This collection showcases journal articles and other publications authored by researchers in the Cancer, Stem Cell and Bone Biology Program, headed by principal investigators Gary S. Stein, Janet L. Stein, Jane B. Lian, and Andre J. van Wijnen, in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2012

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A Runx2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation, Syed A. Ali, Jason Dobson, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, Sayyed K. Zaidi, and Gary S. Stein (Journal of cell science)

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TRAP-1, the mitochondrial Hsp90, Dario C. Altieri, Gary S. Stein, Jane B. Lian, and Lucia R. Languino (Biochimica et biophysica acta)

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Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2), Diah S. Bramono, Sadasivam Murali, Bina Rai, Ling Ling, Wei Theng Poh, Zophia Xuehui Lim, Gary S. Stein, Victor Nurcombe, Andre J. Van Wijnen, and Simon M. Cool (Bone)

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Neural Crest Deletion of Dlx3 Leads to Major Dentin Defects through Down-regulation of Dspp, Olivier Duverger, Angela Zah, Juliane Isaac, Hong-Wei Sun, Anne K. Bartels, Jane B. Lian, Ariane Berdal, Joonsung Hwang, and Maria I. Morasso (The Journal of biological chemistry)

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Vitamin k-dependent carboxylation of osteocalcin: friend or foe, Caren M. Gundberg, Jane B. Lian, and Sarah L. Booth (Advances in nutrition (Bethesda, Md.))

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Heparan Sulfate Enhances the Self-Renewal and Therapeutic Potential of Mesenchymal Stem Cells from Human Adult Bone Marrow, Torben Helledie, Christian Dombrowski, Bina Rai, Zophia X.H. Lim, Ian Lee Hock Hin, David A. Rider, Gary S. Stein, Wanjin Hong, Andre J. Van Wijnen, James H. Hui, Victor Nurcombe, and Simon M. Cool (Stem cells and development)

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Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells, Hee-Jeong Im, Xin Li, Jae-Sung Kim, Michael B. Ellman, Gary S. Stein, Brian Cole, Ranjan KC, Gabriella Cs-Szabo, and Andre J. Van Wijnen (Journal of cellular physiology)

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miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma, Kevin B. Jones, Zaidoun Salah, Sara Del Mare, Marco Galasso, Eugenio Gaudio, Gerard J. Nuovo, Francesca Lovat, Kimberly T. LeBlanc, Jeff Patatini, R. Lor Randall, Stefano Volinia, Gary S. Stein, Carlo M. Croce, Jane B. Lian, and Rami I. Aqeilan (Cancer research)

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Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc, Jae-Sung Kim, Michael B. Ellman, Howard S. An, Dongyao Yan, Andre J. Van Wijnen, Gillian Murphy, David W. Hoskin, and Hee-Jeong Im (Journal of cellular physiology)

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MicroRNA control of bone formation and homeostasis, Jane B. Lian, Gary S. Stein, Andre J. Van Wijnen, Janet L. Stein, Mohammad Q. Hassan, Tripti Gaur, and Ying Zhang (Nature reviews. Endocrinology)

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Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family, Xin Li, Michael B. Ellman, Jeffrey S. Kroin, Di Chen, Dongyao Yan, Katalin Mikecz, K. C. Ranjan, Xiao Guozhi, Gary S. Stein, Su-Gwan Kim, Brian Cole, Andre J. Van Wijnen, and Hee-Jeong Im (Journal of cellular biochemistry)

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Identification of RUNX3 as a component of the MST/Hpo signaling pathway, Boram Min, Min-Kyu Kim, Joo-Won Zhang, Jiyeon Kim, Kwang-Chul Chung, Byung-Chul Oh, Gary S. Stein, Yong-Hee Lee, Andre J. Van Wijnen, and Suk-Chul Bae (Journal of cellular physiology)

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The architectural organization of human stem cell cycle regulatory machinery, Gary S. Stein, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, Martin A. Montecino, Ricardo F. Medina, Kristina Kapinas, Prachi N. Ghule, Rodrigo Grandy, Sayyed K. Zaidi, and Klaus A. Becker (Current pharmaceutical design)

