Title

A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

6-14-2010

Document Type

Article

Medical Subject Headings

Amidines; Arginine; Catalytic Domain; Cell Line; Enzyme Inhibitors; Humans; Methylation; Peptides; Protein-Arginine N-Methyltransferases

Disciplines

Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry | Therapeutics

Rights and Permissions

Citation: Chembiochem. 2010 Jun 14;11(9):1219-23. doi: 10.1002/cbic.201000209. Link to article on publisher's site

Comments

At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.

Related Resources

Link to Article in PubMed

Keywords

Cl-amidine, enzymes, inhibitors, protein arginine methyltransferase, transcription