Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Causes in New York
Department of Surgery
Medical Subject Headings
Hepatectomy; Tissue Donors; Liver Transplantation
INTRODUCTION: Right lobe donor hepatectomy (RLDH) is a potential source of liver allografts given the ongoing shortage of deceased donor organs available. Since there is no live donor registry in the United States, a population-based, unsolicited state-wide analysis has yet to be reported.
METHODS: The New York (NY) State Inpatient Database was used to query 1,524 elective liver lobectomies performed from 2001 to 2006. RLDH were identified in this cohort (n = 195; 13%). Most common indications for elective right lobe hepatectomy (ERH) were metastatic colon cancer (50%) and hepatocellular carcinoma (HCC) (34%). Primary outcomes were mortality, perioperative resources and major postoperative complications.
RESULTS: After a dramatic drop in 2002, there was a slow increase in RLDH from 2003 to 2006 in New York. Donors were younger (median age 36 vs. 60 years, P < 0.0001) and healthier (75% with no comorbidities vs. 18%, P < 0.0001) than patients undergoing ERH for other causes. Median length of hospital stay was 7 days in both groups. Donors were less likely to require blood transfusion (22.6 vs. 62.8%, P < 0.0001) and received less blood (mean 0.10 units vs. 2.4 units). Major post-operative complications based on the Clavien classification occurred in only 2.6% of donor cases compared to 13.8% in non-donors (P < 0.0001). There was one RLDH in-hospital mortality (0.5%) in New York compared to 4.3% after ERH (P = 0.003).
CONCLUSIONS: This study represents one of the first unsolicited regional analyses of donor morbidity and resource utilization for RLDH and further emphasizes the need and utility of a live donor registry.
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Citation: Dig Dis Sci. 2011 Jun;56(6):1869-75. Epub 2010 Nov 27. Link to article on publisher's site
Burr, Andrew T.; Csikesz, Nicholas G.; Gonzales, Earl; Tseng, Jennifer F.; Saidi, Reza F.; Bozorgzadeh, Adel; and Shah, Shimul A., "Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Causes in New York" (2011). Surgery Publications and Presentations. Paper 80.