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Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility, Margaretha Van der Deen, Jacqueline Akech, David S. Lapointe, Sneha Gupta, Daniel W. Young, Martin A. Montecino, Mario Galindo, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (The Journal of biological chemistry)

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Control of mesenchymal lineage progression by microRNAs targeting the skeletal gene regulators Trps1 and Runx2, Ying Zhang, Ronglin Xie, Jonathan A. R. Gordon, Kimberly T. LeBlanc, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (The Journal of biological chemistry)

Submissions from 2011

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The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element, Chung-youl Choe, Hogyoung Kim, Jinping Dong, Andre J. Van Wijnen, Ping-Yee Law, and Horace H. Loh (Gene)

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Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma, Sara Del Mare, Kyle C. Kurek, Gary S. Stein, Jane B. Lian, and Rami I. Aqeilan (American journal of cancer research)

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Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation, Joyce Emons, Bas E. Dutilh, Eva Decker, Heide Pirzer, Carsten Sticht, Norbert Gretz, Gudrun Rappold, Ewan R. Cameron, James C. Neil, Gary S. Stein, Andre J. Van Wijnen, Jan Maarten Wit, Janine N. Post, and Marcel Karperien (The Journal of endocrinology)

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Reprogramming the pluripotent cell cycle: restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells, Prachi N. Ghule, Ricardo F. Medina, Christopher Joachim Lengner, Matthew Mandeville, Meng Qiao, Zbigniew Dominski, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Journal of cellular physiology)

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Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex, Jonathan A. R. Gordon, Mohammad Q. Hassan, Matthew Koss, Martin A. Montecino, Licia Selleri, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Cells, tissues, organs)

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TIEG1/KLF10 Modulates Runx2 Expression and Activity in Osteoblasts, John R. Hawse, Muzaffer Cicek, Sarah B. Grygo, Elizabeth S. Bruinsma, Nalini M. Rajamannan, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Merry Jo Oursler, Malayannan Subramaniam, and Thomas C. Spelsberg (PloS one)

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C/EBPbeta binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells, Berta Henriquez, Matias Hepp, Paola Merino, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Martin A. Montecino (Journal of cellular physiology)

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Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease, Byoung H. Kang, M. Tavecchio, Hira Lal Goel, Chung-Cheng Hsieh, David S. Garlick, Christopher M. Raskett, Jane B. Lian, Gary S. Stein, Lucia R. Languino, and Dario C. Altieri (British journal of cancer)

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Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop, Sundeep Khosla, Teresita M. Bellido, Marc K. Drezner, Catherine M. Gordon, Tamara B. Harris, Douglas P. Kiel, Barbara E. Kream, Meryl S. LeBoff, Jane B. Lian, Charlotte A. Peterson, Clifford J. Rosen, John P. Williams, Karen K. Winer, and Sherry S. Sherman (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)

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Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis, Jae-Sung Kim, Jeffrey S. Kroin, Asokumar Buvanendran, Xin Li, Andre J. Van Wijnen, Kenneth J. Tuman, and Hee-Jeong Im (Arthritis and rheumatism)

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The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain, Jae-Sung Kim, Jeffrey S. Kroin, Xin Li, Howard S. An, Asokumar Buvanendran, Dongyao Yan, Kenneth J. Tuman, Andre J. Van Wijnen, Di Chen, and Hee-Jeong Im (Arthritis research and therapy)

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation, Julie C. Liu, Christopher Joachim Lengner, Tripti Gaur, Yang Lou, Sadiq Hussain, Marci D. Jones, Brent Borodic, Jennifer L. Colby, Heather Anne Steinman, Andre J. Van Wijnen, Janet L. Stein, Stephen N. Jones, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development, Lijun Liu, Ronglin Xie, Sadiq Hussain, Jane B. Lian, Jaime A. Rivera-Perez, Stephen N. Jones, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Gene)

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MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis, Xin Li, Gary Gibson, Jae-Sung Kim, Jeffrey S. Kroin, Shunbin Xu, Andre J. Van Wijnen, and Hee-Jeong Im (Gene)

