The Program in Systems Biology was established as a new interdisciplinary research program at UMass Medical School in 2012. The goal of systems biology as a field is to understand biological processes at a systems level rather than at the level of individual molecules. Systems biology capitalizes on technological advances in the areas of genomics and high-throughput instrumentation, with strong links to computational biology, math, statistics and bioinformatics. Leading the new program as co-directors are Job Dekker, PhD, professor of biochemistry & molecular pharmacology and molecular medicine and a member of the Program in Gene Function and Expression; and Marian Walhout, PhD, professor of molecular medicine. This collection showcases the journal articles, book chapters, and other publications and presentations written by faculty and researchers of the Program in Systems Biology at the University of Massachusetts Medical School.

Follow

Publications from 2004

PDF

A mechanical basis for chromosome function, Nancy Kleckner, Denise Zickler, Gareth H. Jones, Job Dekker, Ruth Padmore, Jim Henle, and John N. Hutchinson

Publications from 2003

Link

A closer look at long-range chromosomal interactions, Job Dekker

Link

Integrating 'omic' information: a bridge between genomics and systems biology, Hui Ge, Albertha J. M. Walhout, and Marc Vidal

Publications from 2002

Link

Capturing chromosome conformation, Job Dekker, Karsten Rippe, Martijn Dekker, and Nancy Kleckner

Link

Integrated version of reverse two-hybrid system for the postproteomic era, Hideki Endoh, Sylvie Vincent, Yves Jacob, Eleonore Real, Albertha J. M. Walhout, and Marc Vidal

PDF

MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans, Nancy N. Huang, Darcy E. Mootz, Albertha J. M. Walhout, Marc Vidal, and Craig P. Hunter

Link

Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline, Albertha J. M. Walhout, Jerome Reboul, Olena Shtanko, Nicolas Bertin, Philippe Vaglio, Hui Ge, Hongmei Lee, Lynn Doucette-Stamm, Kristin C. Gunsalus, Aaron J. Schetter, Diane G. Morton, Kenneth J. Kemphues, Valerie Reinke, Stuart K. Kim, Fabio Piano, and Marc Vidal

Publications from 2001

Link

A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome, Anne Davy, Paul Bello, Nicolas Thierry-Mieg, Philippe Vaglio, Joseph Hitti, Lynn Doucette-Stamm, Danielle Thierry-Mieg, Jerome Reboul, Simon J. Boulton, Albertha J. M. Walhout, Olivier Coux, and Marc Vidal

Link

High-throughput yeast two-hybrid assays for large-scale protein interaction mapping, Albertha J. M. Walhout and Marc Vidal

Link

Protein interaction maps for model organisms, Albertha J. M. Walhout and Marc Vidal

Publications from 2000

Link

A green fluorescent protein-based reverse two-hybrid system: application to the characterization of large numbers of potential protein-protein interactions, Hideki Endoh, Albertha J. M. Walhout, and Marc Vidal

Link

Yeast two-hybrid systems and protein interaction mapping projects for yeast and worm, Albertha J. M. Walhout, Simon J. Boulton, and Marc Vidal

Link

GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes, Albertha J. M. Walhout, Gary F. Temple, Michael A. Brasch, James L. Hartley, Monique A. Lorson, Sander van den Heuvel, and Marc Vidal

Publications from 1999

Link

Protein interaction mapping in C. elegans using proteins involved in vulval development, Albertha J. M. Walhout, Raffaella Sordella, Xiaowei Lu, James L. Hartley, Gary F. Temple, Michael A. Brasch, Nicolas Thierry-Mieg, and Marc Vidal

PDF

A genetic strategy to eliminate self-activator baits prior to high-throughput yeast two-hybrid screens, Albertha J. M. Walhout and Marc Vidal

Publications from 1998

Link

Sequences flanking the E-box contribute to cooperative binding by c-Myc/Max heterodimers to adjacent binding sites, Albertha J. M. Walhout, P. C. van der Vliet, and H. Th. M. Timmers

Publications from 1997

PDF

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene, Albertha J. M. Walhout, J. M. Gubbels, R. Bernards, P. C. van der Vliet, and H. Th. M. Timmers

Publications from 1993

PDF

E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-beta 2 promoter activation, Frank A. E. Kruyt, Gert E. Folkers, Albertha J. M. Walhout, Bas-jan M. van der Leede, and Paul T. van der Saag