Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans
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UMass Chan Affiliations
Program in Gene Function and ExpressionProgram in Molecular Medicine
Program in Systems Biology
Document Type
Journal ArticlePublication Date
2013-03-28Keywords
Caenorhabditis elegansCaenorhabditis elegans Proteins
Insulin
Gene Expression Regulation, Developmental
Diet
Biochemical Phenomena, Metabolism, and Nutrition
Cell and Developmental Biology
Genetics and Genomics
Systems Biology
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Show full item recordAbstract
Dietary composition has major effects on physiology. Here, we show that developmental rate, reproduction, and lifespan are altered in C. elegans fed Comamonas DA1877 relative to those fed a standard E. coli OP50 diet. We identify a set of genes that change in expression in response to this diet and use the promoter of one of these (acdh-1) as a dietary sensor. Remarkably, the effects on transcription and development occur even when Comamonas DA1877 is diluted with another diet, suggesting that Comamonas DA1877 generates a signal that is sensed by the nematode. Surprisingly, the developmental effect is independent from TOR and insulin signaling. Rather, Comamonas DA1877 affects cyclic gene expression during molting, likely through the nuclear hormone receptor NHR-23. Altogether, our findings indicate that different bacteria elicit various responses via distinct mechanisms, which has implications for diseases such as obesity and the interactions between the human microbiome and intestinal cells.Source
Cell. 2013 Mar 28;153(1):240-52. doi: 10.1016/j.cell.2013.02.049. Link to article on publisher's websiteDOI
10.1016/j.cell.2013.02.049Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49906PubMed ID
23540701Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2013.02.049