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Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain, Xin Li, Jae-Sung Kim, Andre J. Van Wijnen, and Hee-Jeong Im (Molecular biology reports)

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Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway, Melissa M. Matzelle, Maxime A. Gallant, Keith W. Condon, Nicole Walsh, Catherine A. Manning, Gary S. Stein, Jane B. Lian, David B. Burr, and Ellen M. Gravallese (Arthritis and rheumatism)

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Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts, Meghan E. McGee-Lawrence, Angela L. McCleary-Wheeler, Frank J. Secreto, David F. Razidlo, Minzhi Zhang, Bridget A. Stensgard, Xiaodong Li, Gary S. Stein, Jane B. Lian, and Jennifer J. Westendorf (Bone)

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Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression, Shirwin M. Pockwinse, Krishna P. Kota, Alexandre J. C. Quaresma, Anthony N. Imbalzano, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jeffrey A. Nickerson (Journal of cellular physiology)

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Metastatic bone disease: Role of transcription factors and future targets, Jitesh Pratap, Jane B. Lian, and Gary S. Stein (Bone)

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An architectural genetic and epigenetic perspective, Gary S. Stein, Janet L. Stein, Andre J. Van Wijnen, Sayyed K. Zaidi, Jeffrey A. Nickerson, Martin A. Montecino, and Daniel W. Young (Integrative biology : quantitative biosciences from nano to macro)

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Fibroblast Growth Factor Receptor 1 is Principally Responsible for Fibroblast Growth factor 2-induced catabolic activities in human articular chondrocytes, Gongyao Yan, Di Chen, Simon M. Cool, Andre J. Van Wijnen, Katalin Mikecz, Gillian Murphy, and Hee-Jeong Im (Arthritis research and therapy)

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Bookmarking the genome: maintenance of epigenetic information, Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein (The Journal of biological chemistry)

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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2, Ying Zhang, Ronglin Xie, Carlo M. Croce, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

Submissions from 2010

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions, Jacqueline Akech, John J. Wixted, Krystin Bedard, Margaretha Van der Deen, Sadiq Hussain, T. A. Guise, Andre J. Van Wijnen, Janet L. Stein, Lucia R. Languino, Dario C. Altieri, Jitesh Pratap, E. Keller, Gary S. Stein, and Jane B. Lian (Oncogene)

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Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes, Syed A. Ali, Sayyed K. Zaidi, James G. Dobson Jr., A. Rauf Shakoori, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Recruitment and subnuclear distribution of the regulatory machinery during 1alpha,25-dihydroxy vitamin D3-mediated transcriptional upregulation in osteoblasts, Gloria Arriagada, Berta Henriquez, Daniel Moena, Paola Merino, Cinthya Ruiz-Tagle, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Martin A. Montecino (The Journal of steroid biochemistry and molecular biology)

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1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA, Gloria Arriagada, Roberto Paredes, Andre J. Van Wijnen, Jane B. Lian, Brigitte van Zundert, Gary S. Stein, Janet L. Stein, and Martin A. Montecino (Journal of cellular physiology)

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The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes, Rachit Bakshi, Mohammad Q. Hassan, Jitesh Pratap, Jane B. Lian, Martin A. Montecino, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, and Gary S. Stein (Journal of cellular physiology)

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Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells, Klaus A. Becker, Prachi N. Ghule, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming, Klaus A. Becker, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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International stem cell registries, Joeri Borstlap, Mai X. Luong, Heather M. Rooke, B. Aran, A. Damaschun, A. Elstner, Kelly P. Smith, Gary S. Stein, and Anna Viega (In vitro cellular and developmental biology. Animal)

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Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors, Jonathan A. R. Gordon, Mohammad Q. Hassan, Sharanjot Saini, Martin A. Montecino, Andre J. Van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. Lian (Molecular and cellular biology)

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The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta, Min-Su Han, Hyo-Jin Kim, Hee-Jun Wee, Kyung-Eun Lim, Na-Rae Park, Suk-Chul Bae, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, and Je-Yong Choi (Journal of cellular biochemistry)

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A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program, Mohammad Q. Hassan, Jonathan A. R. Gordon, Marcio M. Beloti, Carlo M. Croce, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Proceedings of the National Academy of Sciences of the United States of America)

