel E. Ford, Jeroan J. Allison, and Thomas K. Houston
Patient complexity and diabetes quality of care in rural settings, Amanda H. Salanitro, Monika M. Safford, Thomas K. Houston, Jessica H. Williams, Fernando Ovalle, Pamela Payne-Foster, Jeroan J. Allison, and Carlos A. Estrada
Temporal Trends in Presentation for Outpatient HIV Medical Care 2000-2010: Implications for Short-term Mortality, Paula S. Seal, David A. Jackson, Eric Chamot, James H. Willig, Christa R. Nevin, Jeroan J. Allison, James L. Raper, Mirjam Kempf, Joseph E. Schumacher, Michael S. Saag, and Michael J. Mugavero
Weight and mortality following heart failure hospitalization among diabetic patients, Molly E. Waring, Jane S. Saczynski, David D. McManus, Michael Zacharias, Darleen M. Lessard, Joel M. Gore, and Robert J. Goldberg
Six-month mortality and cardiac catheterization in non-ST-segment elevation myocardial infarction patients with anemia, Wen-Chih Wu, Molly E. Waring, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore, and Robert J. Goldberg
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains, Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore