This collection showcases journal articles and other publications authored by researchers in the Cancer, Stem Cell and Bone Biology Program, headed by principal investigators Gary S. Stein, Janet L. Stein, Jane B. Lian, and Andre J. van Wijnen, in the Department of Cell and Developmental Biology at the University of Massachusetts Medical School.

Submissions from 2008

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A microRNA signature for a BMP2-induced osteoblast lineage commitment program, Zhaoyong Li, Mohammad Q. Hassan, Stefano Volinia, Andre J. Van Wijnen, Janet L. Stein, Carlo M. Croce, Jane B. Lian, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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A Runx2 threshold for the cleidocranial dysplasia phenotype, Yang Lou, Amjad Javed, Sadiq Hussain, Jennifer Colby, Dana Frederick, Jitesh Pratap, Ronglin Xie, Tripti Gaur, Andre J. Van Wijnen, Stephen N. Jones, Gary S. Stein, Jane B. Lian, and Janet L. Stein (Human molecular genetics)

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Human embryonic stem cell registries: value, challenges and opportunities, Mai X. Luong, Kelly P. Smith, and Gary S. Stein (Journal of cellular biochemistry)

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The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif, Ricardo F. Medina, Timothy F. Buck, Sayyed K. Zaidi, Angela Miele, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Biochemistry)

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MicroRNAs 221 and 222 bypass quiescence and compromise cell survival, Ricardo F. Medina, Sayyed K. Zaidi, Chang-Gong Liu, Janet L. Stein, Andre J. Van Wijnen, Carlo M. Croce, and Gary S. Stein (Cancer research)

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Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery, Martin A. Montecino, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Loreto Carvallo, Sylvain Marcellini, Fernando Cruzat, and Gloria Arriagada (Critical reviews in eukaryotic gene expression)

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Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma, Saminathan S. Nathan, Barry P. Pereira, Ye-fang Zhou, Anurag Gupta, Christian Dombrowski, Ritchie Soong, Robert W. H. Pho, Gary S. Stein, Manuel Salto-Tellez, Simon M. Cool, and Andre J. Van Wijnen (Molecular biology reports)

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Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes, Sandhya Pande, Syed A. Ali, Christopher R. Dowdy, Sayyed K. Zaidi, Kosei Ito, Yoshiaki Ito, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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In situ nuclear organization of regulatory machinery, Shirwin M. Pockwinse, Sayyed K. Zaidi, Ricardo F. Medina, Rachit Bakshi, Krishna P. Kota, Syed A. Ali, Daniel W. Young, Jeffrey A. Nickerson, Amjad Javed, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells, Jitesh Pratap, John J. Wixted, Tripti Gaur, Sayyed K. Zaidi, Jason Dobson, Karthiga Devi Gokul, Sadiq Hussain, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Cancer research)

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Gene expression in nuclear microenvironments for biological control and cancer, Gary S. Stein (Cancer biology and therapy)

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Nuclear microenvironments and cancer, Gary S. Stein, James R. Davie, J. Randy Knowlton, and Sayyed K. Zaidi (Journal of cellular biochemistry)

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Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan (Journal of cellular biochemistry)

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Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors, Nadiya M. Teplyuk, Mario Galindo, Viktor Teplyuk, Jitesh Pratap, Daniel W. Young, David S. Lapointe, Amjad Javed, Janet L. Stein, Jane B. Lian, Gary S. Stein, and Andre J. Van Wijnen (The Journal of biological chemistry)

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Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development, Brune Trevant, Tripti Gaur, Sadiq Hussain, John Symons, Barry S. Komm, Peter V. N. Bodine, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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Chromatin immunoprecipitation assays: application of ChIP-on-chip for defining dynamic transcriptional mechanisms in bone cells, Margaretha Van der Deen, Mohammad Q. Hassan, Jitesh Pratap, Nadiya M. Teplyuk, Daniel W. Young, Amjad Javed, Sayyed K. Zaidi, Jane B. Lian, Martin A. Montecino, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Methods in molecular biology (Clifton, N.J.))

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Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation, Ying Zhang, Mohammad Q. Hassan, Zhaoyong Li, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular biochemistry)

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Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats), Ying Zhang, Mohammad Q. Hassan, Ronglin Xie, John R. Hawse, Thomas C. Spelsberg, Martin A. Montecino, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (The Journal of biological chemistry)

Submissions from 2007

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Targeted deletion of Wwox reveals a tumor suppressor function, Rami I. Aqeilan, Francesco Trapasso, Sadiq Hussain, Stefan Costinean, Dean Marshall, Yuri Pekarsky, John P. Hagan, Nicola Zanesi, Mohamed Kaou, Gary S. Stein, Jane B. Lian, and Carlo M. Croce (Proceedings of the National Academy of Sciences of the United States of America)

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Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators, Gloria Arriagada, Roberto Paredes, Juan Olate, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein, Sergio Onate, and Martin A. Montecino (The Journal of steroid biochemistry and molecular biology)

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The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene, Loreto Carvallo, Berta Henriquez, Juan Olate, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Sergio Onate, Janet L. Stein, and Martin A. Montecino (The Journal of steroid biochemistry and molecular biology)

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1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex, Loreto Carvallo, Berta Henriquez, Roberto Paredes, Juan Olate, Sergio Onate, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Martin A. Montecino (Journal of cellular physiology)

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Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts, Mario Galindo, Rachel A. Kahler, Nadiya M. Teplyuk, Janet L. Stein, Jane B. Lian, Gary S. Stein, Jennifer J. Westendorf, and Andre J. Van Wijnen (Journal of molecular histology)

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Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells, Prachi N. Ghule, Klaus A. Becker, J. Wade Harper, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter, Jose L. Gutierrez, Roberto Paredes, Fernando Cruzat, David A. Hill, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein, Anthony N. Imbalzano, and Martin A. Montecino (The Journal of biological chemistry)

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HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes, Mohammad Q. Hassan, Rahul S. Tare, Suk Hee Lee, Matthew Mandeville, Brian Weiner, Martin A. Montecino, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Molecular and cellular biology)

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HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes, Mohammad Q. Hassan, Rahul S. Tare, Suk Hee Lee, Matthew Mandeville, Brian Weiner, Martin A. Montecino, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Molecular and cellular biology)

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p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation, Eric D. Jensen, Lingling Niu, Giuseppina Caretti, Samantha M. Nicol, Nadiya M. Teplyuk, Gary S. Stein, Vittorio Sartorelli, Andre J. Van Wijnen, Frances V. Fuller-Pace, and Jennifer J. Westendorf (Journal of cellular biochemistry)

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The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes, Ricardo F. Medina, Margaretha Van der Deen, Angela Miele, Ronglin Xie, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Cancer research)

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The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing, Angela Miele, Ricardo F. Medina, Andre J. Van Wijnen, Gary S. Stein, and Janet L. Stein (Journal of cellular biochemistry)

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An architectural perspective of vitamin D responsiveness, Martin A. Montecino, Gary S. Stein, Fernando Cruzat, Sylvain Marcellini, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gloria Arriagada (Archives of biochemistry and biophysics)

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Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence, Martin A. Montecino, Janet L. Stein, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Fernando Cruzat, Soraya E. Gutierrez, Juan Olate, Sylvain Marcellini, and Jose L. Gutierrez (Biochemistry and cell biology = Biochimie et biologie cellulaire)

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Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Amjad Javed, Martin A. Montecino, Je-Yong Choi, Diana Vradii, Sayyed K. Zaidi, Jitesh Pratap, and Daniel W. Young (Advances in enzyme regulation)

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Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition, Ronglin Xie, Lijun Liu, Partha Mitra, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Gene)

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Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130, Nancy Yeh, Jeffrey P. Miller, Tripti Gaur, Terence D. Capellini, Janko Nikolich-Zugich, Carmen de la Hoz, Licia Selleri, Timothy G. Bromage, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, Anxo Vidal, and Andrew Koff (Molecular and cellular biology)

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Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2, Daniel W. Young, Mohammad Q. Hassan, Jitesh Pratap, Mario Galindo, Sayyed K. Zaidi, Suk Hee Lee, Xiaoqing Yang, Ronglin Xie, Amjad Javed, Jean M. Underwood, Paul S. Furcinitti, Anthony N. Imbalzano, Sheldon Penman, Jeffrey A. Nickerson, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Nature)

