Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?

UMMS Affiliation

Program in Systems Biology



Document Type



Molecular Biology | Structural Biology | Systems Biology


We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also underlie many properties of long-range transcriptional regulation. Several observations suggest that TADs can indeed provide a structural basis to regulatory landscapes, by controlling enhancer sharing and allocation. We also discuss how TADs may shape the evolution of chromosomes, by causing maintenance of synteny over large chromosomal segments. Finally we suggest a series of experiments to challenge these ideas and provide concrete examples illustrating how they could be practically applied.

Rights and Permissions

Citation: Bioessays. 2013 Sep;35(9):818-28. doi: 10.1002/bies.201300040. Link to article on publisher's website

Related Resources

Link to article in PubMed


chromatin domains, chromatin folding, chromosome conformation capture (3C), long-range transcriptional regulation, regulatory landscapes, topologically associating chromosome domains

Journal Title

BioEssays : news and reviews in molecular, cellular and developmental biology

PubMed ID