Title

Nonhistone chromosomal protein synthesis: utilization of preexisting and newly transcribed messenger RNA's

UMMS Affiliation

Department of Cell Biology

Date

7-6-1973

Document Type

Article

Medical Subject Headings

Chromatin; Chromosomes; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Female; Hela Cells; Humans; Mitosis; Nucleoproteins; RNA, Messenger; Templates, Genetic; Transcription, Genetic; Tritium; Tryptophan

Disciplines

Cell Biology

Abstract

Treatment of HeLa S(3) cells with actinomycin D during mitosis suppresses the synthesis of several major classes of nonhistone chromosomal proteins during the subsequent period before DNA replication, but allows the synthesis of other species of these proteins. Such results are consistent with the utilization of preexisting, as well as newly transcribed, messenger RNA's for nonhistone chromosomal protein synthesis during the prereplicative phase of the cell cycle.

Rights and Permissions

Citation: Science. 1973 Jul 6;181(94):71-3.

Related Resources

Link to Article in PubMed

PubMed ID

4714292