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Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2, Daniel W. Young, Mohammad Q. Hassan, Xiaoqing Yang, Mario Galindo, Amjad Javed, Sayyed K. Zaidi, Paul S. Furcinitti, David S. Lapointe, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential, Sayyed K. Zaidi, Sandhya Pande, Jitesh Pratap, Tripti Gaur, Simina R. Grigoriu, Syed A. Ali, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Nuclear microenvironments in biological control and cancer, Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Nature reviews. Cancer)

Submissions from 2006

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Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation, Jong-Sup Bae, Soraya E. Gutierrez, Radhika Narla, Jitesh Pratap, Rajitha Devados, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Amjad Javed (Journal of cellular biochemistry)

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Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase, Klaus A. Becker, Prachi N. Ghule, Jaclyn A. Therrien, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells, Klaus A. Becker, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular physiology)

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The classic receptor for 1alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1alpha,25-dihydroxy vitamin D3 in osteosarcoma cells, Soraya Bravo, Roberto Paredes, Pamela Izaurieta, Jane B. Lian, Janet L. Stein, Gary S. Stein, Maria Victoria Hinrichs, Juan Olate, Luis G. Aguayo, and Martin A. Montecino (Journal of cellular biochemistry)

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Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation, Tripti Gaur, Lillian Rich, Christopher J. Lengner, Sadiq Hussain, Brune Trevant, David C. Ayers, Janet L. Stein, Peter V. N. Bodine, Barry S. Komm, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network, Mohammad Q. Hassan, Rahul S. Tare, Suk Hee Lee, Matthew Mandeville, Maria I. Morasso, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2, Rebecca A. Jackson, Sadasivam Murali, Andre J. Van Wijnen, Gary S. Stein, Victor Nurcombe, and Simon M. Cool (Journal of cellular physiology)

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Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling, Christopher J. Lengner, Heather Anne Steinman, James Gagnon, Thomas W. Smith, Janet E. Henderson, Barbara E. Kream, Gary S. Stein, Jane B. Lian, and Stephen N. Jones (The Journal of cell biology)

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Networks and hubs for the transcriptional control of osteoblastogenesis, Jane B. Lian, Gary S. Stein, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Martin Montecino, Mohammad Q. Hassan, Tripti Gaur, Christopher J. Lengner, and Daniel W. Young (Reviews in endocrine and metabolic disorders)

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Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells, Ling Ling, Sadasivam Murali, Christian Dombrowski, Larisa M. Haupt, Gary S. Stein, Andre J. Van Wijnen, Victor Nurcombe, and Simon M. Cool (Journal of cellular physiology)

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The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT, Ricardo F. Medina, Andre J. Van Wijnen, Gary S. Stein, and Janet L. Stein (Biochemistry)

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HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription, Partha Mitra, Ronglin Xie, J. Wade Harper, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (Journal of cellular biochemistry)

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Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone, Jitesh Pratap, Jane B. Lian, Amjad Javed, George L. Barnes, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Cancer metastasis reviews)

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Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells, Arun Rajgopal, Daniel W. Young, Khwaja A. Mujeeb, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein (Journal of cellular biochemistry)

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An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition, Gary S. Stein, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Martin A. Montecino, Sayyed K. Zaidi, and Corey D. Braastad (Journal of cellular physiology)

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Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity, Alejandro Villagra, Fernando Cruzat, Loreto Carvallo, Roberto Paredes, Juan Olate, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, Janet L. Stein, Anthony N. Imbalzano, and Martin A. Montecino (The Journal of biological chemistry)

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Alterations in intranuclear localization of Runx2 affect biological activity, Sayyed K. Zaidi, Amjad Javed, Jitesh Pratap, Tania M. Schroeder, Jennifer J. Westendorf, Jane B. Lian, Andre J. Van Wijnen, Gary S. Stein, and Janet L. Stein (Journal of cellular physiology)

Submissions from 2005

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The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis, Peter V. N. Bodine, Julia Billiard, Robert A. Moran, Helga Ponce-de-Leon, Sean McLarney, Annamarie Mangine, Melissa J. Scrimo, Ramesh A. Bhat, Barbara Stauffer, Jack Green, Gary S. Stein, Jane B. Lian, and Barry S. Komm (Journal of cellular biochemistry)

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The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts, Mario Galindo, Jitesh Pratap, Daniel W. Young, Hayk Hovhannisyan, Hee-Jeong Im, Je-Yong Choi, Jane B. Lian, Janet L. Stein, Gary S. Stein, and Andre J. Van Wijnen (The Journal of biological chemistry)

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Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression, Tripti Gaur, Christopher J. Lengner, Hayk Hovhannisyan, Ramesh A. Bhat, Peter V. N. Bodine, Barry S. Komm, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells, William F. Holmes, Corey D. Braastad, Partha Mitra, Cornelia Hampe, Detlef Doenecke, Werner Albig, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein (The Journal of biological chemistry)

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Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo, Amjad Javed, George L. Barnes, Jitesh Pratap, Tomasz Antkowiak, Louis C. Gerstenfeld, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype, Hyo-Jin Kim, Soon-Hyeun Nam, Hyun-Jung Kim, Hyo-Sang Park, Hyun-Mo Ryoo, Shin-Yoon Kim, Tae-Joon Cho, Seung-Gon Kim, Suk-Chul Bae, In-San Kim, Janet L. Stein, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, and Je-Yong Choi (Journal of cellular physiology)

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The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells, Yeon-Ju Kim, Hyun-Nam Kim, Eui-Kyun Park, Byung-Heon Lee, Hyun-Mo Ryoo, Shin-Yoon Kim, In-San Kim, Janet L. Stein, Jane B. Lian, Gary S. Stein, Andre J. Van Wijnen, and Je-Yong Choi (Gene)

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Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation, Christopher J. Lengner, Mohammad Q. Hassan, Ryan W. Serra, Christoph Lepper, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein (The Journal of biological chemistry)

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Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1, Xiangen Li, Diana Vradii, Soraya E.u Gutierrez, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Amjad Javed (Journal of cellular biochemistry)

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HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition, Angela Miele, Corey D. Braastad, William F. Holmes, Partha Mitra, Ricardo F. Medina, Ronglin Xie, Sayyed K. Zaidi, Xin Ye, Yue Wei, J. Wade Harper, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Molecular and cellular biology)

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Microtubule-dependent nuclear-cytoplasmic shuttling of Runx2, Shirwin M. Pockwinse, Arun Rajgopal, Daniel W. Young, Khwaja A. Mujeeb, Jeffrey A. Nickerson, Amjad Javed, Sambra D. Redick, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Stephen J. Doxsey (Journal of cellular physiology)

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The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion, Jitesh Pratap, Amjad Javed, Lucia R. Languino, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Molecular and cellular biology)

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Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1, Laura H. Saltman, Amjad Javed, John Ribadeneyra, Sadiq Hussain, Daniel W. Young, Philip Osdoby, Alla Amcheslavsky, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Zvi Bar-Shavit (Journal of cellular physiology)

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Mechanogenomic control of DNA exposure and sequestration, Gary S. Stein (The American journal of pathology)

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Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer, Gary S. Stein, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, Amjad Javed, Martin A. Montecino, Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, and Jitesh Pratap (Advances in enzyme regulation)

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Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes, Diana Vradii, Stefan Wagner, Diem N. Doan, Jeffrey A. Nickerson, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, Anthony N. Imbalzano, and Gary S. Stein (Journal of cellular physiology)

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Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype, Diana Vradii, Sayyed K. Zaidi, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Proceedings of the National Academy of Sciences of the United States of America)

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The dynamic organization of gene-regulatory machinery in nuclear microenvironments, Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, Jitesh Pratap, Amjad Javed, Martin A. Montecino, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, and Gary S. Stein (EMBO reports)

Submissions from 2004

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Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription, Faiza Afzal, Jitesh Pratap, Kosei Ito, Yoshiaki Ito, Janet L. Stein, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, and Amjad Javed (Journal of cellular physiology)

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Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease, George L. Barnes, Kerri E. Hebert, Mohammad H. Kamal, Amjad Javed, Thomas A. Einhorn, Jane B. Lian, Gary S. Stein, and Louis C. Gerstenfeld (Cancer research)

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice, Peter V. N. Bodine, Weiguang Zhao, Yogendra P. Kharode, Frederick J. Bex, Andre-Jean Lambert, Mary Beth Goad, Tripti Gaur, Gary S. Stein, Jane B. Lian, and Barry S. Komm (Molecular endocrinology (Baltimore, Md.))

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Functional characterization of a human histone gene cluster duplication, Corey D. Braastad, Hayk Hovhannisyan, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Gene)

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The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain, Soraya E. Gutierrez, Jilin Liu, Amjad Javed, Martin A. Montecino, Gary S. Stein, Jane B. Lian, and Janet L. Stein (The Journal of biological chemistry)

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Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene, Mohammad Q. Hassan, Amjad Javed, Maria I. Morasso, Jeremy Karlin, Martin A. Montecino, Andre J. Van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. Lian (Molecular and cellular biology)

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Immunofluorescence analysis using epitope-tagged proteins: in vitro system, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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In situ immunofluorescence analysis: analyzing RNA synthesis by 5-bromouridine-5'-triphosphate labeling, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Protein-deoxyribonucleic acid interactions linked to gene expression: electrophoretic mobility shift assay, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin A. Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Analysis of in vivo gene expression using epitope-tagged proteins, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Chromatin immunoprecipitation, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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In situ immunofluorescence analysis: immunofluorescence microscopy, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Protein-deoxyribonucleic acid interactions linked to gene expression: DNase I digestion, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Protein-deoxyribonucleic acid interactions linked to gene expression: ligation-mediated polymerase chain reaction, Amjad Javed, Sayyed K. Zaidi, Soraya E. Gutierrez, Christopher J. Lengner, Kimberly Stacy Harrington, Hayk Hovhannisyan, Brian C. Cho, Jitesh Pratap, Shirwin M. Pockwinse, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein (Methods in molecular biology (Clifton, N.J.))

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Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation, Christopher J. Lengner, Christoph Lepper, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian (Journal of cellular physiology)

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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors, Jane B. Lian, Amjad Javed, Sayyed K. Zaidi, Christopher J. Lengner, Martin Montecino, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein (Critical reviews in eukaryotic gene expression)

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Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells, Roberto Paredes, Gloria Arriagada, Fernando Cruzat, Alejandro Villagra, Juan Olate, Kaleem Zaidi, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Martin A. Montecino (Molecular and cellular biology)

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Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development, Nathan Smith, Yufeng Dong, Jane B. Lian, Jitesh Pratap, Paul D. Kingsley, Andre J. Van Wijnen, Janet L. Stein, Edward M. Schwarz, Regis J. O'Keefe, Gary S. Stein, and Hicham Drissi (Journal of cellular physiology)

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Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Amjad Javed, Martin A. Montecino, Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, Soraya E. Gutierrez, and Shirwin M. Pockwinse (Journal of cellular biochemistry)

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Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Martin A. Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, and Shirwin M. Pockwinse (Oncogene)

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Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals, Gary S. Stein, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Amjad Javed, Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, and Shirwin M. Pockwinse (European journal of histochemistry : EJH)

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Nomenclature for Runt-related (RUNX) proteins, Andre J. Van Wijnen, Gary S. Stein, J. Peter Gergen, Yoram Groner, Scott W. Hiebert, Yoshiaki Ito, Paul Liu, James C. Neil, Misao Ohki, and Nancy Speck (Oncogene)

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SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation, Daniel W. Young, Jitesh Pratap, Amjad Javed, Brian Weiner, Ohkawa Yasuyuki, Andre J. Van Wijnen, Martin A. Montecino, Gary S. Stein, Janet L. Stein, Anthony N. Imbalzano, and Jane B. Lian (Journal of cellular biochemistry)

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Quantitative signature for architectural organization of regulatory factors using intranuclear informatics, Daniel W. Young, Sayyed K. Zaidi, Paul S. Furcinitti, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein (Journal of cell science)

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The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse, Laurie A. Yunker, Anne Undersander, Jane B. Lian, Gary S. Stein, Cathy S. Carlson, and Laura J. Mauro (Journal of cellular biochemistry)

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription, Sayyed K. Zaidi, Andrew J. Sullivan, Ricardo F. Medina, Yoshiaki Ito, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein (The EMBO journal)