Genetic adaptation to diet preserves longevity
Program in Systems Biology; Program in Molecular Medicine
Cell and Developmental Biology | Cellular and Molecular Physiology | Genetics and Genomics | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition | Systems Biology
Diet affects cellular metabolism and organismal life history traits. Pang and Curran (2014) use Caenorhabditis elegans and its bacterial diets to unveil genetic perturbations in proline catabolism that shorten lifespan, but, only on specific Escherichia coli diets, thereby unveiling a genome-encoded adaptive response to different nutritional states.
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Citation: Walhout AJ. Genetic adaptation to diet preserves longevity. Cell Metab. 2014 Feb 4;19(2):177-8. doi: 10.1016/j.cmet.2014.01.006. Link to article on publisher's website