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Ribonucleoprotein immunoprecipitation (RNP-IP): a direct in vivo analysis of microRNA-targets, Mohammad Q. Hassan, Jonathan A. R. Gordon, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Journal of cellular biochemistry)

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The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues, Jae-Hwan Jeong, Youn-Kwan Jung, Hyo-Jin Kim, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Shin-Yoon Kim, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, and Je-Yong Choi (Molecular and cellular biology)

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A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes, Marci D. Jones, Julie C. Liu, Thomas K. Barthel, Sadiq Hussain, Erik Lovria, Dengfeng Cheng, Jesse A. Schoonmaker, Sudhanshu Mulay, David C. Ayers, Mary L. Bouxsein, Gary S. Stein, Siddhartha Mukherjee, and Jane B. Lian (Clinical cancer research : an official journal of the American Association for Cancer Research)

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Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer, Byoung H. Kang, Markus D. Siegelin, Janet Plescia, Christopher M. Raskett, David S. Garlick, Takehiko Dohi, Jane B. Lian, Gary S. Stein, Lucia R. Languino, and Dario C. Altieri (Clinical cancer research : an official journal of the American Association for Cancer Research)

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Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression, Kyle C. Kurek, Sara Del Mare, Zaidoun Salah, Suhaib Abdeen, Hussain Sadiq, Suk Hee Lee, Eugenio Gaudio, Nicola Zanesi, Kevin B. Jones, Barry DeYoung, Gail Amir, Mark Gebhardt, Matthew Warman, Gary S. Stein, Janet L. Stein, Jane B. Lian, and Rami I. Aqeilan (Cancer research)

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Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility, David T. Leong, Jitesh Pratap, Barry P. Pereira, Saminathan S. Nathan, Jason R. Dobson, Jane B. Lian, Yoshiaki Ito, Gary S. Stein, Manuel Salto-Tellez, Simon M. Cool, Andre J. Van Wijnen, Joleen Lim, Xuewei Goh, Hui S. Kwok, and P. Mathijs Voorhoeve (Breast cancer research : BCR)

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Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway, Ling Ling, Christian Dombrowski, Kin Mun Foong, Larisa M. Haupt, Gary S. Stein, Victor Nurcombe, Andre J. Van Wijnen, and Simon M. Cool (The Journal of biological chemistry)

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Glycosaminoglycans modulate RANKL-induced osteoclastogenesis, Ling Ling, Sadasivam Murali, Gary S. Stein, Andre J. Van Wijnen, and Simon M. Cool (Journal of cellular biochemistry)

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The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss, Jitesh Pratap, Jacqueline Akech, John J. Wixted, Gabriela Szabo, Sadiq Hussain, Meghan E. McGee-Lawrence, Xiaodong Li, Krystin Bedard, Robinder J. Dhillon, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jennifer J. Westendorf, and Jane B. Lian (Molecular cancer therapeutics)

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Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis, Meng Qiao, Yaqi Wang, Xiaoen Xu, Jing Lu, Yougli Dong, Wufan Tao, Janet L. Stein, Gary S. Stein, James D. Iglehart, Qian Shi, and Arthur B. Pardee (Molecular cell)

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Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer, Gary S. Stein, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, Martin A. Montecino, Carlo M. Croce, Je-Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan, Sayyed K. Zaidi, and Daniel W. Young (Advances in enzyme regulation)

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Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments, Gary S. Stein, Andre J. Van Wijnen, Jane B. Lian, Anthony N. Imbalzano, Martin A. Montecino, Sayyed K. Zaidi, Jane B. Lian, Jeffrey A. Nickerson, and Janet L. Stein (Critical reviews in eukaryotic gene expression)

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The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells, Margaretha Van der Deen, Jacqueline Akech, Tao Wang, Thomas J. Fitzgerald, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Journal of cellular biochemistry)

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Subnuclear localization and intranuclear trafficking of transcription factors, Sayyed K. Zaidi, Ricardo F. Medina, Shirwin M. Pockwinse, Rachit Bakshi, Krishna P. Kota, Syed A. Ali, Daniel W. Young, Jeffrey A. Nickerson, Amjad Javed, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information, Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Molecular and cellular biology)

