Title
TRAP-1, the mitochondrial Hsp90
UMMS Affiliation
Department of Cell Biology
Date
3-2012
Document Type
Article
Medical Subject Headings
HSP90 Heat-Shock Proteins
Disciplines
Cell Biology
Abstract
Protein folding quality control does not occur randomly in cells, but requires the action of specialized molecular chaperones compartmentalized in subcellular microenvironments and organelles. Fresh experimental evidence has now linked a mitochondrial-specific Heat Shock Protein-90 (Hsp90) homolog, Tumor Necrosis Factor Receptor-Associated Protein-1 (TRAP-1) to pleiotropic signaling circuitries of organelle integrity and cellular homeostasis. TRAP-1-directed compartmentalized protein folding is broadly exploited in cancer and neurodegenerative diseases, presenting new opportunities for therapeutic intervention in humans. This article is part of a Special Issue entitled: Heat Shock Protein 90 (Hsp90).
Rights and Permissions
Citation: Biochim Biophys Acta. 2012 Mar;1823(3):767-73. Epub 2011 Aug 22. Link to article on publisher's site