Long-Range Chromatin Interactions

UMMS Affiliation

Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology



Document Type



Genomics | Molecular Biology | Systems Biology


To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.

Rights and Permissions

Citation: Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10). pii: a019356. doi: 10.1101/cshperspect.a019356.. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Cold Spring Harbor perspectives in biology

PubMed ID