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Mitotic bookmarking of genes: a novel dimension to epigenetic control, Sayyed K. Zaidi, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Nature reviews. Genetics)

Submissions from 2009

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Prostate cancer regulatory networks, Dario C. Altieri, Lucia R. Languino, Jane B. Lian, Janet L. Stein, Irwin Leav, Andre J. Van Wijnen, Zhong Jiang, and Gary S. Stein (Journal of cellular biochemistry)

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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis, Rami I. Aqeilan, John P. Hagan, Alain de Bruin, Maysoon Rawahneh, Zaidoun Salah, Eugenio Gaudio, Hasan Siddiqui, Stefano Volinia, Hansjuerg Alder, Jane B. Lian, Gary S. Stein, and Carlo M. Croce (Endocrinology)

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Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination, Xin-Zi Chi, Jiyeon Kim, Yong-Hee Lee, Jung-Won Lee, Kyeong-Sook Lee, Hee-Jun Wee, Wun-Jae Kim, Woo-Yoon Park, Byung-Chul Oh, Gary S. Stein, Yoshiaki Ito, Andre J. Van Wijnen, and Suk-Chul Bae (Cancer research)

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SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2, Fernando Cruzat, Berta Henriquez, Alejandro Villagra, Matias Hepp, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Gary S. Stein, and Martin A. Montecino (Biochemistry)

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Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer, Kakoli Das, David Tai Leong, Anurag Gupta, Liang Shen, Thomas Putti, Gary S. Stein, Andre J. Van Wijnen, and Manuel Salto-Tellez (European journal of cancer (Oxford, England : 1990))

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Survival responses of human embryonic stem cells to DNA damage, Tera M. Filion, Meng Qiao, Prachi N. Ghule, Matthew Mandeville, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Dario C. Altieri, and Gary S. Stein (Journal of cellular physiology)

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Secreted frizzled related protein 1 is a target to improve fracture healing, Tripti Gaur, John J. Wixted, Sadiq Hussain, Shannon L. O'Connell, Elise F. Morgan, David C. Ayers, Barry S. Komm, Peter V. N. Bodine, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types, Prachi N. Ghule, Zbigniew Dominski, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis, Larisa M. Haupt, Sadasivam Murali, Foong Kin Mun, Nadiya M. Teplyuk, Leong Fong Mei, Gary S. Stein, Andre J. Van Wijnen, Victor Nurcombe, and Simon M. Cool (Journal of cellular physiology)

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Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice, Ya-Huei Kuo, Sayyed K. Zaidi, Svetlana Gornostaeva, Toshihisa Komori, Gary S. Stein, and Lucio H. Castilla (Blood)

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Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation, Zhaoyong Li, Mohammad Q. Hassan, Mohammed Jafferji, Rami I. Aqeilan, Ramiro Garzon, Carlo M. Croce, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P, Partha Mitra, Prachi N. Ghule, Margaretha Van der Deen, Ricardo F. Medina, Ronglin Xie, William F. Holmes, Xin Ye, Keiichi I. Nakayama, J. Wade Harper, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Journal of cellular physiology)

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Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1), Barry P. Pereira, Ye-fang Zhou, Anurag Gupta, David T. Leong, Khin Zarchi Zarchi Aung, Ling Ling, Robert W. H. Pho, Mario Galindo, Manuel Salto-Tellez, Gary S. Stein, Simon M. Cool, Andre J. Van Wijnen, and Saminathan S. Nathan (Journal of cellular physiology)

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Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression, Jitesh Pratap, Karen M. Imbalzano, Jean. M. Underwood, Nathalie Cohet, Karthiga Devi Gokul, Jacqueline Akech, Andre J. Van Wijnen, Janet L. Stein, Anthony N. Imbalzano, Jeffrey A. Nickerson, Jane B. Lian, and Gary S. Stein (Cancer research)

