Mapping the 3D genome: Aiming for consilience
Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
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Biochemistry, Biophysics, and Structural Biology | Cell Biology | Genetics and Genomics | Systems Biology
The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.
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Citation: Nat Rev Mol Cell Biol. 2016 Nov 21;17(12):741-742. doi: 10.1038/nrm.2016.151. Link to article on publisher's site
Chromosome conformation capture-based methods, Microscopy, Nuclear organization
Nature reviews. Molecular cell biology
Dekker, Job, "Mapping the 3D genome: Aiming for consilience" (2016). Program in Systems Biology Publications and Presentations. 96.