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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyProgram in Systems Biology
Document Type
Journal ArticlePublication Date
2014-11-06Keywords
BioinformaticsChromatin structure
Chromosome conformation capture
Deep sequencing
Hi-C
Bioinformatics
Computational Biology
Genetics and Genomics
Systems Biology
Metadata
Show full item recordAbstract
Over the last decade, development and application of a set of molecular genomic approaches based on the chromosome conformation capture method (3C), combined with increasingly powerful imaging approaches, have enabled high resolution and genome-wide analysis of the spatial organization of chromosomes. The aim of this paper is to provide guidelines for analyzing and interpreting data obtained with genome-wide 3C methods such as Hi-C and 3C-seq that rely on deep sequencing to detect and quantify pairwise chromatin interactions.Source
Methods. 2014 Nov 6. pii: S1046-2023(14)00358-2. doi: 10.1016/j.ymeth.2014.10.031. [Epub ahead of print]. Link to article on publisher's siteDOI
10.1016/j.ymeth.2014.10.031Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49934PubMed ID
25448293Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ymeth.2014.10.031