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Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells, Inga A. San Martin, Nelson Varela, Marcia Gaete, Karina Villegas, Mariana Osorio, Julio Tapia, Marcelo Antonelli, Edna E. Mancilla, Barry P. Pereira, Saminathan S. Nathan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. Van Wijnen, and Mario Galindo (Journal of cellular physiology)

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Pluripotency: toward a gold standard for human ES and iPS cells, Kelly P. Smith, Mai X. Luong, and Gary S. Stein (Journal of cellular physiology)

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Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications, Jie Song, Jianwen Xu, Tera M. Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi (Journal of biomedical materials research. Part A)

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Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan (Annals of the New York Academy of Sciences)

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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan (Biochemistry and cell biology = Biochimie et biologie cellulaire)

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Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation, Marcela Stuardo, Milka Martinez, Karla Hildago, Martin A. Montecino, Amjad Javed, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Soraya E. Gutierrez (Journal of cellular physiology)

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The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts, Nadiya M. Teplyuk, Larisa M. Haupt, Ling Ling, Christian Dombrowski, Foong Kin Mun, Saminathan S. Nathan, Jane B. Lian, Janet L. Stein, Gary S. Stein, Simon M. Cool, and Andre J. Van Wijnen (Journal of cellular biochemistry)

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The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts, Nadiya M. Teplyuk, Ying Zhang, Yang Lou, John R. Hawse, Mohammad Q. Hassan, Viktor Teplyuk, Jitesh Pratap, Mario Galindo, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Andre J. Van Wijnen (Molecular endocrinology (Baltimore, Md.))

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Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor, John J. Wixted, Paul J. Fanning, Tripti Gaur, Shannon L. O'Connell, Jason Silva, April Mason-Savas, David C. Ayers, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles, Ronglin Xie, Ricardo F. Medina, Ying Zhang, Sadiq Hussain, Jennifer Colby, Prachi N. Ghule, Sakthi Sundararajan, Marilyn L. Keeler, Lijun Liu, Margaretha Van der Deen, Partha Mitra, Jane B. Lian, Jaime A. Rivera-PĂ©rez, Stephen N. Jones, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network, Sayyed K. Zaidi, Christopher R. Dowdy, Andre J. Van Wijnen, Jane B. Lian, Azra Raza, Janet L. Stein, Carlo M. Croce, and Gary S. Stein (Cancer research)

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The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells, Ying Zhang, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular biochemistry)

Submissions from 2008

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Phenotypic transcription factors epigenetically mediate cell growth control, Syed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, A. Rauf Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism, Rami I. Aqeilan, Mohammad Q. Hassan, Alain de Bruin, John P. Hagan, Stefano Volinia, Titziana Palumbo, Sadiq Hussain, Suk Hee Lee, Tripti Gaur, Gary S. Stein, Jane B. Lian, and Carlo M. Croce (The Journal of biological chemistry)

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The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes, Rachit Bakshi, Sayyed K. Zaidi, Sandhya Pande, Mohammad Q. Hassan, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Journal of cell science)

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Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells, Kerri L. George, Laura H. Saltman, Gary S. Stein, Jane B. Lian, and Robert B. Zurier (Journal of cellular physiology)

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Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells, Prachi N. Ghule, Zbigniew Dominski, Xiao-Cui Yang, William F. Marzluff, Klaus A. Becker, J. Wade Harper, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis, Mohammad Q. Hassan, Sharanjot Saini, Jonathan A. R. Gordon, Andre J. Van Wijnen, Martin A. Montecino, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Cells, tissues, organs)

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Specific residues of RUNX2 are obligatory for formation of BMP2-Induced RUNX2-SMAD complex to promote osteoblast differentiation, Amjad Javed, Faiza Afzal, Jong-Sup Bae, Soraya E. Gutierrez, Kaleem Zaidi, Jitesh Pratap, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Cells, tissues, organs)

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Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal, Amjad Javed, Jong-Sup Bae, Faiza Afzal, Soraya E. Gutierrez, Jitesh Pratap, Sayyed K. Zaidi, Yang Lou, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain, Jae-Hwan Jeong, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Julie C. Liu, Christopher J. Lengner, Florian Otto, Stefan Mundlos, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, and Je-Yong Choi (Journal of cellular physiology)