Title

A closer look at long-range chromosomal interactions

UMMS Affiliation

Program in Gene Function and Expression; Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Date

6-27-2003

Document Type

Article

Medical Subject Headings

Animals; Binding Sites; Chromatin; Chromosome Mapping; DNA; Globins; Humans; Locus Control Region

Disciplines

Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Systems Biology

Abstract

Higher-order chromosome organization is emerging as a major determinant of gene regulation. Although the structure of chromatin at the level of individual nucleosomes has been studied in considerable detail, less is known about higher levels of organization. Two new methods have been developed that can be used to obtain detailed information about the higher-order folding of chromatin. Using these methods, long-range looping interactions have been shown to occur upon activation of the murine beta-globin locus, explaining the long-standing question of how gene regulatory elements can act at large genomic distances from their target genes.

Rights and Permissions

Citation: Trends Biochem Sci. 2003 Jun;28(6):277-80. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Trends in biochemical sciences

PubMed ID

12826398